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9780521112673

Machina Carnis: The Biochemistry of Muscular Contraction in its Historical Development

by
  • ISBN13:

    9780521112673

  • ISBN10:

    0521112672

  • Edition: 1st
  • Format: Paperback
  • Copyright: 2009-06-04
  • Publisher: Cambridge University Press

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Summary

Originally published in 1971, this is an account of the centuries of experiment and speculation that have led to our understanding of how muscles work. The book traces all the developments in the field since 1600 and devotes special attention to the breakthroughs made in the last century. It considers the nature of the muscle machine and its fuel, as well as the intricate regulation of energy supply under different conditions. It also examines the very varied kinds of muscle and the effects of some diseases on their structure and function. Finally it shows how the energy metabolism first elucidated for the mechanical work of muscle has been found to explain most of the other kinds of work done by cells, as in light production, secretion, ionic transport and electrical discharge. The biochemistry of muscle, carbohydrate metabolism and phosphorylations was the author's chosen field of research for over forty years.

Table of Contents

Preface
Bringing muscles into focus: the first two millennia
Muscle metabolism after the Chemical Revolution
the relationship between mechanical events, heat production and metabolism
The influence of brewing science on the study of muscle glycolysis
The discovery of phosphagen and adenosinetriphosphate
Adenosinetriphosphate as fuel and as phosphate-carrier
Early studies of msucle structure and theories of contraction
Interaction of actomyosin and ATP
Some theories of contraction mechanism
On myosin, actin and tropomyoson
The sliding mechanism
How does the sliding mechanism work?
Excitation, excitation-contraction coupling and relaxation
Happenings in intact muscle
Rigor and the chemical changes responsible for its onset
Respiration
Oxidative phosphorylation
The regulation of carbohydrate metabolism for energy supply to the muscle machine
A comparative study of the striated muscle of vertebrates
Enzymic and other effects of denervation, cross-innervation and repeated stimulation
some aspects of muscle disease
Contraction in muscles of invertebrates
Vertebrate smooth muscle
Energy provision and contactile proteins in non-muscular functions
References
Table of Contents provided by Publisher. All Rights Reserved.

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