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9780195061062

DNA Topoisomerases in Cancer

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  • ISBN13:

    9780195061062

  • ISBN10:

    0195061063

  • Format: Hardcover
  • Copyright: 1991-08-22
  • Publisher: Oxford University Press
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List Price: $84.80

Summary

DNA Topoisomerases are a unique class of enzymes that are responsible for the control and modification of DNA topology (tertiary structure); one example of their function is the transformation of chromosomes from a supercoiled condensed state to uncoiled strands and vice versa. They are of interest both for their intrinsic role in cell biology (i.e. control of cell division) and also because some anticancer drugs, such as camptothecin, act by inhibiting their action.

Table of Contents

Genetics and Biology of DNA Topoisomerases
Genetic and Biochemical Studies of Eukaryotic DNA Topoisomerases - From Yeast to Man
DNA Topoisomerases and Antitumor Drugs
DNA Topoisomerase Genes
The Influence of Camptothecin on Topoisomerase I Interaction with Genomic Sequences
Inhibitors of Topoisomerase I
Chemistry and Antitumor Activity of Camptothecins
Structure-Activity Relationship of Camptothecins
Cellular Regulation and Chromatin Localization of Topoisomerase I Action
Evidence for Topoisomerase Heterogeneity: Implications for the Discovery of Novel Antitumor Drugs
Biochemistry of Camptothecin - Topoisomerase I Interaction
Inhibitors of Topoisomerase II
A Unifying Model for Topoisomerase Inhibition by Epipodophyllotoxins and Intercalating Agents
Effect of Etoposide on Topoisomerase II -- Mediated Reactions: Analysis of Drug Action
Role of the T4 Topoisomerase in Sensitivity and Resistance to m-AMSA
Models of DNA Recombination: Potyential Role of Topoisomerases
Drug Resistance and Topoisomerase II
Reconstitution of Topoisomerase II - Mediated Drug Sensitivity in Somatic Cell Hybrids
"Atypical" Multi-Drug Resistance
Utility of Topoisomerase Inhibitors in Clinical Oncology
Layers of Drug Resistance in Cancer: Is Topoisomerase II One of Them?
Table of Contents provided by Publisher. All Rights Reserved.

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