The Role of DNA Damage and Repair in Cell Aging

by Gilchrest; Bohr

• ISBN13: 9780444504944
• ISBN10: 044450494X
• Edition: 1st
• Format: Hardcover
• Copyright: 2001-03-09
• Publisher: Elsevier Science

Summary

Aging occurs at the level of individual cells, a complex interplay between intrinsic programming and exogenous wear and tear, with genetically-determined cellular capacity to repair environmentally-induced DNA damage playing a central role in the rate of aging and its specific manifestations. In 12 chapters, The Role of DNA Damage and Repair in Cell Aging provides an intellectual framework for aging of mitotic and post-mitotic cells, describes a variety of model systems for further studies, and reviews current concepts of DNA responses and their relationship to the phenomenon of aging.As part of a series entitled Advances in Cell Aging and Gerontology, this volume also summarizes seminal recent discoveries such as the molecular basis for Werner syndrome (a mutant DNA helicase), the complementary roles of telomere shortening and telomerase activity in cell senescence versus immortalization, the role of apoptosis in the homeostasis of aging tissue, and the existence of an inducible SOS-like response in mammalian cells that minimizes DNA damage from repeatedly encountered injurious environmental agents. Insights into the relationship between cellular aging and age-associated diseases, particularly malignancies, are also provided in several chapters.This book is an excellent single source of information for anyone interested in DNA repair, mechanisms of aging, or certainly their intersection. Students will gain a general appreciation of these fields, but even the most senior investigators will benefit from the detailed coverage of rapidly advancing areas.

Table of Contents

Introduction	vii
Aging in Mitotic and Post-Mitotic Cells	1	(16)
J. Campisi
H.R. Warner
Age-Associated Changes in DNA Repair and Mutation Rates	17	(14)
L. Grossman
S.-I. Moriwaki
S. Ray
R.E. Tarone
Qingyi Wei
K.H. Kraemer
Relationship of DNA Repair Capacity to Species Lifespan	31	(10)
R. W. Hart
A. Turturro
S.Y. Li
DNA Base Modifications in Aging	41	(32)
J.W. Gaubatz
Models for Studyding Genomic Instability During Aging	73	(18)
J. Vijg
H. Giese
M.E.T. Dolle
Effects of Aging on Gene Specific Repair	91	(22)
A. Richardson
ZhongMao Guo
Poly(ADP-Ribose) Polymerase and Aging	113	(22)
D.S. Rosenthal
C.M. Simbulan-Rosenthal
Wen Fang Liu
M.E. Smulson
DNA Instability, Telomere Dynamics, and Cell Transformation	135	(18)
R.J. Shmookler Reis
M.A. Shammas
Commitment Signalling for Apoptosis, or DNA Repair and Its Relevance to Aging and Age-Dependent Diseases	153	(38)
E. Wang
R. Marcotte
H.T. Papaconstantinou
J. Papaconstantinou
DNA Damage and Its Processing with Aging: Human Premature Aging Syndromes as Model Systems	191	(16)
V.A. Bohr
Gene Action at the Werner Helicase Locus: Its Role in the Pathobiology of Aging	207	(20)
J. Oshima
G.M. Martin
M.D. Gray
M. Poot
P.S. Rabinovitch
Inducible Photoprotection in Skin: Evidence for a Eukaryotic Sos Response	227	(28)
M.S. Eller
B.A. Gilchrest
List of Contributors	255