Radiopharmaceuticals for Positron Emission Tomography, Volume 1

by Scott, Peter J. H.; Hockley, Brian G.; Kilbourn, Michael R.

• ISBN13: 9780470588956
• ISBN10: 0470588950
• Edition: 1st
• Format: Hardcover
• Copyright: 2012-03-13
• Publisher: Wiley

Summary

This book is part of a series dedicated to providing reliable methods for radiochemical reactions, including all essential information to duplicate procedures. This first volume provides established, reliable synthetic methods for a large number of routinely-prepared positron emission tomography (PET) radiopharmaceuticals, commonly used in imaging for tumor studies, cardiology, and neuroscience. By giving researchers in the field necessary experimental details, the book eliminates the time-consuming process of searching journal articles and extracting pertinent details from lengthy experimental sections or supporting information.

Author Biography

Peter J. H. Scott is an Assistant Professor in the Department of Radiology at the University of Michigan Medical School. Dr. Scott edited Linker Strategies in Solid-phase Organic Synthesis (also from Wiley) and is the series editor for the Wiley Series on Solid Phase Organic Syntheses. Brian G. Hockley is Radiopharmaceutical Quality Manager at the University of Michigan Medical School, where he works with Michael Kilbourn on radiopharmaceutical research and development. Mr. Hockley has co-authored several articles and a chapter in Linker Strategies in Solid-phase Organic Synthesis (also from Wiley).

Table of Contents

Contributors	p. ix
Foreward	p. xvii
Preface	p. xix
Abbreviations	p. xxi
Fluorine-18 Labeled Radiopharmaceuticals	p. 1
Synthesis of [18-F]-Fluorodeoxyglucose ([18F]FDG)	p. 3
Synthesis of Sodium [18F]Fluoride (NA[18F]F)	p. 15
Radiosynthesis of 3'-Deoxy-3'-[18F]Fluorothymidine ([18F]FLT)	p. 21
Synthesis of [18F]Fluoroazomycin Arabinoside ([18F]FAZA)	p. 31
Synthesis of [18F]Fluoromisonidazole (1-(2-Hydroxy-3-[18F]Fluoropropyl)-2-Nitroimidazole, [18F]FMISO)	p. 41
Synthesis of [18F]FPPRGD2	p. 51
Synthesis of [18F]Fluorocholine ([18F]FCH)	p. 61
Clinical Manufacturing of [18F]-16-¿-Fluoroestradiol ([18F]FES)	p. 69
Synthesis of N-Succinimidyl 4-[18F]Fluorobenzoate ([18F]SFB	p. 81
Synthesis of 4-(2'-Methoxyphenyl)-1-[2'-(N-2"Pyridinyl)-p-[18F]Fluorobenzamido]Ethylpiperazine [18F]MPPF	p. 87
Synthesis of [18F]-Fallypride	p. 95
Synthesis of [18F]Fluoroethyltrosine (18F-FET)	p. 103
Synthesis of [18F]Flumazenil ([18F]FZ)	p. 111
Synthesis of 6-[18F]Fluorodopamine (6-[18F]FDA)	p. 125
Synthesis of 2-([18F]FLUORO)-3-[(2S)-2-Azetidinylmethoxy]Pyridine ([18F]2FA)	p. 139
Synthesis of [18F]-Substance-P Antagonist-Receptor Quantifier ([18F]SPA-RQ	p. 155
CARBON-11 Labeled Radiopharmaceuticals	p. 167
Synthesis of [11C]Choline Chloride ([11C]CHL)	p. 169
Synthesis of 2-(4-N-[11C]Methylaminophenyl)-6-Hydroxybenzothiazole ([11C]6-OH-BTA-1; [11C]PIB	p. 177
Synthesis of [11C]-Meta-Hydroxyephedrine ([11C]MHED)	p. 191
Synthesis of L-[Methyl-11C]Methionine ([11C]MET)	p. 199
Synthesis of (+)-¿-[11C]Dihydrotetrabenazine ([11C]DTBZ	p. 213
Synthesis of [11C]Flumazenil ([11C]FMZ)	p. 221
Synthesis of [11C]Hexadecanoic Acid ([11C]Palmitic Acid)	p. 233
Synthesis of O-Methyl-11C]Metomidate ([11C]-MTO)	p. 245
Synthesis of [11C]Carfentanil ([11C]CFN	p. 257
Synthesis of [Carbonyl-11C]Way-100635	p. 265
Synthesis of [11C]Raclopride	p. 275
Synthesis of 3-Amino-4-[2-(N-Methyl-N-[11C]Methyl-Amino-Methyl)Phenylsulfanyl]-Benzonitrile ([11C]DASB	p. 285
Synthesis of [11C]Acetate	p. 297
Synthesis of N-(2-[11C]Methoxybenzyl)-N-(4-Phenoxypyridin-3-YL)Acetamide ([sup>11C]PBR28)	p. 305
Other Radiopharmaceuticals	p. 313
Synthesis of [13N]Ammonia ([13N]NH3	p. 315
Synthesis of [68GA]Gallium Dota-(Tyr3)-Octreotide Acetate ([68GA]-Dotatoc)	p. 321
Supplier Information	p. 335
Index	p. 339
Table of Contents provided by Ingram. All Rights Reserved.