Samter's Immunologic Diseases

by Austen, K. Frank; Frank, Michael M., M.D.; Cantor, Harvey I., M.D.; Atkinson, John P., M.D.

• ISBN13: 9780781721202
• ISBN10: 0781721202
• Edition: 6th
• Format: Hardcover
• Copyright: 2001-09-01
• Publisher: Lippincott Williams & Wilkins

Summary

The thoroughly updated Sixth Edition of this classic two-volume work continues to provide a comprehensive overview of immunology, its clinical applications, immunopathology, and allergy. A text revised and updated throughout facilitates an understanding of the host mechanisms in immunologic diseases. The strength of this text is its clinically oriented emphasis on immunologic diseases and differential approach to symptoms and syndromes. This edition features an increased clinical coverage and is an essential reference for all clinical immunologists, rheumatologists, and allergists. It will include a CD-ROM bound in the back of the book. A Brandon-Hill recommended title.

Table of Contents

Contributor's List	ix
Preface	xv
Section I. Recognition: Innate and Adaptive Immunity	12
Innate Immunity: Linkages to Adaptive Responses	1
Robert A. Barrington
Elahna Paul
Michael C. Carroll
Architecture of the Immune System	10
Garnett Kelsoe
Laura P. Hale
MHC: Structure and Function	23
Hidde Ploegh
T-Cell Antigen Receptors	31
Mark M. Davis
Yueh-Hsiu Chien
T-Cell Biology and the Thymus	43
Jonathan Sprent
Charles D. Surh
Antigen Processing and Presentation	53
Emil R. Unanue
Immunogenicity and Antigenicity	65
Jay A. Berzofsky
Lymphocyte Signaling	82
Lyse A. Norian
Gary Koretsky
T-Lymphocyte Activation, Constimulation, and Tolerance: Signals, Mechanisms, and Clinical Applications	94
Rebecca J. Greenwald
Arlene H. Sharpe
Abul Abbas
Cytokines and Type 1 Immunity	104
J. David Farrar
Kenneth M. Murphy
Cytokine Regulation of Type 2 Immunity	111
Fred Douglas Finkelman
Apoptosis and the Immune Response	127
Douglas R. Green
Antibodies and Their Receptors	136
Rafael Casellas
Michel C. Nussenzweig
Biology of B Cells	146
Norman R. Klinman
Adhesion Molecules	155
Michael L. Dustin
Chemokines and Chemokine Receptors	166
Andrew D. Luster
Hematopoietic Cytokines	175
E. Richard Stanley
Section II. Effector Mechanisms: Innate and Adaptive
T-Lymphocyte Effector Activity	195
Thomas J. Braciale
Steven M. Varga
Natural Killer Cells	206
Lewis L. Lanier
Neutrophils	210
Helene F. Rosenberg
John I. Gallin
Monocytes and Macrophages	221
Iain P. Fraser
R. Alan B. Ezekowitz
Eosinophils	235
Peter F. Weller
Basophils	244
Bruce S. Bochner
John Schroeder
Biology of the Mast Cell	253
Joshua A. Boyce
K. Frank Austen
Immune Complexes	270
Mark J. Walport
Kevin A. Davies
Complement System	281
Michael M. Frank
John P. Atkinson
Arachidonic Acid Pathways	299
John F. Penrose
K. Frank Austen
Section III. Primary Immunodeficiencies
Primary Immunodeficiencies of Lymphocytes	317
Rebecca H. Buckley
Phagocyte Disorders	329
Steven M. Holland
John I. Gallin
Complement in Disease: Inherited and Acquired Complement Deficiencies	349
John P. Atkinson
Michael M. Frank
Section IV. Proliferation Disorders of Immunologic Cells
Lymphocytic Lymphomas and Hodgkin's Disease	359
Eric H. Westin
Dan L. Longo
Multiple Myeloma	379
Jean-Claude Brouet
Jean-Paul Fermand
Macroglobulinemia	392
Nancy L. Bartlett
Sophia M. Arackal
Amyloidosis	401
Mark B. Pepys
Philip N. Hawkins
Eosinophilia	412
Peter F. Weller
Mastocytosis	420
Dean D. Metcalfe
Index	I-1
Section V. Systemic Diseases
Rheumatoid Arthritis	427
Percio S. Gulko
Robert Winchester
Juvenile Rheumatoid Arthritis	463
Alexei A. Grom
David N. Glass
Systemic Lupus Erythematosus	475
George Vratsanos
Insoo Kang
Joe Craft
Sjogren's Syndrome	495
Roland Jonsson
Karl A. Brokstad
Systemic Sclerosis (Scleroderma)	504
Richard M. Silver
Marcy B. Bolster
Idiopathic Inflammatory Myopathies: Dermatomyositis, Polymyositis, and Related Disorders	520
Lauren M. Pachman
Frederick W. Miller
The Spondyloarthropathies	531
Hani S. El-Gabalawy
Peter E. Lipsky
Rheumatic Fever and Other Cardiovascular Disease	546
Clifford J. Kavinsky
Joseph E. Parrillo
Vasculitis	560
Paul Katz
Antiphospholipid Syndrome	571
Stephen Reddel
Steven Krilis
Sarcoidosis	579
A. Brent Carter
Gary W. Hunninghake
Section VI. Organ-Specific Diseases
Diabetes Mellitus	587
Norio Abiru
David T. Robles
George S. Eisenbarth
Autoimmune Thyroid Disease, Addison Disease, and Autoimmune Polyglandular Syndromes	605
Ramzi A. Ajjan
A. P. Weetman
Immunologic Renal Disease	627
Mary H. Foster
Myasthenia Gravis	650
John W. Rose
Dale McFarlin
Autoimmune Blistering Mucocutaneous Diseases	665
Hossein C. Nousari
Grant J. Anhalt
Immune Function in Ocular Inflammatory Disease	672
Thomas A. Ferguson
Russell N. Van Gelder
Autoimmune Hepatobiliary Diseases	681
Stephen P. James
Immunolog Diseases of the Gastrointestinal Tract	693
William F. Stenson
Rodney D. Newberry
Robin G. Lorenz
Multiple Sclerosis	711
Amit Bar-Or
Kevin C. O'Connor
David Haffler
Autoimmune Hemolytic Anemia	738
Alan D. Schreiber
Immune Thrombocytopenia	749
Russell E. Ware
Blood Groups, Immunologic Hazards of Transfusion, and Hemolytic Disease of the Newborn	758
Marilyn J. Telen
Immunological Aspects of Fertility and Infertility	771
Joan S. Hunt
Kenneth S. K. Tung
Section VII. Allergic Diseases
Allergens	787
Judith A. Woodfolk
Thomas A. E. Platts-Mills
Genetics of Allergic Disease	810
Deborah A. Meyers
Timothy D. Howard
Eugene R. Bleecker
Allergic Rhinitis	817
Philip S. Norman
Anaphylactic Syndrome	825
Alexandra Worobec
Dean D. Metcalfe
Asthma	836
Mark D. Steel
Stephen T. Holgate
Urticaria and Angioedema: Pathogenesis, Assessment, and Treatment	865
Allen P. Kaplan
Atopic Dermatitis	877
Donald Y. M. Leung
Mark Boguniewicz
Allergic Reactions to Foods	890
Dean D. Metcalfe
Insect Venom Allergy	897
Martin D. Valentine
Immunologic Lung Disease	903
Michael B. Levy
Jordan N. Fink
Allergic Contact Dermatitis	915
Stephen I. Katz
Allergic Reactions to Drugs	921
Rebecca S. Gruchalla
Natural Rubber Latex Allergy	935
James A. MacLean
Section VIII. Evasion, Activation and Ineffective Immunity
Human Immunodeficiency Virus Infection	943
Oren J. Cohen
Anthony S. Fauci
Epstein-Barr Virus	970
David A. Thorley-Lawson
Tuberculosis and Leprosy	985
John D. McKinney
Barry R. Bloom
Robert L. Modlin
Cryopathies: Cryoglobulins and Cryofibrinogenemia	1002
Peter D. Gorevic
Viruses	1022
Michael B. A. Oldstone
Persephone Borrow
Lyme Disease	1041
Lisa Glickstein
Allen C. Steere
Parasitic Diseases	1050
Frederick P. Heinzel
Thomas B. Nutman
The Immunocompromised Host	1067
Catherine J. Wu
Jerome Ritz
Aging and the Immune System	1086
Marc E. Weksler
Paul Szabo
Section IX. Transplantation
Hematopoietic Stem Cell Transplantation	1095
Michael B. Maris
Rainer Storb
Tissue and Solid Organ Allograft Rejection	1121
Kim C. Lu
Andres Jaramillo
Thalachallour Mohamakumar
Immunology of Xenotransplantation	1132
Jeffrey L. Platt
Section X. Therapeutic Immunology
Calcineurin as a Therapeutic Target	1147
Anthony D. Castillo
Barbara E. Bierer
T-Cell Antigen and Costimulatory Receptors as Therapeutic Targets	1155
Maria-Luisa Alegre
Jeffrey A. Bluestone
Cytokines and Cancer Immunotherapy	1175
Glenn Dranoff
Anti-TNF-α Therapy in Rheumatoid Arthritis and Other Diseases	1180
Marc Feldman
Ravinder N. Maini
Use of Intravenous Immunoglobulin	1190
C. Garren Hester
Michael M. Frank
Monoclonal Antibody Therapy	1199
David W. Thomas
James W. Larrick
Drugs that Modulate the Immune Response	1213
Edwin S. L. Chan
Bruce N. Cronstein
New Approaches to Vaccine Development	1223
Gary J. Nabel
Appendicies
A. Methods	1229
Thomas A. Fleisher
B. Glossary	1247
Index	I-1