Salivary Diagnostics

by Wong, David T.

• ISBN13: 9780813813332
• ISBN10: 0813813336
• Edition: 1st
• Format: Hardcover
• Copyright: 2008-11-11
• Publisher: Wiley-Blackwell

Summary

Salivary Diagnostics surveys one of the most exciting areas of research in oral biology. Regarded as the mirror of the body, saliva has immense potential to yield real clinical improvements in our ability to diagnose, and hence treat, oral and systemic conditions. The composition of saliva and other oral fluids reflect the tissue fluid levels of therapeutic, hormonal, and immunological molecules, as well as the presence of markers for systemic and oral disease. Salivary Diagnostics describes the nature of saliva, and the basis for its usefulness as a diagnostic fluid. The book then goes on to survey and review the field of research, moving on to detail the development of current technologies and the deciphering of the human salivary proteome. Saliva Diagnostics will be essential to researchers in this field, oral biologists, and pathologists, as well as physicians and dentists and those involved with laboratory diagnostics in an academic and commercial setting. Salivary Diagnostics brings together the leading experts in the field under the aegis of a luminary editor. This book represents an unparalleled guide to the academic, scientific, clinical, and commercial applications of saliva as a diagnostic fluid.

Author Biography

David Wong heads the leading team in this field. He has received several multi-million dollar grants from the NIH to further his research. His background is in dentistry, as are those of many of the proposed contributors.

Table of Contents

Contributors	p. viii
Foreword	p. xv
Preface	p. xvii
Acknowledgment	p. xviii
Background and Foundation
Salivary Gland Development and Regeneration	p. 3
Salivary Gland Physiology Relevant to Diagnostics	p. 14
Saliva: Properties and Functions	p. 27
Saliva Collectors	p. 37
Salivary Secretion in Health and Disease	p. 60
Processing and Storage of Saliva Samples	p. 69
Saliva Diagnostics
Historical Perspectives and Present	p. 79
Diagnostics Other Than Blood	p. 94
Perceptions of Saliva: Relevance to Clinical Diagnostics	p. 104
Saliva-Based Diagnostic Technologies: Highlights of the NIDCR's Program	p. 111
Human Salivary Proteomics	p. 122
Genomic Targets in Saliva	p. 129
Point-of-Care Diagnostics for Infectious diseases	p. 136
Dental Caries Risk Assessment	p. 150
Periodontal Disease	p. 156
Role of Saliva in Detection of Substance Abuse	p. 169
Head and Neck Cancer	p. 180
Sjogren's Syndrome	p. 189
Salivary Gland Dysfunction Associated with Systemic Disease	p. 198
Progression and Treatment Evaluation in Diseases Affecting Salivary Glands	p. 214
The Uses of Saliva in Forensic Genetics	p. 226
SPKB-Salivary Proteome Knowledge Base: A Platform for Collaborative Proteomics Research	p. 233
Saliva Diagnostics-A New Industry
Commercialization of Oral Fluid Products and Technologies	p. 243
Coverage and Reimbursement for Salivary Diagnostic Tests	p. 255
Saliva Diagnostics in the Dentist's and Physician's Office	p. 263
Salivary Hormones in Research and Diagnostics	p. 270
Crossroads Between Saliva Diagnostics and Salivary Gland Gene Therapy	p. 278
Saliva Diagnostics-A New Industry	p. 288
Index	p. 295
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