Rheumatoid Arthritis Frontiers in Pathogenesis and Treatment

by Firestein, Gary S.; Panayi, Gabriel S.; Wollheim, Frank A.

• ISBN13: 9780192629722
• ISBN10: 0192629727
• Edition: 1st
• Format: Hardcover
• Copyright: 2000-08-17
• Publisher: Oxford University Press

Summary

This book presents the cutting edge of developments in etiology,mechanisms of inflammation, disease manifestations and management of thiscommon, crippling disease. Here is a new major volume on the subject of greatimportance in rheumatology - the first in-depth, multiauthor textbook on RA for15 years. Therapy for RA has traditionally been with non-steroidanti-inflammatory drugs, progressing to second-line drugs, but this has not beeneffective in preventing erosion of bone and symptoms. Rapid recent advances inknowledge have led to new concepts in the mechanisms of the disease and excitingnew possibilities for treatment. This book deals with the scientific basis ofthe pathogenesis of rheumatoid arthritis which then goes on to form the basis ofscientific discussion and the rationale for the treatment, both drug andnon-drug, of the disease. The book describes the latest advances in ourunderstanding of this common, crippling disease and relates this knowledge tothe application of a more rational therapeutic approach to its management Thebook covers all areas of importance to disease management including social andpsychological aspects, genetic susceptibility, biological/immunologicalresearch, classic and other treatments (eg. physiotherapy, occupational therapy,complementary therapy, diet and patient education), management of pain, healtheconomics and disease management strategies. This book is a 'must' for allrheumatologists and anyone working in the field.

Table of Contents

List of contributors	xi
SECTION 1 ETIOLOGY
Current perspectives on the genetics of rheumatoid arthritis	3	(12)
Mark Fife
Gerald Coakley
Jerry Lanchbury
Epidemiology of rheumatoid arthritis	15	(12)
Franz Calvo
Graciela S. Alarcon
Infection in the pathogenesis of rheumatoid arthritis	27	(12)
Gabrielle Kingsley
Experimental models for rheumatoid arthritis	39	(16)
Rikard Holmdahl
SECTION 2 MECHANISMS OF INFLAMMATION
Examination of the synovium and synovial fluid	55	(14)
Paul-Peter Tak
The role of macrophages in rheumatoid arthritis	69	(20)
Raimund W. Kinne
Bruno Stuhlmuller
Ernesta Palombo-Kinne
Gerd-R. Burmester
The role of T lymphocytes in rheumatoid arthritis	89	(12)
David A. Fox
The role of neutrophils in rheumatoid arthritis	101	(12)
W. Winn Chatham
Jeffrey C. Edberg
Robert P. Kimberly
The role of fibroblast-like synoviocytein rheumatoid arthritis	113	(24)
Percio S. Gulko
Tetsunori Seki
Robert Winchester
Adhesion, migration, and cell trafficking	137	(10)
Costantino Pitzalis
Cytokine networks	147	(18)
William R. Arend
Cem Gabay
Apoptosis in rheumatoid arthritis: cause or consequence	165	(14)
Nathan J. Zvaifler
Rheumatoid factor	179	(10)
Diego Kyburz
Dennis A. Carson
Mechanisms of joint destruction	189	(12)
Thomas Pap
Renate E. Gay
Steffen Gay
Pain mechanisms in rheumatoid arthritis	201	(12)
Bruce Kidd
Paul Mapp
David Blake
SECTION 3 CLINICAL ASPECTS
Rheumatoid arthritis: clinical picture and its variants	213	(14)
William F. Lems
Ben A.C. Dijkmans
Extra-articular features of rheumatoid arthritis	227	(16)
D. O'Gradaigh
R.A. Watts
D.G.I. Scott
The neuroendocrine axis in rheumatoid arthritis	243	(12)
Ronald L. Wilder
Ilia J. Elenkov
Imaging	255	(20)
Dolores Kalden-Nemeth
Bernhard Manger
Outcome and mortality	275	(16)
Marjatta Leirisalo-Repo
Molecular markers for assessment of cartilage damage in rheumatoid arthritis	291	(16)
Tore Saxne
Bengt Mansson
SECTION 4 DRUG THERAPY
NSAIDs and analgesics	307	(22)
Richard Day
David Quinn
Lynnette March
Garry Graham
Kenneth Williams
Systemic glucocorticoids in rheumatoid arthritis	329	(8)
Roger Hallgren
Methotrexate	337	(14)
Rolf Rau
Gold, antimalarials, sulfasalazine, and other DMARDs	351	(10)
Piet L.C.M. van Riel
Eric-Jan J.A. Kroot
Intra-articular therapy	361	(10)
Peter Lanyon
Michael Doherty
Combination therapy for rheumatoid arthritis	371	(12)
Philip G. Conaghan
Peter M. Brooks
SECTION 5 NON-DRUG THERAPY
The impact of physiotherapy	383	(10)
Ulrich Moritz
Occupational therapy and assistive technology	393	(10)
Ulla Nordenskiold
Diets	403	(12)
Lars Skoldstam
Psychological and social aspects	415	(12)
Tore Kristian Kvien
Liv Marit Smedstad
Patient education	427	(8)
Ylva Lindroth
Non-drug management of chronic pain	435	(8)
Wolfgang Hamann
Health economics	443	(10)
Leigh F. Callahan
SECTION 6 SURGICAL THERAPY
Large joints and feet	453	(14)
Urban Rydholm
The hand	467	(10)
Christer Sollerman
The cervical spine	477	(12)
A.T.H. Casey
H.A. Crockard
Medical synovectomy (synoviorthesis)	489	(10)
C.J. Menkes
S. Diallo
SECTION 7 FRONTIERS OF THERAPY
Anticytokine therapy: TNF inhibitors and other novel approaches	499	(14)
Tom W.J. Huizinga
Ferdinand C. Breedveld
The design of clinical trials	513	(14)
David L. Scott
Anti-T lymphocyte therapies	527	(12)
Ernest H.S. Choy
Antimacrophage therapies	539	(12)
Alison M. Badger
Inhibition of matrix metalloproteinases in rheumatoid arthritis	551	(12)
Tim Shaw
Small molecule inhibitors of signal transduction	563
Anthony M. Manning