The "gold standard" clinical reference on central nervous system infections is now in its thoroughly revised, updated Third Edition. More than 70 leading experts provide comprehensive, current information on all infections--both neural-specific and systemic--that involve the central nervous system. This edition includes new information on botulinum toxin as a biological weapon and a therapeutic agent, neurologic effects of viruses causing hemorrhagic fevers, and infections that have recently become more prevalent or been found in new geographic locations. The updated coverage of therapeutics includes AIDS/HIV medications and other antiviral drugs, new antifungal medications, and vaccinations against Lyme disease and bacterial meningitis.

Contributing Authors

xi

(4)

Preface to the First Edition

xv

(2)

Preface

xvii

(2)

Acknowledgments

xix

1 Introduction: Approach to the Patient with Central Nervous System Infection

1

(6)

David T. Durack

Richard J. Whitley

W. Michael Scheld

Part I: Viral Infections and Related Disorders

7

(290)

2 Pathogenesis and Pathophysiology of Viral Infections of the Central Nervous System

7

(16)

Kevin A. Cassady

Richard J. Whitley

3 Viral Meningitis and the Aseptic Meningitis Syndrome

23

(24)

Harley A. Rotbart

4 Measles

47

(10)

Diane E. Griffin

5 Poliomyelitis, Polio Vaccines, and the Post-Poliomyelitis Syndrome

57

(16)

John F. Modlin

David J. Coffey

6 Herpes Simplex Virus

73

(18)

Richard J. Whitley

7 Neurologic Manifestations of Varicella and Herpes Zoster

91

(16)

John W. Gnann, Jr.

Richard J. Whitley

8 Cytomegalovirus

107

(10)

Paul D. Griffiths

James E. McLaughlin

9 Epstein-Barr Virus

117

(12)

Jeffrey P. Ross

Jeffrey I. Cohen

10 Human Herpesvirus-6

129

(10)

Mary T. Caserta

Caroline Breese Hall

11 B Virus

139

(8)

Richard J. Whitley

12 Arthropod-Borne Encephalitides

147

(22)

Richard J. Whitley

13 Meningitis and Encephalitis Caused by Mumps Virus

169

(12)

John W. Gnann, Jr.

14 Rabies

181

(18)

Richard J. Whitley

15 Slow Viral Infections

199

(24)

David M. Asher

16 Perinatal Viral Infections

223

(32)

Richard J. Whitley

Sergio Stagno

17 Neurological Complications of AIDS

255

(18)

Joseph R. Berger

David M. Simpson

18 Guillain-Barre Syndrome

273

(24)

Holly G. Mussell

Alan K. Percy

John W. Benton

Part II: Bacterial and Mycoplasmal Infections

297

(318)

19 Pathogenesis and Pathophysiology of Bacterial Infections

297

(16)

Allan R. Tunkel

W. Michael Scheld

20 Neonatal Bacterial Meningitis

313

(22)

Arnold L. Smith

21 Acute Bacterial Meningitis in Children and Adults

335

(68)

Karen L. Roos

Allan R. Tunkel

W. Michael Scheld

22 Rickettsiae

403

(14)

Jerome H. Kim

David T. Durack

23 Tuberculosis

417

(28)

Abigail Zuger

Franklin D. Lowy

24 Infections Due to Nontuberculous Mycobacteria

445

(18)

J. Peter Cegielski

Richard J. Wallace, Jr.

25 Brain Abscess

463

(32)

Brian Wispelwey

Ralph G. Dacey, Jr.

W. Michael Scheld

26 Subdural Epyema

495

(12)

David C. Helfgott

Karen Weingarten

Barry J. Hartman

27 Epidural Abscess

507

(16)

Bruce G. Gellin

Karen Weingarten

Francis W. Gamache, Jr.

Barry J. Hartman

28 Complications of Infective Endocarditis

523

(32)

Patrick B. Francioli

29 Infections of Cerebrospinal Fluid Shunts

555

(24)

Bruce A. Kaufman

30 Whipple's Disease

579

(12)

David A. Relman

31 Bartonella Infections, Including Cat-Scratch Disease

591

(12)

Leonard N. Slater

David F. Welch

32 Mycoplasmal Diseases

603

(12)

Wallace A. Clyde, Jr.

Part III: CNS Syndromes Mediated by Bacterial Toxins

615

(54)

33 Botulism

615

(14)

James M. Hughes

Charles L. Hatheway

Stephen M. Ostroff

34 Tetanus

629

(26)

Thomas P. Bleck

Janete Salles Brauner

35 Bordetella pertussis

655

(14)

Erik L. Hewlett

Part IV: Spirochetal Infections

669

(52)

36 Syphilis

669

(16)

Edward W. Hook III

37 Lyme Disease

685

(36)

Louis Reik, Jr.

Part V: Fungal Infections

721

(44)

38 Fungal Meningitis

721

(20)

John R. Perfect

David T. Durack

39 Space-Occupying Fungal Lesions

741

(24)

Kent Sepkowitz

Donald Armstrong

Part VI: Protozoal and Helminthic Infections

765

(116)

40 Cerebral Malaria

765

(20)

J. Peter Cegielski

David A. Warrel

41 Toxoplasmosis

785

(22)

Carol S. Dukes

Benjamin J. Luft

David T. Durack

42 Trypanosomiasis

807

(24)

J. Peter Cegielski

David T. Durack

43 Amebic Infections

831

(14)

David T. Durack

44 Helminthic Infections

845

(36)

Miriam L. Cameron

David T. Durack

Part VII: Chronic Meningitis and Meningitis of Noninfective or Uncertain Etiology

881

(18)

45 Chronic Meningitis Syndrome and Meningitis of Noninfective or Uncertain Etiology

881

(18)

Barbara M. Gripshover

Jerrold J. Ellner

Part VIII: Diagnostic Evaluation and Neurosurgical Management

899

(84)

46 Cerebrospinal Fluid in CNS Infections

899

(24)

John E. Greenlee

Karen C. Carroll

47 Imaging of Intracranial Infections

923

(22)

Robert A. Zimmerman

Nadine J. Girard

48 Surgical Management of CNS Infections

945

(28)

Oren Sagher

Julian T. Hoff

49 Neurocritical Care of CNS Infections

973

(10)

Geoffrey S.F. Ling

Daniel F. Hanley

Part IX: Prevention

983

(58)

50 Vaccines for Viral Diseases with Significant CNS Manifestations

983

(30)

David W. Kimberlin

Stanley A. Plotkin

51 Vaccines Against Bacterial Meningitis

1013

(28)

Heikki Peltola

Subject Index

1041

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Infections of the Central Nervous System

9780397516964

0397516967

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