This volume represents the state-of-the-art of our understanding of aFGF and bFGF in the basal ganglia. Thus, the localisation of those growth factors, the control mechanisms of their expression, and their trophic actions are analysed in relation to nerve cell survival as well as to the neurodegenerative diseases affecting the basal ganglia. Some of the most advanced research on degenerative and regenerative features of the basal ganglia is also presented. These studies involve the actions of neurotrophins, epidermal growth factors, gangliosides and neuropeptides as well as their localisation and expression in the basal ganglia. These discoveries will help towards understanding the interactions between trophic factors and transmitters in the control of nerve function and their phenotypic maintenance; the studies in the work provide the appropriate background knowledge necessary to fully appreciate the impact of present FGF research on the trophic regulation of the basal ganglia.

Fibroblast Growth Factor-2, Ganglioside GM1 and the Trophic Regulation of the Basal Ganglia. Focus on the Nigrostriatal Dopamine Neurons	p. 1
DARPP-32/Protein Phosphatase-1/Na[superscript +]/K[superscript +] ATPase System: A Mechanism for Bidirectional Control of Cell Function	p. 43
Muscle-Derived Differentiation Factor and its Regulation of the Tyrosine Hydroxylase Gene in the Developing, Adult and Lesioned Rat Brain	p. 59
Glucocorticoid and Estrogen Effects on the Nigrostriatal and Mesolimbic Dopaminergic Systems	p. 67
Factors Associated to Dopaminergic Cell Death in Parkinson's Disease	p. 89
Compensatory Mechanisms at Dopamine D-2 Receptors	p. 101
Oxidative Stress and Reduced Receptor Responsiveness in Senescence	p. 111
Expression, Regulation and Receptor Distribution of Neurotrophins in the Mammalian Central Nervous System	p. 123
Localization of Neurotrophins and Their Receptors at the mRNA and Protein Level	p. 151
Effects of Brain-Derived Neurotrophic Factor on Injured Dopaminergic Neurons	p. 167
Fibroblast Growth Factors and Parkinson's Disease	p. 185
Homeobox Peptides as a Novel Class of Neurotrophic Molecules	p. 191
Growth Factors Involved in the Development, Maturation and Neuroplasticity of Midbrain Dopamine Neurons	p. 203
Ganglioside and Growth Factor Interactions Promote Mesencephalic Cell Survival from the Excitotoxic Actions of 2,4,5-Trihydroxyphenylalanine	p. 217
Trophic Factors and GM1 Ganglioside in the Basal Ganglia	p. 225
The Role of Gangliosides and Trophic Factors in Brain Repair	p. 235
Features of the Trophic Action of Polyamines	p. 251
Acidic and Basic Fibroblast Growth Factors are Present in, and Produce Effects upon, Mesencephalic Dopamine Neurons	p. 267
Presence of Interleukin-1 in the Central Nervous System	p. 285
Cellular Immediate-Early Genes in the Nervous System: Genes for All Reasons?	p. 301
Neuropeptide Synthesis in Astrocytes: Possible Trophic Roles	p. 317
Beta-Amyloid Precursor: A Neuronal and Glial-Derived Protein with Trophic-like Activities	p. 329
Neuron-Glia Interactions: Receptor Induced Events in Single Astroglial Cells and their Implications for Neuronal Excitability and for Neurotransmission	p. 345
Astrocytic Kynurenines as Modulators of Dopaminergic Function in the Rat Basal Ganglia	p. 365
Neurochemical and Behavioral Studies on L-dopa Toxicity in the Model of Manganese Lesioned Nigrostriatal Pathway in the Rat: Evidence for a Protective Effect of the GM[subscript 1] Lactone Siagoside	p. 381
The MPTP Model of Parkinson's Disease in the Mouse. Modafinil - a New Potential Neuroprotective Agent	p. 409
Recovery from MPTP-Induced Parkinsonism in Monkeys and Cats: Similar Mechanisms?	p. 425
The Evaluation of Antiparkinsonian Activities in Primate Models of Parkinsonism	p. 435
The 3-Acetylpyridine Model of Parkinsonism: Use of Cytochrome Oxidase Gene Expression as an Index of Alterations in Basal Ganglia Function	p. 443
Neuronal Plasticity: A Potential Role in Spiny Striatal Neuron Degeneration in Huntington's Disease	p. 465
Plasticity Responses After Neonatal Dopamine Lesions Induced With 6-Hydroxydopamine	p. 479
Compensatory Neurobiological Changes after Partial Lesions with 6-Hydroxydopamine	p. 503
Responses of Neostriatal Dopaminoceptive Cells to the Ischemic Insult	p. 517
Morphological and Functional Adaptation of Basal Ganglia Neurons after Cerebral Ischemia	p. 535
Clearance and Diffusion of Locally Applied Dopamine in Normal and 6-Hydroxydopamine-Lesioned Rat Striatum	p. 549
Target-Specific Outgrowth from Grafted Dopaminergic Neurons	p. 567
The Pharmacotherapy of Parkinson's Disease: Current Status and Future Opportunities	p. 581
Signal Transduction Mechanisms on Striatal Dopaminergic Neurons: Importance in Neurotrophism and Neuropathology	p. 595
Author Index	p. 609
Subject Index	p. 611
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