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9783527347285

Long-lived Proteins in Human Aging and Disease

by
  • ISBN13:

    9783527347285

  • ISBN10:

    3527347283

  • Edition: 1st
  • Format: Hardcover
  • Copyright: 2021-04-19
  • Publisher: Wiley-VCH

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Summary

This authoritative overview on an emerging topic in the molecular life sciences covers all aspects of the aging of (long-lived) proteins. It describes the molecular mechanisms of aging on the protein level, in particular the most common side chain modifications and includes analytical methods to study protein half-life and the accumulation of modifications. Finally, the impact of protein aging on several age-related disases in humans is dissected, and their role in limiting human lifespan is discussed.

Author Biography

Roger Truscott is a Research Professor at the Illawarra Health and Medical Research Institute, University of Wollongong. Having obtained his PhD at Melbourne University, he has spent most of his academic career working for the University of Sydney and the University of Wollongong. He has authored over 200 scientific publications. His main field of research is human aging with particular reference to age-related diseases, such as cataract. He has received numerous awards including a senior NHMRC fellowship and the National Foundation for Eye Research (USA) Cataract Research Award.

Table of Contents

Modification of long-lived-proteins (LLPs) and protein insolubility
Chaperones as agents that detect and bind to modified LLPs
Old proteins as provokers of immune response
LLPs in synaptosomes and their role in memory processes
Methods for detecting aging proteins
Mass spectrometry methods for the detection of LLPs
Proteolipid protein in myelin and multiple sclerosis
Cellular processing of protein complexes
Remarkable stability of protein succinimides
Imaging methodologies to visualize LLPs
LLPs in Alzheimer's and dementia
General protein racemization
Post-transcriptional modifications of LLPs
LLPs within the context of mechanisms of cellular aging
Human Aging and LLPs
PIMT (Protein isoAsp methyl transferase) in the retina
Modified LLPs in cancer

Supplemental Materials

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The New copy of this book will include any supplemental materials advertised. Please check the title of the book to determine if it should include any access cards, study guides, lab manuals, CDs, etc.

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