Risk Assessment With Time to Event Models

by Crane; Mark

• ISBN13: 9781566705820
• ISBN10: 1566705827
• Edition: 1st
• Format: Hardcover
• Copyright: 2001-12-04
• Publisher: CRC Press

Summary

How can environmental regulators use information on 48-hour toxicity tests to predict the effects of a few minutes of pollution? Or, at the other extreme, what is the relevance of 96-hour toxicity data for organisms that may have been exposed to a pollutant for six months or more? Time to event methods are the key to answering these types of questions. Risk Assessment with Time to Event Models is the first comprehensive treatment of these methods in the context of ecological risk assessment. Leading experts from industry, academia, and government regulatory agencies explain how these methods can be used to extract more useful information from laboratory data than is present in simple summary statistics like 48-h LC50. The book offers a clear introduction to the field through several approaches, from the introductory to the more mathematical. Risk Assessment with Time to Event Models demonstrates the relevance of time in the analysis and reporting of toxicity data through the use of practical examples from the field of environmental toxicology. It also incorporates helpful analogies from other disciplines that commonly use time to event modeling.

Table of Contents

Introduction to time to event methods	1	(6)
Michael C. Newman
Mark Crane
Time to event analysis of standard ecotoxicity data	7	(16)
Mark Crane
Albania Grosso
Applying time to event methods to assess pollutant effects on populations	23	(16)
Michael C. Newman
John T. McCloskey
Time-concentration-effect models in predicting chronic toxicity from acute toxicity data	39	(30)
Foster L. Mayer
Mark R. Ellersieck
Gary F. Krause
Kai Sun
Gunhee Lee
Denny R. Buckler
Just how much better is a time to event analysis?	69	(20)
Philip M. Dixon
Using time to event modeling to assess the ecological risk of produced water discharges	89	(14)
Chris C. Karman
Time to event analysis in the agricultural sciences	103	(18)
John S. Fenlon
Time to event analysis in ecology	121	(20)
Bryan F.J. Manly
Time to event analysis in engineering	141	(12)
Alan Kimber
Can risk assessment be improved with time to event models?	153	(14)
Mark Crane
Peter F. Chapman
Tim Sparks
John Fenlon
Michael C. Newman
Conclusions	167	(4)
Mark Crane
Peter F. Chapman
Michael C. Newman
Index	171