Science in Medicine

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  • Edition: 1st
  • Format: Hardcover
  • Copyright: 2007-10-31
  • Publisher: Jones & Bartlett Learning

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This text is appropriate for graduate students, first and second year medical students, and allied health students, in courses throughout the curriculum of medicine and allied health, specifically courses that focus on metabolism and endocrinology.

Table of Contents

Pharmacological manipulation of cell death: clinical applications in sight?p. 2
Pharmacological manipulation of Bcl-2 family members to control cell deathp. 10
Caspases: Pharmacological manipulation of cell deathp. 18
IKK/NF-[kappa]B signaling: balancing life and death - a new approach to cancer therapyp. 26
Reawakening the cellular death program in neoplasia through the therapeutic blockade of IAP functionp. 34
The survival kinases Akt and Pim as potential pharmacological targetsp. 40
Mitochondria: pharmacological manipulation of cell deathp. 47
Death versus survival: functional interaction between the apoptotic and stress-inducible heat shock protein pathwaysp. 55
Autophagy in cell death: an innocent convict?p. 62
Endoplasmic reticulum stress: cell life and death decisionsp. 72
Dysregulation of Met receptor tyrosine kinase activity in invasive tumorsp. 82
Integrins in invasive growthp. 87
Stat proteins and oncogenesisp. 94
The cadherin-catenin adhesion system in signaling and cancerp. 98
Do tumor-suppressive mechanisms contribute to organism aging by inducing stem cell senescence?p. 102
When cells get stressed: an integrative view of cellular senescencep. 106
Telomeres, stem cells, senescence, and cancerp. 112
Bmi1, stem cells, and senescence regulationp. 120
Cellular senescence in cancer treatment: friend or foe?p. 125
Mechanisms for pituitary tumorigenesis: the plastic pituitaryp. 130
Melanoma genetics and the development of rational therapeuticsp. 144
Immunopathogenesis and therapy of cutaneous T cell lymphomap. 156
Cancer vaccines: progress reveals new complexitiesp. 171
IFNs and STATs in innate immunity to microorganismsp. 178
Molecular aspects of primary immunodeficiencies: lessons from cytokine and other signaling pathwaysp. 184
An integrated view of suppressor T cell subsets in immunoregulationp. 192
CD4[superscript +] Tregs and immune controlp. 203
Tregs and allergic diseasep. 212
Tregs and transplantation tolerancep. 221
C-reactive protein: a critical updatep. 227
New insights into atopic dermatitisp. 234
Recent insights into the immunopathogenesis of psoriasis provide new therapeutic opportunitiesp. 241
Exploiting dendritic cells to improve vaccine efficacyp. 253
The enigma of sepsisp. 262
Antimicrobial resistance: the example of Staphylococcus aureusp. 263
Bacterial infectious disease control by vaccine developmentp. 277
Development of an improved vaccine for anthraxp. 282
Helicobacter pyloripersistence: biology and diseasep. 286
The emergence of Lyme diseasep. 297
The application of biofilm science to the study and control of chronic bacterial infectionsp. 307
Quorum sensing in Staphylococcus infectionsp. 318
Quorum sensing and biofilm formation in Streptococcal infectionsp. 323
Pharmacological inhibition of quorum sensing for the treatment of chronic bacterial infectionsp. 329
Pseudomonas aeruginosa quorum sensing as a potential antimicrobial targetp. 337
Antimalarial drug resistancep. 342
Human African trypanosomiasis of the CNS: current issues and challengesp. 352
SARS coronavirus: a new challenge for prevention and therapyp. 362
Acute HIV revisited: new opportunities for treatment and preventionp. 366
Strategies for an HIV vaccinep. 375
Dengue: defining protective versus pathologic immunityp. 380
West Nile virus: a growing concern?p. 386
Progress on new vaccine strategies against chronic viral infectionsp. 392
Entry of parainfluenza virus into cells as a target for interrupting childhood respiratory diseasep. 405
Influenza vaccines: present and futurep. 416
Live-attenuated virus vaccines for respiratory syncytial and parainfluenza viruses: applications of reverse geneticsp. 420
Herpes simplex viruses: is a vaccine tenable?p. 426
Prophylactic human papillomavirus vaccinesp. 432
Disorders of lung matrix remodelingp. 440
New insights into the pathogenesis of asthmap. 449
JAK-STAT signaling in asthmap. 455
Rescuing protein conformation: prospects for pharmacological therapy in cystic fibrosisp. 460
Epithelial-mesenchymal transition and its implications for fibrosisp. 466
Oxygen, oxidative stress, hypoxia, and heart failurep. 476
NO/redox disequilibrium in the failing heart and cardiovascular systemp. 485
Genetic causes of human heart failurep. 494
Protein kinase cascades in the regulation of cardiac hypertrophyp. 503
Toward transcriptional therapies for the failing heart: chemical screens to modulate genesp. 514
Mitochondrial energy metabolism in heart failure: a question of balancep. 523
Death begets failure in the heartp. 532
Unchain my heart: the scientific foundations of cardiac repairp. 539
Biological basis for the cardiovascular consequences of COX-2 inhibition: therapeutic challenges and opportunitiesp. 551
Sex is a potent modifier of the cardiovascular systemp. 563
Cholesterol in health and diseasep. 568
Cholesterol, lipid rafts, and diseasep. 575
Malformation syndromes due to inborn errors of cholesterol synthesisp. 581
Intracellular cholesterol transportp. 589
Regulation and mechanisms of macrophage cholesterol effluxp. 596
Consequences of cellular cholesterol accumulation: basic concepts and physiological implicationsp. 601
Monogenic hypercholesterolemia: new insights in pathogenesis and treatmentp. 608
Isoprenoids as mediators of the biological effects of statinsp. 615
The channelopathies: novel insights into molecular and genetic mechanisms of human diseasep. 619
Mechanisms of sudden cardiac deathp. 623
Long QT syndrome: from channels to cardiac arrhythmiasp. 634
Genetics of acquired long QT syndromep. 641
Muscle channelopathies and critical points in functional and genetic studiesp. 649
Inherited disorders of voltage-gated sodium channelsp. 659
Cardiac and skeletal muscle disorders caused by mutations in the intracellular Ca[superscript 2+] release channelsp. 669
Chloride channel diseases resulting from impaired transepithelial transport or vesicular functionp. 675
Megakaryocyte biology and related disordersp. 684
The molecular mechanisms that control thrombopoiesisp. 691
Thrombus formation in vivop. 700
Platelet genomics and proteomics in human health and diseasep. 708
The biogenesis of platelets from megakaryocyte proplateletsp. 716
Platelets in inflammation and atherogenesisp. 723
Structure and function of the platelet integrin [alpha][subscript IIb][beta][subscript 3]p. 730
Minding the gaps to promote thrombus growth and stabilityp. 737
Untying the Gordian knot: policies, practices, and ethical issues related to banking of umbilical cord bloodp. 745
Intestinal ion transport and the pathophysiology of diarrheap. 752
Molecular mediators of hepatic steatosis and liver injuryp. 764
Liver fibrosisp. 770
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liverp. 780
Genetic epidemiology of diabetesp. 788
ATP-sensitive potassium channelopathies: focus on insulin secretionp. 797
Gestational diabetes mellitusp. 809
Regeneration of the pancreatic [beta] cellp. 816
Challenges facing islet transplantation for the treatment of type 1 diabetes mellitusp. 824
How does blood glucose control with insulin save lives in intensive care?p. 831
Thyrotropin receptor-associated diseases: from adenomata to Graves diseasep. 840
Inflammation, stress, and diabetesp. 852
Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndromep. 861
The role of cholesterol efflux in regulating the fertilization potential of mammalian spermatozoap. 870
Trophoblast differentiation during embryo implantation and formation of the maternal-fetal interfacep. 876
Acute renal failure: definitions, diagnosis, pathogenesis, and therapyp. 888
Kidney stone diseasep. 898
Salt handling and hypertensionp. 909
Pathogenesis of osteoporosis: concepts, conflicts, and prospectsp. 918
Paget disease of bonep. 926
Estrogen deficiency and bone loss: an inflammatory talep. 935
Regulation of bone mass by Wnt signalingp. 944
VEGF: A critical player in neurodegenerationp. 954
Neurogenesis and brain injury: managing a renewable source for repairp. 958
Oxidative stress, cell cycle, and neurodegenerationp. 963
Neuronal degeneration and mitochondrial dysfunctionp. 971
The role of cerebral amyloid [beta] accumulation in common forms of Alzheimer diseasep. 980
Alzheimer disease therapy: Can the amyloid cascade be halted?p. 989
Diagnosis and treatment of Parkinson disease: molecules to medicinep. 996
Huntingtin in health and diseasep. 1007
Programmed cell death in amyotrophic lateral sclerosisp. 1011
Multiple sclerosisp. 1019
Progress and problems in the biology, diagnostics, and therapeutics of prion diseasesp. 1027
The genetic epidemiology of neurodegenerative diseasep. 1035
Sodium channel mutations in epilepsy and other neurological disordersp. 1044
Finding schizophrenia genesp. 1052
The addicted human brain: insights from imaging studiesp. 1061
Mapping the new frontier - complex genetic disordersp. 1070
Mapping quantitative trait loci in humans: achievements and limitationsp. 1074
Linkage disequilibrium maps and association mappingp. 1080
Genetic counselors: translating genomic science into clinical practicep. 1086
Genetic counseling throughout the life cyclep. 1091
Payment of clinical research subjectsp. 1098
Embryonic death and the creation of human embryonic stem cellsp. 1105
Stem cells: science, policy, and ethicsp. 1108
Table of Contents provided by Blackwell. All Rights Reserved.

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