Redox Signaling and Regulation in Biology and Medicine

by Editor: Claus Jacob (Saarland University, Germany); Editor: Paul G. Winyard (Universities of Exeter and Plymouth, Great Britain)

• ISBN13: 9783527627592
• ISBN10: 3527627596
• Format: eBook
• Copyright: 2009-05-01
• Publisher: Wiley-VCH

Summary

This first entry-level guide to the multifaceted field takes readers one step further than existing textbooks. In an easily accessible manner, the authors integrate the biochemistry, cell biology and medical implications of intracellular redox processes, demonstrating that complex science can be presented in a clear and almost entertaining way. Perfect for students and junior researchers, this is an equally valuable addition to courses in biochemistry, molecular biology, cell biology, and human physiology.

Table of Contents

Introduction

Biological Systems Relevant for Redox Signaling and Control

Cellular Generation of Oxidants: Relation to Oxidative Stress

The Chemical Basis of Biological Redox Control

Protein Glutathiolation

Structure and Function of the Human Peroxiredoxin-Based Antioxidant System: the Interplay between Peroxiredoxins, Thioredoxins, Thioredoxin Reductases, Sulfiredoxins and Sestrins

Hydrogen Peroxide and Cysteine Protein Signaling Pathways

Protein Tyrosine Phosphatases as Mediators of Redox Signaling

Hypoxia-Induced Gene Regulation through Hypoxia Inducible Factor-1a

Eicosanoid-Based Signaling

Redox-Controlled Transcription Factors and Gene Expression

Nitric Oxide Regulation in Redox Signaling

Is Hydrogen Sulfide a Regulator of Nitric Oxide Bioavailability in the Vasculature?

Aspects of Nox/Duox Signaling

Photodynamic Therapy with Aminolevulinic Acid and Iron Chelators: A Clinical Example of Redox Signaling

Oxidative Stress and Apoptosis

Redox Regulation of Apoptosis in Immune Cells

Redox Control in Human Disease with a Special Emphasis on the Peroxiredoxin-Based Antioxidant System

Free Radicals and Mammalian Aging

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