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9780471771517

RNA Interference Application to Drug Discovery and Challenges to Pharmaceutical Development

by ;
  • ISBN13:

    9780471771517

  • ISBN10:

    0471771511

  • Edition: 1st
  • Format: Hardcover
  • Copyright: 2011-02-15
  • Publisher: Wiley

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Summary

RNA Interference: Application to Drug Discovery and Challenges to Pharmaceutical Development provides a general overview of this rapidly emerging field, with a strong emphasis on issues and aspects that are important to a drug development team. The first part covers more general background of RNA interference and its application in drug discovery. In the second part, the book addresses siRNA (small interfering RNA), a pharmaceutically potent form, and its use and delivery in therapeutics along with manufacturing and delivery aspects.

Author Biography

Paul H. Johnson, PhD, is a cofounder and Chief Scientific Officer at PhaseRX, Inc. He is the author of numerous scientific papers and patents, and was the recipient of the 2007 Jeffery Wenig Memorial Award for Outstanding Achievement in Drug Delivery.

Table of Contents

Biology of RNA Interference
RNA interference: What is it?
Nucleic acids as regulatory molecules
Use of siRNA oligonucleotides to study gene function
Genome scanning by RNA interference
Development of siRNA for Therapeutic Applications
Discovery of new siRNA delivery agents
In vivo Delivery of siRNA: challenges and strategies
Interferon, cytokine induction and other potential in vivo toxicities
Application of RNA interference to viral diseases
Table of Contents provided by Publisher. All Rights Reserved.

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