Secondary Schizophrenia

by Edited by Perminder S. Sachdev , Matcheri S. Keshavan

• ISBN13: 9780521856973
• ISBN10: 0521856973
• eBook ISBN(s): 9780511848674
• Edition: 1st
• Format: Hardcover
• Copyright: 2010-03-15
• Publisher: Cambridge University Press
• More Book Details
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Summary

Schizophrenia may not be a single disease, but the result of a diverse set of related conditions. Modern neuroscience is beginning to reveal some of the genetic and environmental underpinnings of schizophrenia; however, an approach less well travelled is to examine the medical disorders that produce symptoms resembling schizophrenia. This book is the first major attempt to bring together the diseases that produce what has been termed 'secondary schizophrenia'. International experts from diverse backgrounds ask the questions: does this medical disorder, or drug, or condition cause psychosis? If yes, does it resemble schizophrenia? What mechanisms form the basis of this relationship? What implications does this understanding have for aetiology and treatment? The answers are a feast for clinicians and researchers of psychosis and schizophrenia. They mark the next step in trying to meet the most important challenge to modern neuroscience - understanding and conquering this most mysterious of human diseases.

Author Biography

Perminder S. Sachdev is Scientia Professor of Neuropsychiatry at the school of Psychiatry, university of New south Wales, and Clinical Director of the Neuropsychiatric institute (NPI), the Prince of Wales Hospital, Sydney, Australia. MatchEri S. Keshavan is Professor and Vice Chair of Psychiatry, Beth Israel Deaconess Medical center, Harvard Medical School, Boston, Massaachusetts, USA.

Table of Contents

List of contributors	p. vii
Preface	p. xiii
Introduction
Neurobiology and etiology of primary schizophrenia: current status	p. 3
The concept of organicity and its application to schizophrenia	p. 16
Secondary hallucinations	p. 21
The neurology of schizophrenia
The neurologic examination in schizophrenia	p. 47
Functional neuroimaging in schizophrenia	p. 60
Organic syndromes of schizophrenia
Epilepsy and schizophrenia
Schizophrenia-like psychosis and epilepsy	p. 79
Understanding the pathophysiology of schizophrenia through the looking glass of forced normalization	p. 103
Drugs and schizophrenia-like psychosis
Substance-induced psychosis: an overview	p. 112
Stimulants and psychosis	p. 127
Psychotomimetic effects of PCP, LSD, and Ecstasy: pharmacological models of schizophrenia?	p. 141
Schizophrenia secondary to cannabis use	p. 169
Toxic psychosis	p. 179
Other neurological disorders
Schizophrenia-like psychosis and traumatic brain injury	p. 186
Cerebrovascular disease and psychosis	p. 197
Neurodegenerative disorders (Alzheimer's Disease, fronto-temporal dementia) and schizophrenia-like psychosis	p. 204
Storage disorders and psychosis	p. 214
Mitochondrial disorders and psychosis	p. 229
Psychosis associated with leukodystrophies	p. 241
Normal pressure hydrocephalus	p. 257
Brain tumors	p. 263
Demyelinating disease and psychosis	p. 273
Systemic disorders
Infection and schizophrenia	p. 279
Genetic disorders related to SLP
The status of genetic investigations of schizophrenia	p. 288
Velocardiofacial syndrome (chromosome 22q11.2 deletion syndrome) as a model of schizophrenia	p. 309
Psychosis in Prader-Willi Syndrome	p. 328
Friedreich's Ataxia and schizophrenia-like psychosis	p. 332
Wilson's Disease	p. 337
Huntington's Disease and related disorders and their association with schizophrenia-like psychosis	p. 348
Fahr's Disease and psychosis	p. 358
Related concepts
The Charles Bonne tSyndrome	p. 369
Acute brief psychosis-an organic syndrome?	p. 380
Treatment
Drug treatment of secondary schizophrenia	p. 393
Nonpharmacological interventions in secondary schizophrenia	p. 406
Index	p. 419
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