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9780470480137

Perinatal Stem Cells

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  • ISBN13:

    9780470480137

  • ISBN10:

    0470480130

  • Format: eBook
  • Copyright: 2010-01-01
  • Publisher: Wiley-Blackwell
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Summary

Discover how perinatal stem cells may prove to be a more powerful therapeutic tool than embryonic stem cellsNormally discarded as medical waste, perinatal stem cells are an incredible source of stem cells and are gaining phenomenal research attention for their potential to become a more powerful alternative to the controversial embryonic stem cells. In response to this growing field, this book provides a thorough tutorial on the current state of the art in perinatal stem cells.Presented by a panel of authorities whose expertise reaches from research to hematology to tissue engineering and beyond, this important volume covers all of the sources of stem cells found throughout pregnancy, revealing the underlying biology and potential therapeutic uses of each:Post-gestational maternal peripheral bloodUmbilical cord bloodWharton's jellyAmniotic fluidAmnion lining the amniotic cavityUmbilical veinChorionic mesenchymal stromal cellsMulti-potent cellsPlacenta stem cellsThis book is a bountiful source for researchers, graduate students, cell biologists, gene therapists, obstetricians and gynecologists, and professionals engaged in regenerative medicine and developmental biology.

Table of Contents

Preface
Contributors
Introduction: Perinatal Stem Cells
Cord Blood Transplants: Perinatal Stem Cells in Clinical Practice
Introduction
Hematopoietic Stem Cell Transplants: Adult Donor Collection
Hematopoietic Stem Cell Transplants: Adult Donor Testing
Hematopoietic Stem Cell Transplants: Recipient Issues
Collection and Processing of Cord Blood Units
Bone Marrow versus Single Cord Blood: Pediatric
Bone Marrow versus Cord Blood: Adults
Cord Blood Transplant: Advantages and Disadvantages
Double Cord Blood Transplants: Ablative Regimens
Double Cord Blood Transplant: Non-Myeloablative Regimens
Chimerism
Predicting the Winner
Are Two Cords Better Than One?
Other Experimental Strategies
Summary
References
Expanding the Therapeutic Potential of Umbilical Cord Blood Hematopoietic Stem Cells
Introduction: Hematopoietic Stem Cells, the Therapeutic Distributed Stem Cells in Umbilical Cord Blood
Biological Barriers to Hematopoietic Stem Cell Therapy
Umbilical Cord Blood: An Ideal Source of Therapeutic Hematopoietic Stem Cells
Shortcomings of Ex Vivo HSC Expansion Strategies
A Novel Strategy With Potential to Enable Ex Vivo Expansion of Umbilical Cord Blood Hematopoietic Stem Cells
Acknowledgments
References
Use of Fetal Cells in Regenerative Medicine
Introduction
Principles of Tissue Engineering
Cell Sources for Tissue Engineering
Examples of Possible Use and Implications of Perinatal Stem Cells
Placental Derived Stem Cells (Chorionic, Amniotic Membranes)
Amniotic Derived Stem Cells (hAMSC/Placental!)
Amniotic Fluid-Derived Stem Cells (Nonplacental!)
Conclusion
References
Perinatal Stem Cell Therapy
The Fetus as Recipient for Pre- and Perinatal Stem Cell Transplantation
Prenatal Cell Transplantation: Current Experience
How Do We Improve the Success of Prenatal Stem Cell Transplantation?
Mesenchymal Stem Cells for Prenatal Transplantation
Fetal Gene Therapy as a New Strategy
Current Issues of Postnatal Gene Therapy
Prenatal Gene Therapy
Animal Models of Prenatal Gene Therapy
Fetal Gene Therapy Targeting Hematopoietic Stem Cells
Safety Aspects of Prenatal Gene Therapy
Ethical Considerations
References
Umbilical Cord Mesenchymal Stem Cells
Preparation and Culture of UC-MSC
Characteristics-Properties and Bone Marrow Comparison
UC-MSC as Feeder Layer for Expansion of Human Cells
Clinical Indications for UC-MSC
References
Wharton's Jelly-Derived Mesenchymal Stromal Cells
Mesenchymal Stromal Cells
Immunophenotype of Mesenchymal Stromal Cells
MSCs are Multipotent Cells
MSC and Stromal Support of the Stem Cell Niche
Defining Primitive Stromal Cells: Differences between Fetal and Adult MSCs
Umbilical Cord MSCs
Characterization of Wharton's Jelly Derived Cells
Other MSC-Like Cells from Umbilical Cord
Comparison of WJCs to Adult Derived MSCs
In Vitro Differentiation of WJCs
Comparison of WJCs to Fetal MSCs
Transplantation of WJCs
WJCs as Primitive Stromal Cells
Summary
Acknowledgments
References
Perinatal Endothelial Progenitor Cells
The Role of Vascular Stem Cells in Postnatal Blood Vessel Formation: Endothelial Progenitor Cells and Postnatal Vasculogenesis
Sources of Endothelial Progenitor Cells
EPCs, Vasculogenesis and Angiogenesis
EPCs and Tissue Engineering
EPCs and Cardiovascular Tissue Engineering
The Future: Vascularized Engineered Tissue
References
Umbilical Cord Derived Mast Cells as Models For the Study of Inflammatory Diseases
Introduction
Mast Cell Triggers
Mast Cell Mediators
Selective Release of Mast Cell Mediators
Natural Mast Cell Secretion Inhibitors
Mast-T Cell Interaction
Inflammatory Skin Diseases
Fibromyalgia Syndrome
Asthma
Inflammatory Arthritis
Coronary Inflammation
Ocular Hypersensitivity Reactions
Conclusion
References
Amniotic Fluid Derived Stem Cells
Introduction
Amniotic Fluid Cells
The Discovery of Stem Cells in Amniotic Fluid
Cultivation of Amniotic Fluid Derived Stem Cells
Characteristics of Amniotic Fluid Derived Stem Cells
Differentiation Potential of Amniotic Fluid Stem Cells
Amniotic Fluid as a Promising Alternative Source for Neural Stem Cells
Current Applications of Amniotic Fluid Stem Cells in Therapy
Amniotic Fluid Stem Cells Banking
References
Amniotic Epithelial Stem Cells in Regenerative Medicine
Introduction
Amnion and Its Properties
Isolation and Culture of hAE Cells
Stem Cell Characteristics of Amniotic Epithelium-Derived Cells
Differentiation of hAE Cells
Future Directions
Conclusions
Acknowledgment
References
Human Umbilical Vein Endothelial Cells and Human Dermal Microvascular Endothelial Cells Offer New Insights into the Relationship Between Lipid Metabolism, Angiogenesis, and Abdominal Aortic Aneurysm
Human Umbilical Vein Endothelial Cells
Role of Angiogenesis in the Pathophysiology of Disease
HMG-CoA Reductase Inhibitors have Therapeutic Effects that are Both Dependent and Independent of Cholesterol Lowering
Studies of the Effects of Statins on Angiogenesis Using Both In Vivo Models and In Vitro HUVEC and HDMEC Models for Angiogenesis
References
Hematopoietic Stem Cell Development in the Placenta
Introduction
The Hematopoietic System
Historical Perspective on Placental Hematopoiesis
Development and Structure of the Mouse Placenta
Hematopoietic Activity in the Mouse Placenta
Phenotype of Placental HSCs
Origin and Localization of Placental HSCs
Summary and Future Directions
References
Fetal Cell Microchimerism, a Low-Grade Naturally Occurring Celltherapy
Introduction
The Placenta is a Source of Stem Cells
Transfer of Fetal Progenitor Cells During Gestation
Fetal Progenitor Cells in Maternal Tissues
Future Therapies
References
Index
Table of Contents provided by Publisher. All Rights Reserved.

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