Sensory Neurons Diversity, Development, and Plasticity

by Scott, Sheryl A.

• ISBN13: 9780195066760
• ISBN10: 0195066766
• Format: Hardcover
• Copyright: 1992-10-01
• Publisher: Oxford University Press

Summary

Vertebrate sensory neurons occupy a unique place in the nervous system, conveying information from the periphery to the CNS. While sensory physiologists have long recognized differences in response properties among cells in dorsal root and cranial ganglia, the full extent of heterogeneity among these neurons has only recently become apparent. Phenotypic diversity is the underlying theme of this unique work, which summarizes our current understanding of the individual characteristics and development of sensory neurons. The chapters are arranged in three cohesive sections. The first describes heterogeneity in the function, biochemical make-up, ion channels, membrane properties, and central projection patterns of dorsal root ganglion neurons. The second section discusses the development of sensory neurons, covering such topics as the origins of dorsal root and cranial ganglia, adhesive interactions involved in axon outgrowth, trophic dependence of sensory neurons, and the development of the physiological properties and central and peripheral connections of dorsal root ganglion neurons. The last section explains regeneration and plasticity of mature neurons, including sprouting of skin sensory axons, plasticity in central terminations, axotomy and regeneration, and the continuing role of neurotrophic factors in adult neurons.

Table of Contents

Function of Dorsal Root Ganglion Neurons: An Overview

Phenotypic Diversity Among Sensory Neurons

Morphological and Biochemical Cell Types of Sensory Neurons

The Organization of Biochemically Characterized Sensory Neurons

Functional Heterogeneity of Dorsal Root Ganglion Cells

Voltage-gated Ion Channels in Dorsal Root Ganglion Neurons

Somatotopic Organization of Primary Afferent Projections to the Spinal Cord

Laminar Organization of Primary Afferent Termination in the Mammalian Spinal Cord

Development of Sensory Neurons

The Cellular and Molecular Basis of Early Sensory Ganglion Development

Origins of Early Development of Vertebrate Cranial Sensory Neurons

Cell Death and the Trophic Requirements of Developing Sensory Neurons

Adhesive Interactions That Regulate Neuronal Behavior

The Development of Peripheral Sensory Innervation Patterns

The Development of Muscle Afferent Connections in the Vertebrate Spinal Cord

The Physiological Properties of Developing Sensory Neurons

Regeneration and Plasticity in Mature Sensory Neurons

Regulation the Sensory Innervation of Skin: Trophic Control of Collateral Sprouting

Plasticity of Central Terminations of Primary Sensory Neurons in the Adult Animal

Axotomy-induced Changes in Primary Sensory Neurons

Specificity of Regenerating Sensory Neurons in Adult Mammals

The Role of Neurotrophic Factors in Functional Maintenance of Mature Sensory Neurons

Table of Contents provided by Publisher. All Rights Reserved.