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9789400763166

Role of Capsaicin in Oxidative Stress and Cancer

by
  • ISBN13:

    9789400763166

  • ISBN10:

    9400763166

  • Format: Hardcover
  • Copyright: 2013-05-07
  • Publisher: Springer Nature
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Supplemental Materials

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Summary

This book describe the mechanism of the anti-cancer effects of capsaicin including the involvement of cytochrome P-450 in the bioactivation; identification of mitochondria as the key target site for oxidative stress; involvement of mitochondrial respiratory chain in the production of ROS; prevention of chemically-induced carcinogenesis, discussion on TRPV-1 receptor mediated or independent anti-cancer effects; identification of p53 activation as a possible mechanism; involvement of Cox-2 in apoptosis, suppression of transcription factors such as NF-kB and STAT-3; inhibition of cell survival pathways including PI3K/Akt and the involvement of intrinsic mitochondrial cell death pathway.

Supplemental Materials

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