Rickettsioses From Genome to Proteome, Pathobiology, and Rickettsiae as an International Threat, Volume 1063

by Oteo, Jose A.; Hechemy, Karim E.; Raoult, Didier A.; Silverman, David J.; Blanco, José; R.

• ISBN13: 9781573316019
• ISBN10: 1573316016
• Edition: 1st
• Format: Paperback
• Copyright: 2005-03-04
• Publisher: Wiley-Blackwell

Summary

Rickettsial diseases have affected humanity since the dawn of civilization. Despite the advent of effective antibiotic therapy, humans continue to be afflicted by rickettsial diseases, which still often go undiagnosed because of their protean clinical manifestations.During the past decade, several major developments have occurred in rickettsiology. With the advent of the newly emerging infections caused by a number of rickettsias, the re-emerging of old pathogenic species of rickettsias that cause both old and new syndromes has helped redefine the level of rickettsial pathogenicity. The intracellular nature of most rickettsias remains a mystery although their genome size is close to that of the free-living neisserias.Advances in molecular techniques have also helped redefine and reclassify rickettsias by maintaining some in the order Rickettsiales and placing others in other bacterial orders. The latter are still included in rickettsial reviews because of historical precedence. These molecular advances also help us to refine our knowledge of rickettsial pathogenesis.This volume is the first of two volumes to result from the 4th International Conference on Rickettsiae and Rickettsial Diseases, in which an effort is made to address and clarify issues from clinical, diagnostic, epidemiologic, and molecular perspectives that have remained unsolved in the past. In this volume, several subdisciplines of rickettsiology are included: genomics and proteomics, a protocol for naming newly isolated rickettsiae; bioterrorism; the pathobiology of reckettsial infections including Q (query) fever, antibiotic resistance, and vaccines; the discovery of new ricketsiae; and the pathobiology of Ehrlichia and Anaplasma infections. This volume. along with Century of Rickettsiology, which will be published in 2006 as an Annals volume, will provide a complete picture of the world-wide range of work that is currently being carried out in the field of rickettsiology.NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas.ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit www.nyas.org/membership/main.asp for more information about becoming a member.

Author Biography

Jose A. Oteo is the editor of Rickettsioses: From Genome to Proteome, Pathobiology, and Rickettsiae as an International Threat, Volume 1063, published by Wiley. Karim E. Hechemy is the editor of Rickettsioses: From Genome to Proteome, Pathobiology, and Rickettsiae as an International Threat, Volume 1063, published by Wiley.

Table of Contents

New Insights into Rickettsioses: Genomics, Proteomics, Pathobiology, and the International Threat of Rickettsial Diseases: Introduction	xiii
Karim E. Hechemy
Jose A. Oteo
Didier Raoult
David J. Silverman
Jose Ramon Blanco
Naming of Rickettsiae and Rickettsial Diseases	1	(12)
Didier Raoult
Pierre-Edouard Fournier
Marina Eremeeva
Stephen Graves
Patrick J. Kelly
Jose A. Oteo
Zuzana Sekeyova
Akira Tamura
Irina Tarasevich
Lijuan Zhang
Part I. Genomics and Proteomics
Progress in Rickettsial Genome Analysis from Pioneering of Rickettsia prowazekii to the Recent Rickettsia typhi	13	(13)
David H. Walker
Xue-Jie Yu
Rickettsia felis, from Culture to Genome Sequencing	26	(9)
H. Ogata
C. Robert
S. Audic
S. Robineau
G. Blanc
P.E. Fournier
P. Renesto
J.M. Claverie
D. Raoult
Dissecting the Rickettsia prowazekii Genome: Genetic and Proteomic Approaches	35	(12)
Aimee M. Tucker
Lewis K. Pannell
David O. Wood
New Perspectives on Rickettsial Evolution from New Genome Sequences of Rickettsia, particularly R. canadensis, and Orientia tsutsugamishi	47	(17)
Marina E. Eremeeva
Anup Madan
Chris Shaw
Kevin Tang
Gregory A. Dasch
Preliminary Assessment of Genome Differences between the Reference Nine Mile Isolate and Two Human Endocarditis Isolates of Coxiella burnetii	64	(4)
Paul A. Beare
Stephen F. Porcella
Rekha Seshadri
James E. Samuel
Robert A. Heinzen
Fur-Regulated Genes in Coxiella burnetti	68	(5)
Heather L. Briggs
Mary J. Wilson
Rekha Seshadri
James E. Samuel
A Minimal Set of DNA Repair Genes is Sufficient for Survival of Coxiella burnetii under Oxidative Stress	73	(3)
K. Mertens
L. Lantsheer
J.E. Samuel
Identification, Cloning, and Expression of Potential Diagnostic Markers for Q Fever	76	(3)
C.C. Chao
H.W. Chen
X. Li
W.B. Xu
B. Hanson
W.M. Ching
Preliminary Transcriptional Analysis of spoT Gene Family and of Membrane Proteins in Rickettsia conorii and Rickettsia felis	79	(4)
C. Rovery
M.V. La
S. Robineau
K. Matsumoto
P. Renesto
D. Raoult
Phylogenic Analysis of Rickettsial Patatin-like Protein with Conserved Phospholipase A2 Active Sites	83	(4)
Guillaume Blanc
Patricia Renesto
Didier Raoult
Proteomic Analysis of Rickettsia prowazekii	87	(3)
C.C. Chao
D. Chelius
T. Zhang
E. Mutumanje
W.M. Ching
Rickettsia conorii and R. prowazekii Proteome Analysis by 2DE-MS: A Step Toward Functional Analysis of Rickettsial Genomes	90	(4)
Patricia Renesto
Said Azza
Alain Dolla
Patrick Fourquet
Guy Vestris
Jean-Pierre Gorvel
Didier Raoult
Phylogenetic Study of Rickettsia Species Using Sequences of the Auto-transporter Protein-Encoding Gene sca2	94	(6)
Maxime Ngwamidiba
Guillaume Blanc
Hiroyuki Ogata
Didier Raoult
Pierre-Edouard Fournier
Molecular Characterization of a Group of Proteins Containing Ankyrin Repeats in Orientia tsutsugamushi	100	(2)
Nam-Hyuk Cho
Jo-Min Kim
Eun-Kyung Kwon
Se-Yoon Kim
Seung-Hoon Han
Hyuk Chu
Jung-Hee Lee
Myung-Sik Choi
Ik-Sang Kim
Ehrlichia ruminantium: A Promiscuous Genome	102	(3)
Maria Allsopp
Helena Steyn
Erich Zweygarth
Basil Allsopp
Part II. Pathobiology of Q Fever Infection
Coxiella burnetii Infection	105	(10)
Jan Kazar
Coxiella burnetii Whole Cell Lysate Protein Identification by Mass Spectrometry and Tandem Mass Spectrometry	115	(8)
Ludovit Skultety
Lenka Hernychova
Rudolf Toman
Martin Hubalek
Katarina Slaba
Jana Zechovska
Veronika Stofanikova
Juraj Lenco
Jiri Stulik
Ales Macela
Replication of Coxiella burnetii Is Inhibited in CHO K-1 Cells Treated with Inhibitors of Cholesterol Metabolism	123	(7)
Dale Howe
Robert A. Heinzen
Protective Immunity against Q Fever Induced with a Recombinant P1 Antigen Fused with HspB of Coxiella burnetii	130	(13)
Qingfeng Li
Dongsheng Niu
Bohai Wen
Meiling Chen
Ling Qiu
Jingbo Zhang
Immunization Experiments with Recombinant Coxiella burnetii Proteins in a Murine Infection Model	143	(6)
Judith Tyczka
Sandra Eberling
Georg Baljer
Structural and Functional Characterization of the Glycan Antigens Involved in Immunobiology of Q Fever	149	(5)
Pavol Vadovic
Katarina Slaba
Marcela Fodorova
Ludovit Skultety
Rudolf Toman
Lack of Dendritic Cell Maturation Following Infection by Coxiella burnetii Synthesizing Different Lipopolysaccharide Chemotypes	154	(7)
Jeffrey G. Shannon
Dale Howe
Robert A. Heinzen
TLR2 Is Necessary to Inflammatory Response in Coxiella burnetii Infection	161	(6)
Soraya Meghari
Amelie Honstettre
Hubert Lepidi
Bernardt Ryffel
Didier Raoult
Jean-Louis Megea
Comparative Virulence of Phase I and II Coxiella burnetii in Immunodeficient Mice	167	(4)
Masako Andoh
Kasi E. Russell-Lodrigue
Guoquan Zhang
James E. Samuel
Balb/c Mouse Model and Real-Time Quantitative Polymerase Chain Reaction for Evaluation of the Immunoprotectivity against Q Fever	171	(5)
Jingbo Zhang
Bohai Wen
Meiling Chen
Jun Zhang
Dongsheng Niu
Hepatitis Associated with C. burnetii Isolates	176	(5)
K.E. Russell-Lodrigue
M.W.J. Poels
G.Q. Zhang
D.N. McMurray
J.E. Samuel
Q Fever Research Group (QRG), Adelaide: Activities-Exit Summary 1980--2004	181	(6)
B. Marmion
R. Harris
P. Storm
K. Helbig
I. Penttila
D. Worswick
L. Semendric
Part III. Pathobiology of Rickettsial Infection, Antibiotic Resistance, and Vaccines
Rickettsial Infections	187	(10)
Juan P. Olano
The Presence of Eschars, but Not Greater Severity, in Portuguese Patients infected with Israeli Spotted Fever	197	(6)
Rita De Sousa
Nahed Ismail
Sonia Doria-Nobrega
Pedro Costa
Tiago Abreu
Ana Franca
Mario Amaro
Paula Proenca
Paula Brito
Jose Pocas
Teresa Ramos
Graca Cristina
Graca Pombo
Lilian Vitorino
Jorge Torgal
Fatima Bacellar
David Walker
Similarities and Differences in Host Cell Signaling following Infection with Different Rickettsia Species	203	(4)
Elena Rydkina
David J. Silverman
Sanjeev K. Sahni
Potential Roles for Regulatory Oxygenases in Rickettsial Pathogenesis	207	(8)
Sanjeev K. Sahni
Elena Rydkina
Abha Sahni
Suresh G. Joshi
David J. Silverman
Growth of Typhus Group and Spotted Fever Group Rickettsiae in Insect Cells	215	(7)
Tsuneo Uchiyama
Genome Comparison Analysis of Molecular Mechanisms of Resistance to Antibiotics in the Rickettsia Genus	222	(9)
J.M. Rolain
D. Raoult
Cloning and Sequence Analysis of the 22-kDa Antigen Genes of Orientia tsutsugamushi Strains Kato, TA763, AFSC 7, 18-032460, TH1814, and MAK 119	231	(8)
Hong Ge
Min Tong
Andrew Li
Rajan Mehta
Wei-Mei Ching
Nitric Oxide as a Mediator of Increased Microvascular Permeability during Acute Rickettsioses	239	(7)
Michael E. Woods
Gary Wen
Juan P. Olano
Cloning and Expression of 51-kDa Antigenic Protein of Neorickettsia risticii NR-JA1	246	(6)
Myeong-Kyu Park
Eun-Ha Kim
Mae-Rim Cho
Ying-Hua Yi
Mi-Jin Lee
Devendra H. Shah
Jin-Ho Park
Bae-Keun Park
Seong-Kug Eo
John-Hwa Lee
Joon-Seok Chae
Activity of Telithromycin against Thirteen New Isolates of C. burnetii Including Three Resistant to Doxycycline	252	(5)
Jean-Marc Rolain
Frederic Lambert
Didier Raoult
Effect of Antibiotic Treatment in Patients with DEBONEL/TIBOLA	257	(2)
V. Ibarra
J.R. Blanco
A. Portillo
S. Santibanez
L. Metola
J.A. Oteo
Structural Features of Lipopolysaccharide from Rickettsia Typhi: The Causative Agent of Endemic Typhus	259	(2)
Marcela Fodorova
Pavol Vadovic
Ludovit Skultety
Katarina Slaba
Rudolf Toman
Analysis of Immunoprotectivity of the Recombinant OmpA of Rickettsia heilongjiangensis	261	(5)
Yanmei Jiao
Bohai Wen
Meiling Chen
Dongsheng Niu
Jun Zhang
Ling Qiu
Short- and Long-Term Immune Responses of CD-1 Outbred Mice to the Scrub Typhus DNA Vaccine Candidate: p47Kp	266	(4)
Guang Xu
Suchismita Chattopadhyay
Ju Jiang
Teik-Chye Chan
Chien-Chung Chao
Wei-Mei Ching
Allen L. Richards
Part IV. Bartonella
Bartonellae as Elegant Hemotrophic Parasites	270	(10)
Richard J. Birtles
Production of Recombinant Protein Pap31 and Its Application for the Diagnosis of Bartonella bacilliformis Infection	280	(6)
A. Taye
H. Chen
K. Duncan
Z. Zhang
L. Hendrix
J. Gonzalez
W. Ching
Bartonella bacilliformis GroEL: Effect on Growth of Human Vascular Endo-thelial Cells in Infected Cocultures	286	(13)
Laura S. Smitherman
Michael F. Minnick
Occurrence of Bartonella henselae and Bartonella quintana among Human Immunodeficiency Virus--Infected Patients	299	(3)
M. Pape
P. Kollaras
K. Mandraveli
A. Tsona
S. Metallidis
P. Nikolaidis
S. Alexiou-Daniel
Bacillary Angiomatosis Caused by Bartonella quintana	302	(6)
Montserrat Sala
Bernat Font
Isabel Sanfeliu
Mariela Quesada
Imma Ponts
Ferran Segura
Molecular Screening of Bartonella Species in Rodents from the Russian Far East	308	(4)
Oleg Mediannikov
Leonid Ivanov
Nina Zdanovskaya
Nelya Vysochina
Pierre-Edouard Fournier
Irina Tarasevich
Didier Raoult
Characterization of Genes Involved in Long-Term Bacteremia in Mice by Bartonella birtlesii	312	(3)
Maria Mavris
Henri Saenz
Martine Monteil
Henri-Jean Boulouis
Christoph Dehio
Muriel Vayssier-Taussat
Part V. New Rickettsiae or Rickettsiae Not Previously or Recently Known to Cause Human Infection
Rickettsia parkeri as a Paradigm for Multiple Causes of Tick-Borne Spotted Fever in the Western Hemisphere	315	(12)
Christopher D. Paddock
Detection of a Typhus Group Rickettsia in Amblyomma Ticks in the State of Nuevo Leon, Mexico	327	(6)
Aaron Medina-Sanchez
Donald H. Bouyer
Virginia Alcantara-Rodriguez
Claudio Mafra
Jorge Zavala-Castro
Ted Whitworth
Vsevolod L. Popov
Ildefonso Fernandez-Salas
David H. Walker
Detection of a Non-Pathogenic Variant of Anaplasma phagocytophilum in Ixodes ricinus from La Rioja, Spain	333	(4)
A. Portillo
A.S. Santos
S. Santibanez
L. Perez-Martinez
J.R. Blanco
V. Ibarra
J.A. Oteo
Phylogenetic Analysis of a Novel Molecular Isolate of Spotted Fever Group Rickettsiae from Northern Peru: Candidatus Rickettsia andeanae	337	(6)
Ju Jiang
Patrick J. Blair
Vidal Felices
Cecilia Moron
Manuel Cespedes
Elizabeth Anaya
George B. Schoeler
John W. Sumner
James G. Olson
Allen L. Richards
Molecular and Biological Characterization of a Novel Coxiella-like Agent from Carios capensis	343	(3)
Will K. Reeves
Amanda D. Loftis
Rachael A. Priestley
William Wills
Felicia Sanders
Gregory A. Dasch
Debonel/Tibola: Is Rickettsia slovaca the Only Etiological Agent?	346	(3)
V. Ibarra
A. Portillo
S. Santibanez
J.R. Blanco
L. Perez-Martinez
J. Marquez
J.A. Oteo
Low Risk of Developing Human Rickettsia aeschlimannii Infection in the North of Spain	349	(3)
J.A. Oteo
A. Portillo
J.R. Blanco
V. Ibarra
L. Perez-Martinez
C. Izco
A. Perez-Palacios
S. Jimenez
Novel Spotted Fever Group Rickettsiae (SFGR) Infecting Amblyomma americanum Ticks in Ohio, USA	352	(4)
D.J. Kelly
J.R. Carmichael
G.C. Booton
K.F. Poetter
P.A. Fuerst
Old and New Human Rickettsiosis in Minas Gerais State, Brazil	356	(2)
S.B. Calic
C.M. Barcellos-Rocha
R.C. Leite
C.L. Mafra
M.A.M. Galvao
Ehrlichia ruminantium: An Emerging Human Pathogen?	358	(3)
M.T.E.P. Allsopp
M. Louw
E. C. Meyer
Part VI. Pathobiology of Ehrlichia and Anaplasma Infections
Anaplasma and Ehrlichia Infection	361	(13)
J. Stephen Dumler
The Interactions of Anaplasma phagocytophilum, Endothelial Cells, and Human Neutrophils	374	(9)
Michael J. Herron
Marna E. Ericson
Timothy J. Kurtti
Ulrike G. Munderloh
Balancing Protective Immunity and Immunopathology: A Unifying Model of Monocytotropic Ehrlichiosis	383	(12)
Nahed Ismail
David H. Walker
Susceptibility and Resistance to Monocytic Ehrlichiosis in the Mouse	395	(8)
Gary M. Winslow
Constantine Bitsaktsis
Eric Yager
Overcoming Barriers to the Transformation of the Genus Ehrlichia	403	(8)
S. Wesley Long
Ted J. Whitworth
David H. Walker
Xue-Jie Yu
Mechanisms of Immunological Control of Anaplasma phagocytophilum in Mice	411	(2)
Christina Rinkler
Yvonne Kern
Christian Bogdan
Friederike D. Von Loewenich
Platelet Dysfunction after Association with Anaplasma phagocytophilum in Vitro	413	(3)
Dori L. Borjesson
Jennifer L. Brazzell
Regina Feferman
Anaplasma phagocytophilum Infection Reduces Expression of Phagocytosis-Related Receptors on Neutrophils	416	(4)
Justin W.A. Garyu
J. Stephen Dumler
Analysis of Ehrlichial p28 Gene Expression in a Murine Model of Persistent Infection	420	(5)
Patricia A. Crocquet-Valdes
Jere W. McBride
Hui-Min Feng
Nahed Ismail
Melissa A. Small
Xue-Jie Yu
David H. Walker
Innate Immune Tissue Injury and Murine HGA: Tissue Injury in the Murine Model of Granulocytic Anaplasmosis Relates to Host Innate Immune Response and Not Pathogen Load	425	(4)
Diana G. Scorpio
Friederike D. Von Loewenich
Christian Bogdan
J. Stephen Dumler
Cytokine Responses in Dogs Infected with Ehrlichia canis Oklahoma Strain	429	(4)
Tomoko Tajima
Yasuko Rikihisa
Molecular Characterization of E. canis gp36 and E. chaffeensis gp47 Tandem Repeats among Isolates from Different Geographic Locations	433	(3)
C. Kuyler Doyle
Ana Maria Cardenas
Daniel M. Aguiar
Marcelo B. Labruna
Lucy M. Ndip
Xue-Jie Yu
Jere W. McBride
Prophylactic Use of Sustained-Release Doxycycline Blocks Tick-Transmitted Infection by Anaplasma phagocytophilum in a Murine Model	436	(3)
Robert F. Massung
Nordin S. Zeidner
Marc C. Dolan
Dawn Roellig
Elizabeth Gabitzsch
Danielle R. Troughton
Michael L. Levin
Concentration of Procalcitonin and C-Reactive Protein in Patients with Human Granulocytic Anaplasmosis and the Initial Phase of Tick-Borne Encephalitis	439	(3)
Stanka Lotric-Furlan
Tereza Rojko
Franc Strle
Part VII. Ricketsiae Agents of Bioterrorism
Genome Analysis of Coxiella burnetii Species: Insights into Pathogenesis and Evolution and Implications for Biodefense	442	(9)
Rekha Seshadri
James Samuel
Attack Scenarios with Rickettsial Species: Implications for Response and Management	451	(8)
G. Pappas
N. Akritidis
E. Tsianos
The Pathogen Resource Integration Center: Implications for Rickettsial Research	459	(7)
Mark E. Hance
Michael J. Czar
Abdu Azad
Anjan Purkayastha
Eric E. Snyder
Oswald R. Crasta
Joao C. Setubal
Bruno W. Sobral
Evaluation of Low Concentration Aerosol for Infecting of the Man by Q Fever Pathogen	466	(5)
Eugene Vorobeychikov
Alexander Vasilenko
Nikolay Tokarevich
Ludmila Yakovleva
Boris Nikolaev
Index of Contributors	471