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Dr. John E. Morley, known internationally as a gerontological researcher, clinician, and educator, became the Director of the Division of Geriatric Medicine and the Dammert Professor of Gerontology. In addition to extensive personal scientific achievements, Dr. Morley has directed the clinical training programs in both endocrinology and geriatrics and supervised research activities ranging from basic biomedical investigation to epidemiology and health services research. He is the editor of the Journal of Gerontology: Medical Sciences, and recipient of the Ipsen Foundation of Longevity Award in 2001, the American Geriatrics Society's Lascher/Manning Award for Lifetime Achievement in Geriatrics in 2002, and the Gerontological Society of America's Freeman Award in 2004. He has developed a number of educational games and has a special interest in continuous quality improvement (CQI).
Preface xi
1 Epidemiology of Muscle Mass Loss with Age 1Marjolein Visser
2 Definitions of Sarcopenia 8John E. Morley and Alfonso J. Cruz-Jentoft
3 Muscle Biology and mTORC1 Signaling in Aging 20Blake B. Rasmussen and Elena Volpi
4 The Role of the Nervous System in Muscle Atrophy 41Minal Bhanushali, Robin Conwit, Jeffrey Metter and Luigi Ferrucci
5 Nutrition, Protein Turnover and Muscle Mass 59Stephane Walrand, Christelle Guillet and Yves Boirie
6 The Complex Relation between Muscle Mass and Muscle Strength 74Todd M. Manini, David W. Russ and Brian C. Clark
7 Is Sarcopenia a Geriatric Syndrome? 104Jean-Pierre Michel and Alfonso J. Cruz-Jentoft
8 Adverse Outcomes and Functional Consequences of Sarcopenia 114David R. Thomas
9 A Lifecourse Approach to Sarcopenia 125Avan Aihie Sayer
10 Cachexia and Sarcopenia 141Maurizio Muscaritoli, Simone Lucia and Filippo Rossi Fanelli
11 Sarcopenia and Frailty 154Cornel C. Sieber
12 Sarcopenia, Osteoporosis and Fractures 168Tommy Cederholm
13 Sarcopenic Obesity 181Mauro Zamboni, Andrea P. Rossi and Elena Zoico
14 Imaging of Skeletal Muscle 193Thomas F. Lang
15 Measurements of Muscle Mass, Equations and Cut-off Points 205Marjolein Visser and Laura Schaap
16 Measurement of Muscle Strength and Power 226Michael Drey and Jurgen M. Bauer
17 Measurements of Physical Performance 238Rolland Yves, Gabor Abellan van Kan and Matteo Cesari
18 Exercise Interventions to Improve Sarcopenia 252Mark D. Peterson and Jos´e A. Serra-Rexach
19 Nutritional Approaches to Treating Sarcopenia 275Douglas Paddon-Jones and Luc van Loon
20 The Future of Drug Treatments 296Francesco Landi, Yves Rolland and Graziano Onder
21 Sarcopenia: Is It Preventable? 324Maurits Vandewoude and Ivan Bautmans
Index 339
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