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9783764370800

Turning Up The Heat On Pain

by ;
  • ISBN13:

    9783764370800

  • ISBN10:

    3764370807

  • Format: Hardcover
  • Copyright: 2005-09-01
  • Publisher: Birkhauser

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Summary

Vanilloids mediate their effects by selective agonism of an ion channel, the vanilloid receptor 1 (TRPV1). TRPV1 is a ligand-gated, non-selective, cation channel preferentially expressed in small-diameter, primary afferent neurons, including nociceptive sensory nerves. In addition to be activated by capsaicin and related vanilloids, TRPV1 responds to heat and extracellular acidification, and will integrate simultaneous exposures to these stimuli. The aim of this book is to summarize recent insights in the role of TRPV1 in pain and inflammation, and to discuss how modulation of this receptor may lead to important advances in analgesic drug development. Insights into the prospects for the therapeutic potential of TRPV1 activation or inhibition, particularly in various painful or inflammatory conditions, are provided. The volume is written for basic scientists and clinicians interested in the mechanisms of pain, inflammation and the treatment of these conditions.

Table of Contents

List of contributors vii
Preface xi
Part I: Historical perspective on capsaicin and its receptor
János Szolcsányi
Hot peppers, pain and analgesics
3(22)
Part II: Molecular and cellular properties of vanilloid receptors
Makoto Tominaga
Structural determinants of TRPV1 functionality
25(14)
Janet Winter
TRPV1 distribution and regulation
39(16)
Part III: Pharmacology and physiology of vanilloid receptors
Peter M. Blumberg, Derek C. Braun, Noemi Kedei, Jozsef Lazar, Vladimir Pavlyukovets and Larry V. Pearce
Insights into TRPV1 pharmacology provided by non-capsaicin ligands
55(16)
Ruth A. Ross
Endocannabinoids and vanilloid TRPV1 receptors
71(24)
Zoltán Sándor and Arpad Szallasi
Vanilloid receptor-mediated hyperalgesia and desensitization
95(22)
Lars Arendt-Nielsen and Ole K. Andersen
Capsaicin in human experimental pain models of skin, muscle and visceral sensitization
117(30)
Part IV: Vanilloid receptor involvement in disease states
Peter Holzer
TRPV1 in gut function, abdominal pain and functional bowel disorders
147(20)
Maria G. Belvisi and Peter J. Barnes
TRPV1 in the airways
167(24)
Part V: Therapeutic potential of vanilloid agonists and antagonists
Keith R. Bley and Annika B. Malmberg
TRPV1 agonist-based therapies: mechanism of action and clinical prospects
191(20)
Francisco Cruz, Carlos Silva and Paulo Dinis
TRPV1 agonist therapies in bladder diseases
211(16)
Kenneth J. Valenzano, James D. Pomonis and Katharine Walker
TRPV1 antagonists and chronic pain
227(18)
Index 245

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