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9780195068177

New Perspectives on Genetic Markers and Diseases among Jewish People

by ;
  • ISBN13:

    9780195068177

  • ISBN10:

    0195068173

  • Format: Hardcover
  • Copyright: 1992-05-07
  • Publisher: Oxford University Press
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List Price: $80.00

Summary

This volume provides an authoritative, up-to-date account of the impact of molecular genetics on our understanding of genetic diseases prevalent among Jews. The extent of genetic variability among different Jewish communities is discussed in detail. After an introductory chapter on major demographic trends of world Jewry, the first part examines ethnohistorical relationships between different Jewish groups in light of nuclear and mictochondrial DNA polymorphisms. The next and largest section of the book reviews the most recent research on some 20 Mendelian disorders (among Ashkenz, Sephardi and Oriental Jews) and the implications of the astonishing molecular heterogeneity revealed in some of them. Advances in genetic aspects of common multifactorial diseases are covered in concluding chapters.

Table of Contents

History and Demography
Major Demographic Trends of World Jewry: The Last Hundred Years
Polymorphisms
Nuclear DNA Polymorphisms and Population Relationships
Y-Chromosome DNA Polymorphism in Ashkenazi and Sephardi Jews
Types of Mitochondrial DNA Among Jews
Variability and Population Genetics of G6PD
Genetic Diversity Among Jews Reexamined: Preliminary Analysis at the DNA Level
Mendelian DiseasesA. Diseases Present Mainly Among Ashkenazim
The Molecular Basis of Tay-Sachs Disease and Related GM2 Gangliosidoses Among Jews and Non-Jews
Molecular Genetics of Acid Sphingomyelinase and Niemann Pick Disease
Gaucher''s Disease
Bloom''s Syndrome XVII: The Consequences of Excessive Somatic Mutation
Biochemical and Enzyme Characterization of Canavan
Heterogenity of Factor XI Deficiency in Ashkenazi Jews
Nonclassical 21-Hydroxylase Deficiency
Molecular Genetics of 21-Hydroxylase Deficiency
Linkage Analysis in Familial Dysautonomia
Genetics of Idiopathic Torsion Dystonia in Ashkenazi Jews
Idiopathic Torsion Dystonia in Ashkenazi Jews: Autosomal Dominant Inheritance Pattern of Gene Located on Chromosome 9q32-34B. Diseasee Prevalent Mainly Among Non-Ashkenazim
Familial Mediterranean Fever: A Genetic Disorder Prevalent in Sephardi Jews
Diversity of Molecular Lesions Causing B-Thalassemia in Israeli Jewish Ethnic Groups
Molecular Analysis of Hyperphenylalaninenia in Israel: A Study of Jewish Genetic Diversity
Laron Type Dwarfism and Growth Hormone Gene Deletion
Tay-Sachs Disease Mutations Among Moroccan Jews
Benign Familial Neutropenia
Glanzmann Thrombasthenia in Israel: Clinical, Biochemical and Molecular Genetic Characterization
Classical and Non-Classical Congenital Adrenal Hyperplasia Among Non-Ashkenazi JewsC. Population Genetic Considerations
Lysosomal Storage Disorders Among Jews
Genetic Diseases in the Ashkenazi Population: Evolutionary Considerations
Whate Are Genes Like
That Doing in a Place Like This?
Human History and Molecular Prosopography
Carrier Testing for Lysosomal Diseases: Problems and Prospects
An Alternative Program for the Prevention of Tay-Sachs Disease
Cystic Fibrosis in Israel: Recent Progress in Molecular Studies
Advances in the Prenatal Diagnosis of B-Thalassemia in Israel
Development of Somatic Gene Therapy: A Simian Virus 40 Pseudoviral Vector for Hemopoietic Cells
Table of Contents provided by Publisher. All Rights Reserved.

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