Retinal Degenerations

by Tombran-Tink, Joyce, Ph.D.; Barnstable, Colin J.

• ISBN13: 9781588296207
• ISBN10: 1588296202
• Edition: CD
• Format: Hardcover
• Copyright: 2007-11-03
• Publisher: Humana Pr Inc

Summary

In Retinal Degenerations: Biology, Diagnostics, and Therapeutics, editors Joyce Tombran-Tink and Colin Barnstable present new and noteworthy research into retinal diseases. Written by renowned scientific investigators, this innovative collection of treatment strategies and technological discoveries allows for the realistic translation of research into practice. Following an exciting preface describing the diagnosis and treatment of retinal degenerations from antiquity to the modern era, this four-part volume begins with thought-provoking portraits of the reality of life with retinal degenerations, as experienced by sufferers of the disease. In Part II, researchers and practitioners examine seven different retinal diseases, including: age-related macular degeneration, Leber Congenital Amaurosis, Macular Degeneration, Stargardt Disease, X-Linked Juvenile Retinoschisis, Usher Syndrome, and Retinitis Pigmentosa. Part III discusses our current understanding of the underlying mechanisms of retinal degeneration, and in Part IV, the challenges of therapeutic strategies for retinal degenerative diseases are emphasized as researchers discuss cutting-edge treatments. Retinal Degenerations: Biology, Diagnostics, and Therapeutics brings the scientific community to the frontline of research into diseases of the retina and challenges scientists in academia and the pharmaceutical industry to develop innovative strategies for the translation of investigative research into viable therapeutics.

Table of Contents

Preface	p. v
Contributors	p. xv
Companion CD	p. xix
Living With Retinal Degeneration
Coping With Retinal Degeneration: A Patient's View	p. 3
Degenerative Diseases of the Retina
Epidemiology of Age-Related Macular Degeneration Early in the 21st Century	p. 23
Leber Congenital Amaurosis: A Hereditary Childhood Form of Blindness and a Model to Elucidate Retinal Physiology and Development	p. 61
Macular Degeneration: Aging Changes and Novel Therapies	p. 91
Stargardt Disease: From Gene Discovery to Therapy	p. 105
X-Linked Juvenile Retinoschisis	p. 119
Retinal Degeneration in Usher Syndrome	p. 137
Mouse Models of Retinitis Pigmentosa	p. 149
Mechanisms Underlying Retinal Degenerations
The Impact of Diabetes on Neuronal, Glial, and Vascular Cells of the Retina: Implications for the Pathogenesis of Diabetic Retinopathy	p. 165
Statins and Age-Related Maculopathy	p. 185
The Role of Drusen in Macular Degeneration and New Methods of Quantification	p. 197
RPE Lipofuscin: Formation, Properites, and Relevance to Retinal Degeneration	p. 213
Genetic Modifiers That Affect Phenotypic Expression of Retinal Diseases	p. 237
X-Linked Retinal Dystrophies and Microtubular Functions Within the Retina	p. 257
Synaptic Remodeling in Retinal Degeneration	p. 269
Developing Theraputic Strategies for Retinal Degenerative Diseases
On the Suppression of Phtoreceptor Cell Death in Retinitis Pigmentosa	p. 293
Cell-Based Therapies to Restrict the Progress of Photoreceptor Degeneration	p. 319
Current Status of IPE Transplantation and its Potential as a Cell-Based Therapy for Age-Related Macular Degeneration and Retinal Dystrophies	p. 345
Recent Results in Retinal Transplantation Give Hope for Restoring Vision	p. 365
Stem Cells and Retinal Transplantation	p. 385
Application of Encapsulated Cell Technology for Retinal Degenerative Diseases	p. 401
Effective Treatment for the Canine RPE65 Null Mutation, a Hereditary Retinal Dystrophy Comparable to Human Leber's Congenital Amaurosis	p. 415
The Use of Neuroprotective Factors in Retinal Degenerations	p. 433
Carbonic Anhydrase Inhibitors as a Possible Therapy for RP17, an Autosomal Dominant Retinitis Pigmentosa Associated With the R14W Mutation, Apoptosis, and the Unfolded Protein Response	p. 455
Macular Degeneration-An Addendum	p. 459
Index	p. 463
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