Regulators of Ovarian Functions

by Sirotkin, Alexander V.

• ISBN13: 9781616680404
• ISBN10: 1616680407
• Edition: 1st
• Format: Hardcover
• Copyright: 2011-03-01
• Publisher: NOVA SCIENCE PUBLISHERS INC

Summary

This book represents an attempt to review the most recent knowledge concerning basic processes occurring in the most important female reproductive organ -- ovary and their regulators. The most important processes (ovarian cyclic changes and oogenesis), as well as their extracellular (hormones and growth factors) and intracellular (protein kinases, transcription factors, small RNAs) regulators are described. Data concerning processes or substances well described in previous reviews are summarised here in a short form with references to corresponding reviews.

Author Biography

The author of this book, Alexander Sirotkin, is one of the known world specialists in biology of reproduction and leaders in studies of some ovarian signaling substances (small RNAs, transcription factors, protein kinases, metabolic hormones a.o.). He received his RNDr. degree at the University of Leningrad (USSR), his PhD at the Institute of Evolutionary Physiology and Biochemistry (Leningrad, USSR) and his DrSc degree at the Research Institute of Animal Production (Nitra, Slovakia). He worked as research scientist, senior research scientist, head of the laboratory, and project leader at the Research Institute of Animal Breeding and Genetics (Leningrad-Pushkin, USSR), International Laboratory for Biotechnology (Nitra, Czechoslovakia), Research Institute of Animal Production/Animal Production Research Centre (Nitra, Slovakia) and Constantine the Philosopher University (Nitra, Slovakia). He had fellowships at the Institute of Physiology and Genetics (Libechov, Czechoslovakia), Institute of Experimental Endocrinology (Bratislava, Slovakia), Research Centre of Animal Production (Dummerstorf, Germany), Institute for Animal Science and Animal Behaviour (Celle, Germany), Institute of Animal Science (Mariensee, Germany), University of Colonia (Colonia, Germany), Babraham Institute (Babraham, UK), University of Bristol (Bristol, UK), University of Nottingham (Sutton Bonington, UK) and other international research centers. His teaching activities included lectures at more than 10 universities and research centers, as well as the supervision of more than 30 undergraduate and PhD student works. He has more than 400 publications, mainly in international biomedical journals. For the results obtained during his basic and applied studies and related publications in the area of biology of reproduction, he was nominated for a number of national and international awards.

Table of Contents

Preface	p. ix
Foreword	p. xiii
The Ovary and Ovarian Cycle	p. 1
The Ovary	p. 1
References	p. 11
Oocytes and their Maturation	p. 15
Oocyte	p. 15
Oocyte Nuclear Maturation	p. 16
Oocyte Cytoplasmic Maturation	p. 20
References	p. 22
Extracellular Regulators of Ovarian Functions	p. 25
Function and Classification of Biological Signaling Substances	p. 26
Hormones and Hormone-Like Substances	p. 27
Extracellular Regulators of Ovarian Functions	p. 31
References	p. 63
Protein Kinases in Control of Ovarian Functions	p. 75
Introduction	p. 75
Function and Classification of Protein Kinases	p. 76
Presence of Protein Kinases in the Ovary	p. 77
Protein Kinases Control Ovarian Cell Proliferation	p. 79
Protein Kinases Control Ovarian Cell Apoptosis	p. 82
Protein Kinases Control Maturation of Oocyte-Cumulus Complex	p. 82
Protein Kinases Control Release of Hormones by Ovarian Cells	p. 84
Protein Kinases Control Hormone Receptors and Response to Hormones	p. 86
Protein Kinases Mediate Effect of Hormones on the Ovary	p. 87
Interrelationships between Different Protein Kinases in the Ovary	p. 88
Protein Kinases can be used for Control of Fertility, Ovarian Cycle and Health	p. 90
References	p. 93
Transcription Factors in Control of Ovarian Functions	p. 101
Function and Classification of Transcription Factors	p. 101
Transcription Factors Involved in Control of Follicular Development and Selection	p. 103
Transcription Factors Involved in Control of Ovarian Cell Proliferation and Cancerogenesis	p. 105
Transcription Factors Involved in Control of Ovarian Cell Apoptosis	p. 107
Transcription Factors Involved in Control of Ovarian Secretory Activity	p. 107
Transcription Factors Involved in Oocyte/Cumulus Maturation	p. 112
Transcription Factors Involved In Control of Ovulation and Luteogenesis	p. 113
Transcription Factors Involved in Mediation Effect of Hormones	p. 114
Transcription Factors Involved in Mediation Effect of Growth Factors an Cytokines	p. 115
Conclusion	p. 116
References	p. 118
RNA Interference in Control of Ovarian Functions	p. 125
Function and Classification of Small RNAs	p. 126
Expression of Small RNAs in the Ovary	p. 128
RNA Interference and Ovarian Cell Proliferation	p. 129
RNA Interference and Ovarian Cell Apoptosis	p. 133
RNA Interference and Ovarian Secretory Activity	p. 135
RNA Interference and Ovarian Luteogenesis	p. 141
RNA Interference and Oocyte Maturation	p. 141
RNA Interference and Recombinant Protein Production	p. 142
Improvement of Small RNA Delivery	p. 143
References	p. 144
Regulation of Oocyte Maturation	p. 153
Extracellular Regulators of Oocyte Nuclear and Cytoplasmic Maturation	p. 153
Intracellular Regulators Of Oocyte Nuclear Maturation	p. 155
Intracellular Regulators of Oocyte Cytoplasmic Maturation	p. 158
Interrelationships between Regulators of Oocyte Maturation	p. 159
References	p. 160
Physiological and Artifical Regulation of Ovarian Cycle	p. 163
Physiological Regulation of Ovarian Cycle	p. 163
Artificial Regulation of the Ovarian Cycle	p. 175
References	p. 180
Index	p. 185
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