In the post-genomic world, advances in the comprehension of cell behaviour will depend upon scientists deciphering the molecular basis of interactions between proteins and membranes. Bringing together contributions from chemists, biologists and physicists, Biophysical Chemistry: Membranes and Proteins demonstrates how multidisciplinary teams can gain insights into understanding complex biological systems. This book reflects both the scope and the interdisciplinary nature of the field, with topics including: modelling of biological systems; membrane structure and interactions; probing biomolecules; and channels and receptors. Full of stimulating articles and opinions, readers from academia and industry will welcome the wide range of coverage and the state-of-the-art science.

I Probing Biological Molecules: Theory and Experiment

Flow Oriented Linear Dichroism to Probe Protein Orientation in Membrane Environments

3

(17)

A. Rodger

J. Rajendra

R. Mortimer

T. Andrews

J.D. Hirst

A.T.B. Gilbert

R. Marrington

T.R. Dafforn

D.J. Halsall

M. Ardhammar

B. Norden

C.A. Woolhead

C. Robinson

T.J.T. Pinheiro

J. Kazlauskaite

M. Seymour

N. Perez

M.J. Hannon

Quantitative Protein Circular Dichroism Calculations

20

(11)

N.A. Besley

J.D. Hirst

Probing Cellular Structure and Function by Atomic Force Microscopy

31

(19)

M.A. Horton

P.P. Lehenkari

G.T. Charras

Physical Characterization of Wild Type and mnn9 Mutant Cells of Saccharomyces cerevisiae by Atomic Force Microscopy (AFM)

50

(8)

A. Mendez-Vilas

I. Corbacho

M.L. Gonzalez-Martin

M.J. Nuevo

Probing Supramolecular Organisation at Immune Synapses

58

(14)

F.E. McCann

K. Suhling

L.M. Carlin

K. Eleme

K. Yanagi

P.M.W. French

D. Phillips

D.M. Davis

Probing the Structure of Viral Ion Channel Proteins: A Computational Approach

72

(6)

W.B. Fischer

M.S.P. Sansom

The Impact of H2O2 on the Structure of Catalases by Molecular Modelling Methods

78

(7)

S.G. Kalko

J.LI. Gelpi

M. Orozco

Entropy in the Alignment and Dimerization of Class C G-Protein Coupled Receptors

85

(9)

M.K. Dean

C. Higgs

R.E. Smith

P.D. Scott

R.P. Bywater

T.J. Howe

C.A. Reynolds

Electrostatic Stability of Wild Type and Mutant Transthyretin Oligomers

94

(9)

S. Skoulakis

J.M. Goodfellow

Simulations of Human Lysozyme: Conformations Triggering Amyloidosis in 156T Mutant

103

(15)

G. Moraitakis

J.M. Goodfellow

Collective Excitation Dynamics in Molecular Aggregates: Exction Relaxation, Self-Trapping and Polaron Formation

118

(18)

M. Dahlbom

W. Beenken

V. Sundstrom

T. Pullerits

Surprising Electro-magnetic Properties of Close Packed Organized Organic Layers -- Magnetization of Chiral Monolayers of Polypeptide

136

(11)

I. Carmeli

V. Shakalova

R. Naaman

Z. Vager

Barrier Crossing by a Flexible Long Chain Molecule -- The Kink Mechanism

147

(16)

K.L. Sebastian

II Proteins, Lipids and Their Interactions

Lipid Interaction with Cytidylyltransferase Regulates Membrane Synthesis

163

(14)

S. Jackowski

I. Baburina

Models and Measurements on the Monolayer Bending Energy of Inverse Lyotropic Mesophases

177

(14)

A.M. Squires

J.M. Seddon

R.H. Templer

Hemolytic and Antibacterial Activities of LK Peptides of Various Topologies: A Monolayer and PM-IRRAS Approach

191

(8)

S. Castano

B. Desbat

H. Wroblewski

J. Dufourcq

A Novel Approach for Probing Protein--Lipid Interactions of MscL, a Membrane-Tension-Gated Channel

199

(9)

P.C. Moe

P. Blount

Folding of The α-Helical Membrane Proteins DsbB and NhaA

208

(7)

D.E. Otzen

FhuA, an Escherichia coli Transporter and Phage Receptor

215

(6)

P. Boulanger

L. Plancon

M. Bonhivers

L. Letellier

Morpholgical Aspects of in cubo Protein Crystallisation

221

(16)

C. Sennoga

B. Hankamer

A. Heron

J.M. Seddon

J. Barber

R.H. Templer

Mobility of Proteins and Lipids in the Photosynthetic Membranes of Cyanobacteria

237

(6)

C.W. Mullineaux

M. Sarcina

Partitioning and Thermodynamics of Chlordiazepoxide in n-Octanol/Buffer and Liposome System

243

(5)

C. Rodrigues

P. Gameiro

S. Reis

J.L.F.C. Lima

B. De Castro

Distribution of Vitamin E in Model Membranes

248

(6)

P.J. Quinn

Theory on Opening-up of Liposomal Membranes by Adsorption of Talin

254

(13)

Y. Suezaki

Differential Scanning Calorimetry and X-Ray Diffraction Studies of Glycolipid Membranes

267

(10)

O. Ces

J.M. Seddon

R.H. Templer

D.A. Mannock

R.N. McElhaney

Subject Index

277

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