Reactive Intermediates MS Investigations in Solution

by Santos, Leonardo S.; Enke, Christie G.

• ISBN13: 9783527323517
• ISBN10: 3527323511
• Edition: 1st
• Format: Hardcover
• Copyright: 2010-02-01
• Publisher: Wiley-VCH

Summary

Edited by a top expert, this book represents a powerful tool showing how to successfully apply ESI-MS in revealing, elucidating and helping to consolidate several proposed mechanisms of organic reactions that need to be emphasized. With an introduction by Noble laureate John Fenn

Author Biography

After being awarded his MSc in 1999 Leonardo Silva Santos joined the Universidade Estadual de Campinas in Brasil for his thesis working on the total synthesis of natural products, while also doing research for two years at the University of Chicago in 2001-2002. After beind awarded his Ph.D. in 2003 he did postdoctoral research at UNICAMP, Brasil, and at the Carl von Ossietzky Universit+ñt Oldenburg. He is currently Professor at the Universidad de Talca, Chile.

Table of Contents

Foreword

Preface

List of Contributors

A Brief Overview of the Mechanisms Involved in Electrospray Mass Spectrometry

Introduction

Production of Gas-Phase Ions by Electrospray and Electrospray Ionization Mass Spectrometry

Historical Perspectives in the Study of Ion Chemistry by Mass Spectrometry From the Gas Phase to Solution

A Brief History and Recent Advances in Mass Spectrometry

Overview of the Study of Ion/Molecule Reactions in the Gas Phase by Mass Spectrometry

Future Perspectives

Organic Reaction Studies by ESI-MS

Introduction

Reaction Mechanisms

General Remarks

Studies of Reaction Mechanism Intermediates by ESI-MS

Introduction

Studies on the Intermediates and Mechanisms of Pd-Catalyzed Reactions

Studies on Some Reactive Intermediates and Mechanisms of Radical Reactions

Studies on the Intermediates and Mechanism of Organocatalysis Reactions

Studies on the Intermediates and Mechanism of Transition Metal-Catalyzed Polymerization Reactions

On-line Monitoring Reactions by Electrospray Ionization Mass Spectrometry

Introduction

Preservation of the Charge in the Transit of Ions from Solution to the Gas Phase Using the ESI Technique

Developing Methods to Study Reaction Mechanisms

Probing Reactivity of Intermediates

Conclusion

Gas Phase Ligand Fragmentation to Unmask Reactive Metallic Species

Introduction and Scope of the Review

Unmasking Reactive Metallic Intermediates via Collision-Induced Dissociation

Conclusions

Palladium Intermediates in Solution

Introduction

ESI-MS Studies in Suzuki-Miyaura Cross-Coupling and Related Reactions

ESI-MS Studies in the Identification of Oxidative Addition Intermediates

ESI-MS Studies in Mizoroki-Heck and Related Reactions

ESI-MS Studies in Stille Cross-Coupling Reactions

ESI-MS Studies in Palladium-Catalyzed Reactions Involving Allenes

ESI-MS Studies in Palladium-Catalyzed Alkynylation Reactions

ESI-MS Studies in Palladium-Catalyzed Allylic Substitution Reactions

ESI-MS Studies in Palladium-Catalyzed Oxidation of 2-Allylphenols

ESI-MS Studies in Palladium-Catalyzed Polymerization Reactions

Conclusions

Practical Investigation of Molecular and Biomolecular Noncovalent Recognition Processes in Solution by ESI-MS

Introduction

Methods and Applications

Practical Aspects of Titration Analysis

Summary and Outlook

References

Index

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