The Rna World

by Gesteland, Raymond F.; Cech, Thomas R.; Atkins, John F.

• ISBN13: 9780879695613
• ISBN10: 0879695617
• Edition: 2nd
• Format: Paperback
• Copyright: 1999-02-01
• Publisher: Cold Spring Harbor Laboratory Pr

Table of Contents

Preface	ix
Foreword to the First Edition	xiii
Francis Crick
Prologue to the First Edition	xvii
James D. Watson
THE ORIGINS OF RNA AND RNA AT THE ORIGIN
Before RNA and After: Geophysical and Geochemical Constraints on Molecular Evolution	1	(48)
Stephen J. Mojzsis
Ramanarayanan Krishnamurthy
Gustaf Arrhenius
Prospects for Understanding the Origin of the RNA World	49	(30)
Gerald F. Joyce
Leslie E. Orgel
The Genomic Tag Hypothesis: What Molecular Fossils Tell Us about the Evolution of tRNA	79	(34)
Nancy Maizels
Alan M. Weiner
Probing RNA Structure, Function, and History by Comparative Analysis	113	(30)
Norman R. Pace
Brian C. Thomas
Carl R. Woese
Re-creating an RNA Replicase	143	(20)
David P. Bartel
Did the RNA World Exploit an Expanded Genetic Alphabet?	163	(20)
Steven A. Benner
Petra Burgstaller
Thomas R. Battersby
Simona Jurczyk
Aminoacyl-tRNA Synthetases and Self-acylating Ribozymes	183	(14)
Michael Yarus
Mali Illangasekare
On the Origin of the Ribosome: Coevolution of Subdomains of tRNA and rRNA	197	(24)
Harry F. Noller
Introns and the RNA World	221	(12)
Walter Gilbert
Sandro J. de Souza
HOW TO BUILD A FUNCTIONAL RNA
The Interactions That Shape RNA Structure	233	(32)
Mark E. Burkard
Douglas H. Turner
Ignacio Tinoco, Jr.
Small Ribozymes	265	(22)
David B. McKay
Joseph E. Wedekind
The Role of Metal Ions in RNA Biochemistry	287	(34)
Andrew L. Feig
Olke C. Uhlenbeck
Building a Catalytic Active Site Using Only RNA	321	(30)
Thomas R. Cech
Barbara L. Golden
Ribonuclease P	351	(30)
Sidney Altman
Leif Kirsebom
The RNA Folding Problem	381	(22)
Peter B. Moore
TRANSITION TO THE RNP WORLD
RNA Interaction with Small Ligands and Peptides	403	(24)
Joseph D. Puglisi
James R. Williamson
RNA Recognition by Proteins	427	(24)
Thomas A. Steitz
Group I and Group II Ribozymes as RNPs: Clues to the Past and Guides to the Future	451	(36)
Alan M. Lambowitz
Mark G. Caprara
Steven Zimmerly
Philip S. Perlman
The Growing World of Small Nuclear Ribonucleoproteins	487	(38)
Yi-Tao Yu
Elizabeth C. Scharl
Christine M. Smith
Joan A. Steitz
Splicing of Precursors to mRNAs by the Spliceosomes	525	(36)
Christopher B. Burge
Thomas Tuschl
Philip A. Sharp
tRNA Splicing: An RNA World Add-on or an Ancient Reaction?	561	(24)
Christopher R. Trotta
John Abelson
RNA Editing---An Evolutionary Perspective	585	(24)
Larry Simpson
Telomerase	609	(28)
Elizabeth H. Blackburn
Dynamics of the Genetic Code	637	(60)
John F. Atkins
August Bock
Senya Matsufuji
Raymond F. Gesteland
APPENDICES
1 Structures of Base Pairs Involving at Least Two Hydrogen Bonds	675	(6)
Mark E. Burkard
Douglas H. Turner
Ignacio Tinoco, Jr.
2 Schematic Diagrams of Secondary and Tertiary Structure Elements	681	(6)
Mark E. Burkard
Douglas H. Turner
Ignacio Tinoco, Jr.
3 Reactions Catalyzed by RNA and DNA Enzymes	687	(4)
Gerald F. Joyce
4 Visualization of Elongation Factor Tu on the 70S E. coli Ribosome	691	(4)
Holger Stark
Marin van Heel
Marina Rodnina
Wolfgang Wintermeyer
Richard Brimacombe
5 The Large Ribosomal Subunit from H. marismortui at 9 A Resolution	695	(2)
Nenad Ban
Peter B. Moore
Thomas A. Steitz
Index	697