Foreword | p. xi |
Preface | p. xiii |
Acknowledgments | p. xvi |
Function and Dysfunction of Opioid Receptors | |
Targeting of Opioid Receptors to Presynaptic Sites | p. 1 |
Function and Dysfunction of Opioid Receptors in the Spinal Cord | p. 17 |
Opioid Receptors in the Periphery | p. 45 |
Relevance of Proposed Mechanisms of G-Protein-Coupled Receptor Desensitization to Opioid Receptors | p. 59 |
Modulation of Opioid Analgesia: Tolerance and Beyond | p. 83 |
Clinical Pharmacology of Opioids--Relevant Aspects | |
Different Opioids--Same Actions? | p. 97 |
Route of Opioid Administration--Does It Make a Difference? | p. 117 |
Clinical Status of Opioid Tolerance in Long-Term Therapy of Chronic Noncancer Pain | p. 129 |
Understanding and Improving Opioid Sensitivity--New Perspectives | |
Phenotypic Changes Induced in Dorsal Root Ganglion Neurons by Nerve Injury | p. 145 |
Opioid Analgesic Activity in Neuropathic Pain States | p. 163 |
Opioid Sensitivity in Experimental Central Pain after Spinal Cord Injury in Rats | p. 183 |
Antinociceptive Effect of Opioid Substances in Different Models of Inflammatory Pain | p. 201 |
Opioid Modulation of Visceral Pain | p. 225 |
Opioid Sensitivity in Antinociception: Role of Anti-Opioid Systems with Emphasis on Cholecystokinin and NMDA Receptors | p. 237 |
Alpha, Omega, and In Between | p. 253 |
Alternatives to Mu-Opioid Analgesics: Delta-Opioid- and Galanin-Receptor-Selective Compounds | p. 269 |
Opioid Gene Knockouts: New Answers to Old Questions? | p. 281 |
Opioid Sensitivity of Different Chronic Pain States--Answers and Questions from the Clinic | |
The Debate over Opioids and Neuropathic Pain | p. 307 |
Opioids and Painful Peripheral Neuropathy | p. 319 |
Efficacy of Peripheral Opioid Analgesia in Inflammatory Pain: Evidence from Clinical Studies | p. 327 |
Opioids in Ischemic Pain | p. 337 |
Opioids for Chronic Musculoskeletal Pain | p. 349 |
Opioids in Headache | p. 367 |
How Should We Measure the Outcome? | p. 371 |
Index | p. 385 |
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