Reproductive Medicine : Molecular, Cellular and Genetic Fundamentals

by Fauser; Bart C.J.M.

• ISBN13: 9781842140192
• ISBN10: 1842140191
• Edition: 2nd
• Format: Hardcover
• Copyright: 2002-11-11
• Publisher: CRC Press

Summary

Focusing on the cutting edge of recent medical knowledge and advances, this new edition of Fauser's highly acclaimed advanced textbook fills a unique role. Reproductive Medicine: Molecular, Cellular, and Genetic Fundamentals explains and clarifies for non-specialist physicians the complex biochemistry and biology underlying the current practice of assisted reproduction - understanding which is now essential for all those hoping to practice successfully in this field.The first edition, Molecular Biology in Reproductive Medicine represented a ground-breaking initiative in presenting complicated science in a comprehensible and practical way and received accolades from many authoritative reviewers for its remarkable achievement. The new edition takes this initiative to a new level, completely re-writing the original edition, incorporating and interpreting the latest research findings of this extraordinarily fast-moving field, while keeping those features that made the first edition a bestseller. With a uniquely distinguished team of international contributors, Reproductive Medicine: Molecular, Cellular, and Genetic Fundamentals represents the current state of knowledge essential for the most effective application of assisted reproduction techniques.

Table of Contents

List of the Editors	ix
List of the Contributors	xi
Editors Introduction	xvii
Foreword	xix
SECTION I Molecular biology	1	(54)
Aaron J. W. Hsueh
Introduction to molecular biology	3	(18)
Margaret A. Shupnik
Functional genomics	21	(18)
Aaron J.W. Hsueh
Molecular genetics	39	(16)
Margaret A. Shupnik
SECTION II Cell biology	55	(142)
Jerome F. Strauss III
The cell cycle and differentiation in the reproductive system	57	(14)
Debra J. Wolgemuth
Apoptosis	71	(20)
Jonathan L. Tilly
Molecular carcinogenesis	91	(28)
Jeff Boyd
Angiogenesis and reproduction	119	(18)
Stephen Smith
Hormones and cancer	137	(16)
Sandra Timm Pearce
V. Craig Jordan
Immunogenetics: genetic regulation of immunity in pregnancy	153	(16)
Joan S. Hunt
Transgenic technology, cloning and germ cell transplantation	169	(28)
Kathleen H. Burns
Francesco J. DeMayo
Martin M. Matzuk
SECTION III Hormone synthesis, action and signal transduction	197	(116)
Philippe Bouchard
Gonadotropin-releasing hormones and their receptors	199	(26)
Robert P. Millar
Gonadotropins and gonadotropin receptors	225	(20)
Manuel Tena-Sempere
Ilpo T. Huhtaniemi
Steroidogenesis	245	(22)
Walter L. Miller
Synthia H. Mellon
Aromatase: glandular and extraglandular activity	267	(12)
Linda R. Nelson
Serdar E. Bulun
Steroid hormone receptors	279	(16)
Albert O. Brinkmann
Cytokines, growth factors and their receptors	295	(18)
Stacey C. Chapman
Teresa K. Woodruff
SECTION IV Molecular pharmacology	313	(50)
Anthony J. Rutherford
Gonadotropin-releasing hormone analogs	315	(20)
Nathalie Chabbert-Buffet
Bart C.J.M. Fauser
Philippe Bouchard
Gonadotropins and gonadotropin mimics	335	(18)
Albina Jablonka-Shariff
Wiebe Olijve
Irving Boime
Selective estrogen receptor modulators	353	(10)
Bin Chen
V. Craig Jordan
SECTION V Gamete and embryo biology	363	(132)
Andre Van Steirteghem
Female gametogenesis	365	(16)
Roger Gosden
Hugh Clarke
David Miller
Male gametogenesis	381	(20)
Willy M. Baarends
J. Anton Grootegoed
Fertilization	401	(20)
Laura Hewitson
Calvin Simerly
Gerald Schatten
Preimplantation embryo development	421	(18)
Keith E. Latham
Richard M. Schultz
Implantation and endometrial function	439	(28)
Linda C. Giudice
Concepts in early embryonic patterning	467	(28)
G. Praveen Raju
Change Tan
Peter S. Klein
SECTION VI Principles of medical genetics	495	(44)
Joe Leigh Simpson
Genetic counselling in reproductive disorders	497	(18)
Inge Liebaers
Joe Leigh Simpson
Preimplantation genetic diagnosis and screening	515	(8)
Karen Sermon
Inge Liebaers
Genetic analysis of complex (multifactorial) diseases	523	(16)
Stephen Kennedy
SECTION VII Reproductive dysfunction	539	(128)
Bart C.J.M. Fauser
Male pseudohermaphroditism, true hermaphroditism and XY sex reversal	541	(24)
Joe Leigh Simpson
Female pseudohermaphroditism and 21-hydroxylase deficiency	565	(10)
Maria I. New
Persistence of Mullerian derivatives in males	575	(12)
Nathalie Josso
Chrinne Belville
Jean-Yves Picard
Premature ovarian failure	587	(14)
Gerard S. Conway
Sophie Christin-Maitre
Polycystic ovary syndrome	601	(14)
Richard S. Legro
Jerome F. Strauss III
Genetics of male reproductive dysfunction	615	(16)
Willy Lissens
Endocrine disruptors and male reproductive function	631	(14)
Marianne Jorgensen
Niels E. Skakkebaek
Henrik Leffers
Ethics of assisted reproduction	645	(22)
Guido de Wert
Index	667