Research on the Neurobiology of Alcohol Use Disorders

by Sher, Leo

• ISBN13: 9781604561975
• ISBN10: 1604561971
• Edition: 1st
• Format: Hardcover
• Copyright: 2008-08-01
• Publisher: NOVA SCIENCE PUBLISHERS INC

Summary

This book describes the neurobiological mechanisms of alcohol abuse and dependence including the role of serotonergeic, dopaminergic, noradrenergic, and hypothalamic-piturary adrenal systems in alcohol use disorders and the results of neuroimaging studies are presented. The neurobiology of comorbidity of alcohol use disorders with other psychiatric disorders are also discussed. Research on the neurobiology of alcohol abuse and dependence is very important. Therefore, this book will be of interest to biomedical researchers, physicians, and other clinicians, students, and anyone who is interested in the mechanisms of addictive disorders.

Table of Contents

Neurobiology of alcohol use disorders : plenty of room for new research	p. 1
Epidemiology of alcohol use, abuse, and dependence	p. 5
Recognizing alcohol use disorders	p. 17
Biochemical measures of alcohol consumption	p. 33
Neurobiological correlates of the disposition and maintenance of alcoholism	p. 47
Is thiamine deficiency one cause of familial alcoholism?	p. 65
Pharmacogenetics and the future of alcohol dependence treatment	p. 79
Acamprosate : elucidating the mechanism of action and its protective effects	p. 113
Neurobiology of suicidal behavior in alcohol use disorders	p. 125
Effect of natural and synthetic polyamines on ethanol intake	p. 139
Glial and neuronal packing density in the orbitofrontal cortex in alcohol dependence	p. 159
Ethanol exposure and pro-enkephalin mRNA expression in regions of the mesocorticolimbic system	p. 177
Importance of alcohol induced modulation of nitric-oxide synthase in the brain	p. 203
Neural stem cells - a potential mechanism in alcoholic neurodegeneration and recovery	p. 219
Alcohol-induced blood-brain barrier dysfunction	p. 239
Hypothalamic-pituitary-adrenocortical axis activity and alcohol use disorders	p. 261
Cognitive deficits in individuals prenatally exposed to alcohol	p. 277
Genetic influences on alcohol use and dependence	p. 291
Women, alcohol drinking, environment : the role of biological markers	p. 321
List of contributors	p. 339
Index	p. 343
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