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List of Figures | p. ix |
Acknowledgments | p. xiii |
Introduction | p. 1 |
Robustness Below the Gene Level | p. 13 |
The Genetic Alphabet | p. 15 |
The Genetic Code | p. 25 |
RNA Structure | p. 39 |
Proteins and Point Mutations | p. 62 |
Proteins and Recombination | p. 78 |
Robustness Above the Gene Level | p. 91 |
Regulatory DNA Regions and Their Reorganization in Evolution | p. 93 |
Metabolic Pathways | p. 104 |
Metabolic Networks | p. 120 |
Drosophila Segmentation and Other Gene Regulatory Networks | p. 143 |
Phenotypic Traits, Cryptic Variation, and Human Diseases | p. 161 |
The Many Ways of Building the Same Body | p. 175 |
Common Principles | p. 193 |
Neutral Spaces | p. 195 |
Evolvability and Neutral Mutations | p. 217 |
Redundancy of Parts or Distributed Robustness? | p. 228 |
Robustness as an Evolved Adaptation to Mutations | p. 247 |
Robustness as an Evolved Adaptation to Environmental Change and Noise | p. 270 |
Robustness and Fragility: Advantages to Variation and Trade-offs | p. 281 |
Robustness Beyond the Organism | p. 295 |
Robustness in Natural Systems and Self-Organization | p. 297 |
Robustness in Man-made Systems | p. 310 |
Epilogue: Seven Open Questions for Systems Biology | p. 321 |
Bibliography | p. 323 |
Index | p. 359 |
Table of Contents provided by Publisher. All Rights Reserved. |
The New copy of this book will include any supplemental materials advertised. Please check the title of the book to determine if it should include any access cards, study guides, lab manuals, CDs, etc.
The Used, Rental and eBook copies of this book are not guaranteed to include any supplemental materials. Typically, only the book itself is included. This is true even if the title states it includes any access cards, study guides, lab manuals, CDs, etc.