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Written and edited by world's leading authorities, the new edition of this leading textbook features new chapters covering the very latest developments in extrahepatic manifestations and new anti-viral treatments for HBV and HCV. With individual sections on each strain of hepatitis, the text offers a level of detail unmatched by any other reference.
Contributors, vii
Preface, xii
Section I: Introduction to Liver Biology
1 Liver regeneration and fibrosis, 3Stuart J. Forbes and Malcolm R. Alison
2 Hepatic immunology, 13Gyongyi Szabo and Johanna Bruneau
Section II: Hepatitis A Virus
3 Structure, molecular virology, natural history, and experimental models, 29Gerardo Kaplan, Krishnamurthy Konduru, Mohanraj Manangeeswaran, Jerome Jacques, Nadia Amharref, and Siham Nakamura
4 Epidemiology and prevention, 43Benjamin Cowie and Stephen A. Locarnini
Section III: Hepatitis B Virus and Other Hepadnaviridae
5 Structure and molecular virology, 65Souphalone Luangsay and Fabien Zoulim
6 Epidemiology and prevention, 81Philip R. Spradling, Dale J. Hu, and Brian J. McMahon
7 Other Hepadnaviridae (including Avihepadnaviridae and woodchuck hepatitis viruses), 96Stephen A. Locarnini and Michael Roggendorf
8 Molecular variants of hepatitis B surface antigen (HBsAg), 107Seyed Mohammad Jazayeri, Seyed Moayed Alavian, Payam Dindoost, Howard C. Thomas, and Peter Karayiannis
9 Molecular variants of the precore, core, and core promoter regions of hepatitis B virus, and their clinical significance, 127Peter Karayiannis, William F. Carman, and Howard C. Thomas
10 Natural history of chronic hepatitis B virus infection, 143Yun-Fan Liaw
11 Extrahepatic manifestations of hepatitis B infection, 154Christian Trépo, Majid Amiri, and Loïc Guillevin
12 Hepatocellular carcinoma: Molecular aspects in hepatitis B, 163Marie Annick Buendia and Pierre Tiollais
13 Murine models and human studies of pathogenesis of chronic hepatitis B, 176Juandy Jo, Anthony Tanoto Tan, and Antonio Bertoletti
14 Treatment of hepatitis B, 188Hellan K. Kwon and Annfca S.F. Lok
15 Liver transplantation for chronic hepatitis B and C, 203Ed Gane
Section IV: Hepatitis C Virus
16 Structure and molecular virology, 221Michael J. McGarvey and Michael Houghton
17 Epidemiology and prevention, 246Josep Quer and Juan I. Esteban Mur
18 The immune response to HCV in acute and chronic infection, 266Robert Thimme and Salim I. Khakoo
19 Animal models of hepatitis C virus infection, 280Patrizia Farci and Jens Bukh
20 Extrahepatic manifestations of hepatitis C virus infection, 295Benjamin Maasoumy, Michael P. Manns, and Markus Cornberg
21 Central nervous system complications of hepatitis C virus infection, 310Daniel M. Forton, Simon Taylor-Robinson, Markus Gess, and Howard C. Thomas22 In vitro replication models, 325Volker Lohmann, Sandra Bühler, and Ralf Bartenschlager
23 Natural history of chronic HCV infection and non-invasive assessment of hepatic fibrosis, 341Laurent Castera
24 Hepatitis C and hepatocellular carcinoma, 353Hubert E. Blum
25 Treatment of hepatitis C, 362Christoph Welsch and Stefan Zeuzem Thomas—Viral Hepatitis
26 Development of anti-HCV drugs, 377Esperance Schaefer and Raymond T. Chung
Section V: Hepatitis D Virus
27 Structure and molecular virology, 395Francesco Negro
28 Epidemiology and natural history, 403Heiner Wedemeyer, Svenja Hardtke, and Michael P. Manns
29 Treatment of hepatitis D, 410Alessia Ciancio and Mario Rizzetto
Section VI: Hepatitis E Virus
30 Structure and molecular virology, 419Xiang-Jin Meng
31 Epidemiology, experimental models, and prevention: zoonotic aspects of hepatitis E, 431Subrat Kumar Panda and Satya Pavan Kumar Varma
32 Clinical and pathological features, and diagnosis, 442Cyril Sieberhagen and Matthew E. Cramp
Section VII: Clinical Aspects of Viral Liver Disease33 Clinical and diagnostic aspects of viral hepatitis, 453Cui Li Lin, Chelsea Q. Xu, and Jack R. Wands
34 Treatment of acute hepatitis, severe acute hepatitis, and acute liver failure, 468Hans L. Tillmann and Alastair D. Smith
35 Hepatitis and hemophilia, 486Mike Makris and Geoffrey Dusheiko
36 Hepatitis in persons infected with HIV, 494Janice Main and Brendan McCarron
37 Migration, hepatitis B, and hepatitis C, 506Manuel Carballo, Rowan Cody, and Megan Kelly
38 Occupational aspects of hepatitis, 515William L. Irving and Fortune Ncube
39 Neonatal and pediatric infection, 529Deirdre A. Kelly and C.Y. William Tong
40 Management of hepatocellular carcinoma, 544Massimo Iavarone and Massimo Colombo
41 Application of molecular biology to the diagnosis of viral hepatitis, 552Stéphane Chevaliez, Christophe Rodriguez, and Jean-Michel Pawlotsky
42 Disinfection and sterilization, 564Martin S. Favero and Walter W. Bond
43 Evolution of hepatitis viruses, 575Peter Simmonds and Donald B. Smith
Index, 587
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