Schizophrenia from a Neurocognitive Perspective : Probing the Impenetrable Darkness

by Green, Michael Foster, Ph.D.

• ISBN13: 9780205184774
• ISBN10: 0205184774
• Edition: 1st
• Format: Hardcover
• Copyright: 1997-12-01
• Publisher: Prentice Hall

Summary

Schizophrenia From A Neurocognitive Perspective: Probing the Impenetrable Darkness is a sole-authored work and the first book to provide an integrative framework for the theme of neurocognition in schizophrenia. Recent advances in schizophrenia research have brought about a fundamental shift in the way the disorder is viewed. Schizophrenia is seen increasingly as a neurocognitive illness. This view has its roots in both the psychological and medical models, but it goes beyond them. The book uses neurocognitive concepts to guide the reader through neurochemical, neuroanatomical, and clinical features of schizophrenia. It also presents clinically relevant information on the interrelationships among neurocognitive deficits, treatment, and outcome. Both students and practitioners will benefit from learning about rapid advances in schizophrenia research and treatment that are dramatically changing our view of this disorder.

Table of Contents

Preface	xi
1 The Neurodevelopmental Model of Schizophrenia	1	(22)
A Big Shift	1	(1)
Epidemiological Studies	2	(4)
Neurohistological Studies	6	(2)
Archival-Observation Studies	8	(2)
Markers of Abnormal Neurodevelopment	10	(4)
Is There a Neurodevelopmental Subtype of Schizophrenia?	14	(3)
Implications for Neurocognition	17	(1)
References	18	(5)
2 Neurocognition and Schizophrenia: General Approaches and Specific Models	23	(18)
Early Formulations of Attentional Dysfunction in Schizophrenia	23	(4)
Clinical Neuropsychology and Differential Diagnosis	27	(4)
Experimental Psychology of Schizophrenia	31	(7)
References	38	(3)
3 The Scope of Neurocognitive Deficits in Schizophrenia	41	(20)
Types of Neurocognitive Deficits in Schizophrenia	41	(10)
Heterogeneity of Neurocognitive Deficits	51	(1)
Integrative Explanations	52	(5)
References	57	(4)
4 Neurocognitive Indicators of Vulnerability to Schizophrenia	61	(22)
Vulnerability Theory	63	(2)
Neurocognitive Deficits that Endure into Remission	65	(4)
Vulnerability in First-Degree Relatives	69	(1)
High-Risk Samples	70	(2)
Siblings and Parents of Schizophrenic Patients	72	(2)
Schizotypal Personality Disorder and Psychosis-Proneness	74	(2)
The Nature of Vulnerability to Schizophrenia	76	(1)
Contributions of Neurocognition to the Genetics of Schizophrenia	77	(3)
References	80	(3)
5 Symptoms and Neurocognition	83	(20)
Attempts to Link Neurocognition and Symptoms	86	(10)
When Neurocognitive Deficits Precede Symptomatology	96	(4)
References	100	(3)
6 Medications and Neurocognition	103	(18)
Development of Antipsychotic Medications	104	(3)
Conventional Neuroleptics and Neurocognition	107	(3)
Anticholinergic Medications and Neurocognition	110	(2)
New Antipsychotic Medications and Neurocognition	112	(6)
References	118	(3)
7 Neurocognition and Neuroimaging	121	(24)
Early Structural Neuroimaging	121	(3)
Modern Structural Neuroimaging	124	(5)
Functional Neuroimaging	129	(12)
References	141	(4)
8 Neurocognitive Correlated of Functional and Clinical Outcome	145	(18)
Neurocognition and Clinical Outcome	146	(3)
Neurocognition and Functional Outcome	149	(10)
A Change in Direction	159	(1)
References	160	(3)
9 Intervention for Neurocognitive Deficits	163	(20)
Neurocognitive Deficits and Cognitive Behavioral Interventions	165	(6)
Conceptual Challenges	171	(4)
Pharmacological Interventions for Neurocognitive Deficits	175	(1)
Functional Neuroimaging and Neurocognitive Interventions	176	(2)
Beyond the Symptoms of Schizophrenia	178	(1)
References	179	(4)
Index	183