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9780471969976

Coumarins Biology, Applications and Mode of Action

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  • ISBN13:

    9780471969976

  • ISBN10:

    0471969974

  • Edition: 1st
  • Format: Hardcover
  • Copyright: 1997-04-21
  • Publisher: Wiley
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Summary

Coumarins: Biology, Applications and Mode of Action predominantly focuses on the parent compound, coumarin, and its main metabolite in humans, 7-hydroxycoumarin. It describes in detail every facet of these compounds including history, toxicology, chemistry, metabolism, analysis, clinical, veterinary and other applications, their roles as immunomodulatory agents and speculates on their mode of action.

Author Biography

Richard O'Kennedy is the editor of Coumarins: Biology, Applications and Mode of Action, published by Wiley.

R. Douglas Thornes is the editor of Coumarins: Biology, Applications and Mode of Action, published by Wiley.

Table of Contents

List of Contributors vii(2)
Preface ix
1. History of the Development and Applications of Coumarin and Coumarin-related Compounds
22(1)
Inge Weinmann
2. The Chemistry and Occurrence of Coumarins
23(44)
Gary J. Keating
Richard O'Kennedy
3. The Metabolism of Coumarin
67(26)
Olavi Pelkonen
Hannu Raunio
Arja Rautio
Markku Pasanen
Matti A. Lang
4. The Effects of Coumarin and its Metabolites on Cell Growth and Development
93(10)
Barbara Seliger
5. Coumarin as an Immunomodulator
103(22)
Gerhard J. Zlabinger
6. The Mode of Entry of Coumarin into Cells and its Effects on Cell-Cell Communication and Migration
125(18)
Kurt S. Zanker
7. Coumarin in the Treatment of Lymphoedema and Other High-Protein Oedemas
143(42)
John R. Casley-Smith
Judith R. Casley-Smith
8. Mode of Action of Coumarin in the Treatment of Thermal Injuries
185(24)
Neil B. Piller
9. Renal Cell Carcinoma: The Background, Rationale and Current Development of Coumarin (1,2-benzopyrone) as a Potential Therapeutic Agent
209(32)
Scot W. Ebbinghaus
James L. Mohler
M. Ernest Marshall
10. The Potential Role of Coumarins in the Therapy of Prostate Cancer
241(14)
James L. Mohler
Bernadette T. Williams
John A. Freeman
M. Ernest Marshall
11. Clinical and Biological Observations Associated with Coumarins
255(12)
R.D. Thornes
12. Analysis of Coumarins
267(36)
Declan P. Bogan
Gary J. Keating
Heiko Reinartz
Ciaran F. Duffy
Malcolm R. Smyth
Richard Kennedy
13. Coumarins--Multifaceted Molecules with Many Analytical and Other Applications
303(30)
Deirdre Cooke
Brian Fitzpatrick
Richard O'Kennedy
Teresa McCormack
Denise Egan
14. Suggested Modes of Action of Coumarins and Some Comments on their Significance
333(4)
Richard O'Kennedy
R.D. Thornes
Index 337

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