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9780931092282

Opioid Sensitivity of Chronic Noncancer Pain

by ; ;
  • ISBN13:

    9780931092282

  • ISBN10:

    0931092280

  • Edition: 1st
  • Format: Hardcover
  • Copyright: 1999-07-01
  • Publisher: Lippincott Williams & Wilkins
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List Price: $42.00

Author Biography

Pawel Alster, PhD: Department of Medical Laboratory Sciences and Technology, Division of Clinical Neurophysiology, Karolinska Institute, Huddinge University Hospital, Sweden Flemming Bach, MD, PhD: Department of Neurology and Danish Pain Research Center, Aarhus University Hospital, Denmark Gary J. Bennett, PhD: Department of Neurology, MCP Hahnemann University, Philadelphia, Pennsylvania, USA Vahri Beaumont, PhD: Department of Pharmacology, University of Bristol, Bristol, United Kingdom; currently Neurobiology Division, Department of Molecular and Cell Biology, University of California at Berkeley, USA Waltraud Binder, PhD: Clinic for Anesthesia and Critical Care Medicine, Benjamin Franklin University Hospital, Free University of Berlin, Germany Sandra R. Chaplan, MD: Department of Anesthesiology, University of California, La Jolla, USA J.-G. Cui, MD: Department of Clinical Neuroscience, Section of Neurosurgery, Karolinska Hospital, Stockholm, Sweden Roman Dertwinkel, MD: Department of Anesthesiology, Intensive Care, and Pain Therapy, Bergmannsheil University Hospital, Ruhr University of Bochum, Germany Anthony H. Dickenson, PhD: Department of Pharmacology, University College, London, United Kingdom Barbara Donner, MD: Department of Anesthesiology, Intensive Care, and Pain Therapy, Bergmannsheil University Hospital, Ruhr University of Bochum, Germany Andy Dray, PhD: Department of Pharmacology, AstraZeneca RandD Montreal, St. Laurent, Quebec, Canada Robert Elde, PhD: Department of Neuroscience, University of Minnesota, Minneapolis, USA Peter J.D. Evans, FRCA: Pain Management Centre, Charing Cross Hospital, London, United Kingdom Gerald F. Gebhart, PhD: Department of Pharmacology, University of Iowa, Iowa City, USA Geoffrey Gourlay, BPharm, PhD: Pain Management Unit, Flinders Medical Centre, Bedford Park, South Australia, Australia Gisele Guilbaud, MD, DSc: Research Unit on the Physiopharmacology of the Nervous System, INSERM, Paris, France Gunnar Grant, MD: Department of Neuroscience, Karolinska Institute, Stockholm, Sweden Stefan Grass, MD: Department of Medical Laboratory Sciences and Technology, Division of Clinical Neurophysiology, Karolinska Institute, Huddinge University Hospital, Sweden Jing-Xia Hao, MD, DMSc: Department of Medical Laboratory Sciences and Technology, Division of Clinical Neurophysiology, Karolinska Institute, Huddinge University Hospital, Sweden Graeme Henderson, PhD: Department of Pharmacology, School of Medical Sciences, Bristol, United Kingdom Orsolya Hoffmann, MD, DMSc: Department of Medical Laboratory Sciences and Technology, Division of Clinical Neurophysiology, Karolinska Institute, Huddinge University Hospital, Sweden Tomas Hokfelt, MD: Department of Neuroscience, Karolinska Institute, Stockholm, Sweden Shailen Joshi, BSPharm: Department of Pharmacology, University of Iowa, Iowa City, USA Gong Ju, MD: Department of Neurobiology, Institute of Neurosciences, The Fourth Military Medical University, Xi'an, P.R. China Eija Kalso, MD, DMedSci: Department of Anesthesia, Helsinki University Central Hospital, Finland; currently Department of Anesthesia and Intensive Care, Karolinska Institute, Huddinge University Hospital, Sweden Valerie Kayser, BPharm, DSc: Research Unit on the Physiopharmacology of the Nervous System, INSERM, Paris, France H. Keita, MD: Research Unit on the Physiopharmacology of the Nervous System, INSERM, Paris, France Ian Kitchen, PhD: Pharmacology Research Group, School of Biological Sciences, University of Surrey, Guildford, Surrey, United Kingdom Josephine Lai, PhD: Department of Pharmacology, Health Sciences Center, University of Arizona, Tucson, USA Bengt Linderoth, MD, PhD: Department of Clinical Neuroscience, Section of Neurosurgery, Karolinska Hospital, Stockholm, Sweden Guilherme de Araujo Lucas, MD, PhD: Department of Medical Laboratory Sciences and Technology, Division of Clinical Neurophysiology, Karolinska Institute, Huddinge University Hospital, Sweden Halina Machelska, PhD: Clinic for Anesthesia and Operative and Intensive Medicine, Benjamin Franklin University Clinic, Free University of Berlin, Germany T. Philip Malan, Jr., MD, PhD: Departments of Pharmacology and Anesthesiology, Health Sciences Center, University of Arizona, Tucson, USA Henry J. McQuay, DM: Pain Relief Unit, Nuffield Department of Anaesthetics, University of Oxford, United Kingdom Bjorn Meyerson, MD, PhD: Department of Clinical Neuroscience, Section of Neurosurgery, Karolinska Hospital, Stockholm, Sweden Michael H. Ossipov, PhD: Department of Pharmacology, Health Sciences Center, University of Arizona, Tucson, USA N. Ozaki, MD, PhD: Department of Pharmacology, College of Medicine, University of Iowa, Iowa City, USA Gavril W. Pasternak, MD, PhD: The Cotzias Laboratory of Neuro-Oncology, Memorial Sloan-Kettering Cancer Center, New York, USA Serger Perrot, MD: Research Unit on the Physiopharmacology of the Nervous System, INSERM, Paris, France Jan Persson, MD, PhD: Pain Section, Department of Anesthesia and Intensive Care, Huddinge University Hospital, Sweden Aida Plesan, MD: Department of Medical Laboratory Sciences and Technology, Division of Clinical Neurophysiology, Karolinska Institute, Huddinge University Hospital, Sweden Frank Porreca, PhD: Departments of Pharmacology and Anesthesiology, Health Sciences Center, University of Arizona, Tucson, USA Maureen Riedl, PhD: Department of Neuroscience, University of Minnesota, Minneapolis, USA Michael Rowbotham, MD: Pain Clinical Research Center and Mount Zion Pain Management Center, University of California, San Francisco, USA Michael Schafer, MD: Clinic for Anesthesia and Critical Care Medicine, Benjamin Franklin University Hospital, Free University of Berlin, Germany J.N. Sengupta, PhD: Department of Pharmacology, University of Iowa, Iowa City, Iowa, USA; currently Gastrointestinal Pharmacology, Astra Hassle, Molendal, Sweden Tiejun Sten Shi, MD: Department of Neuroscience, Karolinska Institute, Stockholm, Sweden Samuel Shuster, PhD: Department of Neuroscience, University of Minnesota, Minneapolis, USA Christoph Stein, MD: Clinic for Anesthesia and Operative and Intensive Medicine, Benjamin Franklin University Clinic, Free University of Berlin, Germany Michael Strumpf, MD: Department of Anesthesiology, Intensive Care, and Pain Therapy, Bergmannsheil University Hospital, Ruhr University of Bochum, Germany Xin Su, MD: Department of Pharmacology, University of Iowa, Iowa City, USA Rie Suzuki, BSc: Department of Pharmacology, University College, London, United Kingdom Young-Guang Tong, MD, DMSc: Department of Neurobiology, Institute of Neurosciences, The Fourth Military Medical University, Xi'an, P.R. China Hui Fredrik Wang: Department of Neuroscience, Karolinska Institute, Stockholm, Sweden Zsuzsanna Wiesenfeld-Hallin, PhD: Department of Medical Laboratory Sciences and Technology, Division of Clinical Neurophysiology, Karolinska Institute, Huddinge University Hospital, Sweden Xiao-Jun Xu, MD, DMSc: Department of Medical Laboratory Sciences and Technology, Division of Clinical Neurophysiology, Karolinska Institute, Huddinge University Hospital, Sweden Zhi-Qing David Xu, MD, DMSc: Department of Neuroscience, Karolinska Institute, Stockholm, Sweden Wei Yu, MD: Department of Medical Laboratory Sciences and Technology, Division of Clinical Neurophysiology, Karolinska Institute, Huddinge University Hospital, Sweden Michael Zenz, MD: Department of Anesthesiology, Intensive Care, and Pain Therapy, Bergmannsheil University Hospital, Ruhr University of Bochum, Germany Xu Zhang, MD, DMSc: Department of Neurobiology, Institute of Neurosciences, The Fourth Military Medical University, Xi'an, P.R. China

Table of Contents

Forewordp. xi
Prefacep. xiii
Acknowledgmentsp. xvi
Function and Dysfunction of Opioid Receptors
Targeting of Opioid Receptors to Presynaptic Sitesp. 1
Function and Dysfunction of Opioid Receptors in the Spinal Cordp. 17
Opioid Receptors in the Peripheryp. 45
Relevance of Proposed Mechanisms of G-Protein-Coupled Receptor Desensitization to Opioid Receptorsp. 59
Modulation of Opioid Analgesia: Tolerance and Beyondp. 83
Clinical Pharmacology of Opioids--Relevant Aspects
Different Opioids--Same Actions?p. 97
Route of Opioid Administration--Does It Make a Difference?p. 117
Clinical Status of Opioid Tolerance in Long-Term Therapy of Chronic Noncancer Painp. 129
Understanding and Improving Opioid Sensitivity--New Perspectives
Phenotypic Changes Induced in Dorsal Root Ganglion Neurons by Nerve Injuryp. 145
Opioid Analgesic Activity in Neuropathic Pain Statesp. 163
Opioid Sensitivity in Experimental Central Pain after Spinal Cord Injury in Ratsp. 183
Antinociceptive Effect of Opioid Substances in Different Models of Inflammatory Painp. 201
Opioid Modulation of Visceral Painp. 225
Opioid Sensitivity in Antinociception: Role of Anti-Opioid Systems with Emphasis on Cholecystokinin and NMDA Receptorsp. 237
Alpha, Omega, and In Betweenp. 253
Alternatives to Mu-Opioid Analgesics: Delta-Opioid- and Galanin-Receptor-Selective Compoundsp. 269
Opioid Gene Knockouts: New Answers to Old Questions?p. 281
Opioid Sensitivity of Different Chronic Pain States--Answers and Questions from the Clinic
The Debate over Opioids and Neuropathic Painp. 307
Opioids and Painful Peripheral Neuropathyp. 319
Efficacy of Peripheral Opioid Analgesia in Inflammatory Pain: Evidence from Clinical Studiesp. 327
Opioids in Ischemic Painp. 337
Opioids for Chronic Musculoskeletal Painp. 349
Opioids in Headachep. 367
How Should We Measure the Outcome?p. 371
Indexp. 385
Table of Contents provided by Syndetics. All Rights Reserved.

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