Scarless Wound Healing

by Rodrigues; A. David

• ISBN13: 9780824702854
• ISBN10: 0824702859
• Format: Hardcover
• Copyright: 2000-06-13
• Publisher: CRC Press

Summary

Applies recent molecular discoveries to the evolving treatment of skin therapy and points out future research areas. Presenting the most up-to-date research in wound treatment, this comprehensive reference analyzes the critical alterations in the composition and organization of the extracellular matrix following injury. Beginning with a chemicobiological history of wound healing and leading into a study of artificial wound coverings, the book progresses toward the application of fetal wound materials for adult scarless repair and the role of different macromolecules in wound repair. With nearly 40 recognized specialists addressing the most recent developments in wound care today, Scarless Wound Healing investigates the multifaceted role of hyaluronan in epithelial recovery the effects of changes in sulfation on skin proteoglycans distribution and composition changes of proteoglycans, including syndecans in scarring the role of the hyaluronan receptors RHAMM and CD44 in wound recovery the biology of fibroproliferative disorders the influence of transforming growth factors (TGF) to stimulate cell recovery fetal wound healing and more! Supplemented with over 1500 literature references, drawings, and tables, Scarless Wound Healing is invaluable reading for all plastic, reconstructive, cosmetic, maxillofacial, and general surgeons; dermatologists; glyco- and chemical biologists; and medical school students.

Table of Contents

Series Introduction	v
Preface	vii
Contributors	xiii
Chemistry of Scarring	1	(22)
Hari G. Garg
Christopher D. Warren
John W. Siebert
Modification of Proteodermatan/Chondroitin Sulfation and Its Potential for Affecting Scarring	23	(14)
Jeremiah E. Silbert
Syndecan Biology in Wound Repair	37	(26)
Richard L. Gallo
Merton Bernfield
Varpu Kainulainen
Integrin Regulation in Wound Repair	63	(36)
Jiahua Xu
Richard A. F. Clark
Collagen Considerations in Scarring and Regenerative Repair	99	(16)
H. Paul Ehrlich
The Role of Hyaluronan--Receptor Interactions in Wound Repair	115	(28)
Rashmin C. Savani
Darius J. Bagli
Rene E. Harrison
Eva A. Turley
Hyaluronan: Aiming for Perfect Skin Regeneration	143	(18)
Endre A. Balazs
Nancy E. Larsen
Molecular Mechanisms in Keloid Biology	161	(12)
William J. H. Kim
Howard Levinson
George K. Gittes
Michael T. Longaker
Molecular and Cellular Biology of Derman Fibroproliferative Disorders	173	(40)
Barbara S. Bauer
Edward E. Tredget
Paul G. Scott
Aziz Ghahary
The Role of Transforming Growth Factors--Beta in Cutaneous Scarring	213	(14)
Mamta Shah
Patricia Rorison
Mark W. J. Ferguson
Recent Advances in Embryonic Wound Healing	227	(12)
Alison M. Shaw
Characteristics of Fetal Wound Repair	239	(24)
Gyu S. Chin
Eric J. Stelnicki
George K. Gittes
Michael T. Longaker
Facts and Models of Induced Organ Regeneration: Skin and Peripheral Nerves	263	(16)
Ioannis V. Yannas
Clinical Use of Skin Substitutes	279	(28)
Dennis P. Orgill
Christine Park
Robert Demling
Hyaluronan-Based Membrane for the Prevention of Postsurgical Adhesions	307	(20)
James W. Burns
Kevin J. Barry
Index	327