The Spectrum of Neuro-AIDS Disorders

"In the decade-plus since the introduction of highly active antiretroviral therapy (HAART), clinicians and researchers have come to recognize the implications of the brain as a reservoir for resistant HIV, and the significance of this chronic infection to the patient's functioning and prognosis. This unique volume covers the full scope of research on the neurological and neurobehavioral implications of HIV/AIDS, or "neuro-AIDS," including the fields of microbiology and immunology." "In this book, noted researchers from all over the world examine the wide range of HIV-associated neurological and neurobehavioral disorders. Neuro-AIDS can affect the entire neuraxis, resulting in physiological, neurological, and neurobehavioral deficits ranging from distal sensory polyneuropathy and primary CNS lymphoma to HIV-associated neurocognitive impairment and disorders including HIV-associated dementia. Toxicities of the antiretroviral medications themselves are a serious concern." "This book presents the wide variety of HIV-associated disorders and comorbidities with a look at the pre-HAART literature as well as the latest findings from the post-HAART era. Pathophysiology and selected neuroimaging techniques for diagnosis and assessment are examined in detail. In addition, this volume stands out for its chapters on specific patient populations such as women, children, minorities, and older persons, as well as special chapters addressing medico-legal and end-of-life concerns. The book concludes with a look at global issues and the future of neuro-AIDS in the HAART era."--BOOK JACKET.