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9780521802611

Platelets in Thrombotic and Non-Thrombotic Disorders: Pathophysiology, Pharmacology and Therapeutics

by
  • ISBN13:

    9780521802611

  • ISBN10:

    052180261X

  • Format: Hardcover
  • Copyright: 2002-07-08
  • Publisher: Cambridge University Press

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Summary

Platelets have become an important research target for clinicians and basic scientists in a range of medical disciplines. This book reviews current science and applications in fields including thrombosis and hemostasis, signal transduction, and non-thrombotic conditions such as inflammation, allergy and tumor metastasis. It is a detailed, up-to-date, highly referenced text for clinical scientists and physicians, including recent developments in this rapidly expanding field. More than a scientific resource, this is also an authoritative reference and guide to the diagnosis and therapeutics of diseases involving platelets. Chapters are devised to provide a critical review of the most clinically relevant aspects of the subject. It will be an essential reference for biomedical scientists and clinicians in hematology, vascular medicine, cardiology, thrombosis and related disciplines.

Table of Contents

List of contributors
ix
Editors' preface xxi
PART I PHYSIOLOGY
History of platelets
3(22)
J. Fraser Mustard
Raelene L. Kinlough-Rathbone
Marian A. Packham
Production of platelets
25(16)
Arnaud Drouin
Elisabeth Cramer
Morphology and ultrastructure of platelets
41(29)
James G. White
Platelet heterogeneity: physiology and pathological consequences
70(10)
Anthony Mathur
John F. Martin
Platelet membrane proteins as adhesion receptors
80(13)
Yoshiaki Tomiyama
Masamichi Shiraga
Sanford J. Shattil
Dynamics of the platelet cytoskeleton
93(11)
Kurt L. Barkalow
Herve Falet
John Hartwig
Platelet organelles
104(9)
Francine Rendu
Brigitte Brohard-Bohn
Platelet receptors for thrombin
113(14)
Lawrence F. Brass
Marina Molino
Peter J. O'Brien
Mark Kahn
Platelet receptors: ADP
127(13)
Christian Gachet
Jean-Pierre Cazenave
Platelet receptors: prostanoids
140(18)
Roberta Vezza
Garret A. FitzGerald
Platelet receptors: collagen
158(21)
Pia R-M. Siljander
Richard W. Farndale
Platelet receptors: von Willebrand factor
179(9)
Jerry Ware
Zaverio M. Ruggeri
Platelet receptors: fibrinogen
188(16)
Edward F. Plow
Thomas A. Haas
Tatiana V. Byzova
Platelet signalling: GTP-binding proteins
204(17)
Jan-Willem N. Akkerman
Platelet phospholipases A2
221(17)
Michael H. Gelb
Carine M. Mounier
Ying Hefner
Steve P. Watson
Roles of phospholipase C and phospholipase D in receptor-mediated platelet activation
238(22)
Mauro Torti
Eduardo G. Lapetina
Platelet signalling: calcium
260(12)
Juan A. Rosado
Stewart O. Sage
Platelet signalling: protein kinase C
272(9)
Charles S. Abrams
Marcelo G. Kazanietz
Platelet signalling: tyrosine kinases
281(9)
Sylviane Levy-Toledano
Platelet signalling: cAMP and cGMP
290(14)
James L. Daniel
Barrie Ashby
Fabio M. Pulcinelli
Platelet adhesion
304(15)
Philip G. de Groot
Jan J. Sixma
The platelet shape change
319(19)
Adrian R.L. Gear
Renata K. Polanowsa-Grabowska
Aggregation
338(19)
Marian A. Packham
Margaret L. Rand
Raelene L. Kinlough-Rathbone
Amplification loops: release reaction
357(12)
Marc F. Hoylaerts
Amplification loops: thromboxane generation
369(12)
Paola Patrignani
Maria G. Sciulli
Platelet procoagulant activities: the amplification loops between platelets and the plasmatic clotting system
381(12)
H. Coenraad Hemker
Platelets and chemotaxis
393(19)
Stefania Momi
Paolo Gresele
Platelet-leukocyte interactions relevant to vascular damage and thrombosis
412(20)
Chiara Cerletti
Virgilio Evangelista
Roberto Lorenzet
Giovanni de Gaetano
Vascular control of platelet function
432(27)
Scott Willoughby
Joseph Loscalzo
PART II METHODOLOGY
In vitro assays for evaluating platelet function
459(12)
Perumal Thiagarajan
Kenneth K. Wu
Monitoring antiplatelet therapy
471(14)
Dermot Cox
Desmond Fitzgerald
Flow cytometric analysis of platelet function
485(14)
Alan D. Michelson
Marc R. Barnard
Lori A. Krueger
A.L. Frelinger III
Mark I. Furman
Animal models of platelet-dependent thrombosis
499(16)
Paolo Golino
Francesco Loffredo
PART III PATHOLOGY
A Hemostasis
Hereditary thrombocytopenias
515(13)
Chris Van Geet
Kathleen Freson
Rita Devos
Jos Vermylen
Thrombocytopenias due to bone marrow disorders
528(14)
Beng H. Chong
Colin Chesterman
Immune-mediated thrombocytopenia
542(14)
Kathryn E. Webert
John G. Kelton
Thrombocytopenia in childhood
556(13)
Cecile Kaplan
M. Dreyfus
V. Proulle
G. Tchernia
Alloimmune thrombocytopenia
569(15)
E. Anders Kolb
James B. Bussel
Drug-induced and drug-dependent immune thrombocytopenias
584(26)
Andreas Greinacher
Petra Eichler
Norbet Lubenow
Thrombotic thrombocytopenic purpura and hemolytic uremic syndrome
610(13)
Miha Furlan
Thrombocytosis and thrombocythemia
623(16)
Tiziano Barbui
Guido Finazzi
Platelet adhesive protein
639(16)
Kenneth J. Clemetson
Jeannine M. Clemetson
Congenital disorders of platelet secretion
655(19)
Marco Cattaneo
Congenital platelet signal transduction defects
674(15)
A. Koneti Rao
Acquired platelet function defects
689(18)
Joel S. Bennett
Platelet storage and transfusion
707(20)
Scott Murphy
B Thrombosis
Pathophysiology of arterial thrombosis
727(11)
Lina Badimon
Juan-lose Badimon
Valentin Fuster
Platelets and atherosclerosis
738(15)
Peter Verhamme
Paul Holvoet
Platelet involvement in venous thrombosis and pulmonary embolism
753(7)
Andrew D. Blann
Gregory Y. H. Lip
Gene regulation of platelet function
760(23)
Thomas J. Kunicki
C Non-hemostatic disorders
Platelets and bacterial infections
783(24)
Mark C. Herzberg
Ke Gong
Interactions of viruses and platelets and the inactivation of viruses in platelet concentrates prepared far transfusion
807(8)
Laurence Corash
Platelets and parasites
815(9)
Michel Joseph
Platelets and tumours
824(13)
Maria Benedetta Donati
Virgilio Evangelista
Platelets and renal diseases
837(15)
Paola Boccardo
Miriam Galbusera
Giuseppe Remuzzi
Platelets and allergic diseases
852(17)
Simon Pitchford
Clive P. Page
Platelet interactions with other cells related to inflammatory diseases
869(16)
Patrice E. Poubelle
Pierre Borgeat
Platelets and the preimplantation stage of embryo development
885(9)
Christopher O'Neill
Platelets in psychiatric and neurological disorders
894(13)
B. E. Leonard
Platelets in inflammatory bowel disease
907(12)
Elizabeth Carty
David S. Rampton
Carole E. Collins
PART IV PHARMACOLOGY
Aspirin
919(10)
Carlo Patrono
Pharmacology of ticlopidine and clopidogrel
929(11)
Jean-Pierre Cazenave
Christian Gachet
Platelet membrane glycoprotein (GP) IIb-IIIa antagonists and acute arterial thrombosis
940(15)
David R. Phillips
Lisa Nannizzi-Alaimo
Other antiplatelet agents
955(9)
Luigi Iuliano
Fausta Micheletta
Francesco Violi
Pharmacogenetics as a new antiplatelet strategy
964(14)
Giovanni de Gaetano
Chiara Cerletti
Licia Iacoviello
Cardiovascular gene therapy: implications for platelet vessel wall interactions
978(13)
Pierre Zoldhelyi
Harold Eichstaedt
Thomas Jax
Janice M. McNatt
Zhi Qiang Chen
Harnath S. Shelat
Harris Rose
James T. Willerson
Pharmacological modulation of the inflammatory actions of platelets
991(12)
Carla Cicala
Giuseppe Cirino
PART V THERAPY
Design of trials to evaluate antiplatelet agents
1003(10)
Shamir R. Mehta
John W. Eikelboom
Salim
Antiplatelet therapy in cardiology
1013(27)
Herbert D. Aronow
Eric J. Topol
Antiplatelet therapies in neurology
1040(15)
Graeme J. Hankey
Antiplatelet treatment in peripheral vascular disease
1055(8)
Raymond Verhaeghe
Afterword Platelets: a personal story 1063(10)
Gustav V. R. Born
Index 1073

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