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9781603272803

Prostate Cancer Screening

by ; ;
  • ISBN13:

    9781603272803

  • ISBN10:

    1603272801

  • Edition: 2nd
  • Format: Hardcover
  • Copyright: 2009-03-10
  • Publisher: Humana Pr Inc

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Summary

More than one in six men will develop prostate cancer in their lifetime. In recent years there has been an explosion of information regarding PSA screening and biomarkers for the disease. In Prostate Cancer Screening, Second Edition, the world's leading experts on prostate cancer detection update the first edition with the latest findings. The book incorporates a series of thoughtful and cutting-edge works from the world's experts in prostate cancer screening, ranging from the current status quo of prostate cancer screening across the globe to consensus on optimal utilization of the traditional PSA and DRE tests, to cutting edge research in new biomarkers, biomeasures, and extended risk algorithms for prostate cancer. An additional chapter covers family-based linkage analysis as well as possible pitfalls in prostate cancer biomarker evaluation studies. Timely and authoritative, Prostate Cancer Screening, Second Edition, is an essential text for urologists, oncologists and family physicians, as well as researchers in the biomarker industry who seek methods to better develop and support markers and measures of prostate cancer. Book jacket.

Table of Contents

Prefacep. v
Contributorsp. xi
Color Platesp. xv
Trends in Prostate Cancer Screening
Overview of US Prostate Cancer Trends in the Era of PSA Screeningp. 3
Trends in Prostate Cancer Screening: Overview of the UKp. 15
Trends in Prostate Cancer Screening: Canadap. 23
Trends in Prostate Cancer Screening - Overview of Europep. 35
Prostate-Specific Antigen
Evolution of Prostate-Specific Antigen for Screeningp. 51
The Performance Characteristics of Prostate-Specific Antigen for Prostate Cancer Screeningp. 61
The Performance of PSA for Predicting Prostate Cancer After a Prior Negative Prostate Biopsyp. 71
Subfractions and Derivatives of Total Prostate-Specific Antigen in the Early Detection of Prostate Cancerp. 79
PSA Velocity at Presentation as a Predictor of Prostate Cancer Aggressivenessp. 97
Risk Assessment for Prostate Cancer
Nomograms for Prostate Cancerp. 117
Decision Aid Criteria and Artificial Neural Networks for Optimizing Prostate Cancer Risk Predictionp. 181
Development of the Prostate Cancer Prevention Trial Prostate Cancer Risk Calculatorp. 195
Integration of Risk Assessment in Prostate Cancer Screeningp. 205
Family History of Prostate Cancer During Rapidly Increasing Incidencep. 213
Recent Biomarkers for Prostate Cancer
PSA Isoforms: [-2]proPSA Significant Adjunct to Free PSAp. 225
PCA3
Transcriptional Profiling of Prostate Cancer: Biomarker Identification and Clinical Applicationsp. 243
Biomarkers for Prostate Cancer Detection: Family-Based Linkage Analysis and Case-Control Association Studiesp. 261
GSTPI Hypermethylation for Prostate Cancer Detectionp. 279
EPCA and EPCA-2 as Potential Biomarkers for Prostate Cancer Detectionp. 289
Design and Methodologic Considerations in Biomarker Studies
Toward a Robust System for Biomarker Triage and Validation - EDRN Experiencep. 297
Statistical Evaluation of Markers and Risk Tools for Prostate Cancer Classification and Predictionp. 307
Pitfalls in Prostate Cancer Biomarker Evaluation Studiesp. 319
Building upon Recently Completed and Ongoing Prospective Trials
Prostate-Specific Antigen and Its Role on the Prostate Cancer Prevention Trialp. 333
The Selenium and Vitamin E Cancer Prevention Trialp. 349
PLCO: A Randomized Controlled Screening Trial for Prostate, Lung, Colorectal, and Ovarian Cancerp. 361
The European Randomized Study of Screening for Prostate Cancer (ERSPC)p. 373
Indexp. 387
Table of Contents provided by Ingram. All Rights Reserved.

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