Schizophrenia, 2nd Edition

by Editor: Steven R. Hirsch (Charing Cross and Westminster Medical School); Editor: Daniel R. Weinberger (MD)

• ISBN13: 9780632063888
• ISBN10: 0632063882
• Edition: 2nd
• Format: Hardcover
• Copyright: 2003-02-01
• Publisher: Wiley-Blackwell

Summary

Schizophrenia is one of the most complex and puzzling diseases to affect mankind. It is the most common of the severe mental illnesses (psychoses) with an estimated prevalence of 0.5 - 1% in the general population and accounts for a very large portion of the day to day workload of the average psychiatrist. 50% of long-term psychiatric patients in mental hospitals are schizophrenic.There is a great deal of controversy about the causes, diagnosis and treatment of schizophrenia with the consequence that a huge amount of research is carried out in the field by psychiatrists, psychologists, neuroscientists and pharmacologists. For the average practising psychiatrist seeing schizophrenics on a regular basis, making sense of the vast body of information on the subject and filtering out what is of clinical relevance can be very difficult. There is a constant stream of new drugs emerging and the newer generation of drugs (the so-called atypicals) is very effective, but often expensive.The Editors (one American and one British) are both highly respected clinical psychiatrists who are probably the leading experts on schizophrenia from their respective countries and jointly have published almost 150 papers on the subject. They have brought together a strong group of contributors from the USA, UK and Europe to produce what will be an essential reference for the trainee and practising psychiatrist.The book consists of four sections; descriptive aspects, causative aspects, physical treatments and psychological/behavioural/social treatments. There will be discussion of the theoretical controversies over symptomatology, classification and aetiology, the relationship of schizophrenia to the other psychoses, the significance of positive and negative symptoms and pre-morbid personality. There will be chapters on organic models of schiziophrenia, neurodevelopmental, genetic and structural studies and the role of high-expressed emotion. The final section will cover social and environmental treatment, the role of the families of schizophrenics and the psychoanalytical therapies. There is a new chapter on the patient's perspective written by a former patient.

Table of Contents

Contributors	vii
Foreword	xi
Nancy C. Andreasen
Preface to the Second Edition	xiii
Preface to the First Edition	xv
Part 1: Descriptive Aspects
Concepts and classification of schizophrenia	3	(12)
J.K. Wing
N. Agrawal
Descriptive psychopathology	15	(10)
J. Cutting
The symptoms of schizophrenia	25	(9)
R.L.M. Fuller
S.K. Schultz
N.C. Andreasen
Child and adolescent onset schizophrenia	34	(20)
C. Hollis
Atypical psychotic disorders	54	(14)
C.B. Pull
J.M. Cloos
N.V. Murthy
Late-onset schizophrenia	68	(12)
R. Howard
D.V. Jeste
The schizophrenia spectrum personality disorders	80	(21)
K. O'Flynn
J. Gruzelier
A. Bergman
L.J. Siever
Course and outcome of schizophrenia	101	(41)
H. Hafner
W. an der Heiden
Depression and schizophrenia	142	(26)
S.G. Siris
C. Bench
Neurocognitive deficits in schizophrenia	168	(19)
T.E. Goldberg
A. David
J.M. Gold
Part 2: Biological Aspects
The secondary schizophrenias	187	(16)
T.M. Hyde
S. W. Lewis
The epidemiological horizon	203	(29)
A. Jablensky
Risk factors for schizophrenia: from conception to birth	232	(19)
J.J. McGrath
R.M. Murray
Genetics and schizophrenia	251	(26)
B. Riley
P. Asherson
P. McGuffin
Intermediate phenotypes in genetic studies of schizophrenia	277	(21)
M.F. Egan
M. Leboyer
D.R. Weinberger
Electrophysiology	298	(12)
D.F. Salisbury
S. Krljes
R.W. McCarley
Neuropathology of schizophrenia	310	(16)
P.J. Harrison
D.A. Lewis
Schizophrenia as a neurodevelopmental disorder	326	(23)
D.R. Weinberger
S. Marenco
The neurochemistry of schizophrenia	349	(16)
B. Moghaddam
J.H. Krystal
Dopamine transmission in the schizophrenic brain	365	(23)
M. Laruelle
Animal models of schizophrenia	388	(15)
B.K. Lipska
D.R. Weinberger
Brain imaging in schizophrenia	403	(18)
P. Liddle
C. Pantelis
Part 3: Physical Treatments
The neuroscience and clinical psychopharmacology of first- and second-generation antipsychotic drugs	421	(21)
J.L. Waddington
S. Kapur
G.J. Remington
Acute pharmacological treatment of schizophrenia	442	(32)
S. Miyamoto
T.S. Stroup
G.E. Duncan
A. Aoba
J.A. Lieberman
Maintenance treatment	474	(15)
S.R. Marder
D.A. Wirshing
Treatment-resistant schizophrenia	489	(28)
T.R.E. Barnes
P. Buckley
S.C. Schulz
Electroconvulsive therapy and schizophrenia	517	(35)
H.A. Sackeim
Neuroleptic-induced acute extrapyramidal syndromes and tardive dyskinesia	552	(21)
V.S. Mattay
D.E. Casey
Non-neurological side-effects of antipsychotic drugs	573	(18)
D.C. Goff
R.I. Shader
Part 4: Psychosocial Aspects
Schizophrenia and violence	591	(22)
P.J. Taylor
S.E. Estroff
Schizophrenia and psychosocial stresses	613	(24)
P.E. Bebbington
E. Kuipers
Psychiatric rehabilitation	637	(20)
T.K.J. Craig
R.P. Liberman
M. Browne
M.J. Robertson
D. O'Flynn
Psychological treatments for schizophrenia	657	(31)
B.V. Martindale
K.T. Mueser
E. Kuipers
T. Sensky
L. Green
Mental health services	688	(13)
M. Muijen
F. Holloway
H. Goldman
Psychosis and recovery: some patients' perspectives	701	(12)
P. Chadwick
R. Lundin
G. Brown
A. McPartlin
C. Brookman
J. Antoniou
Economics of the treatment of schizophrenia	713	(12)
S.M. Essock
L.K. Frisman
N.H. Covell
Index	725