Sigma Receptors

by Matsumoto, Rae R.; Bowen, Wayne Darrell; Su, Tsung-ping

• ISBN13: 9780387365121
• ISBN10: 0387365125
• Edition: 1st
• Format: Hardcover
• Copyright: 2006-11-03
• Publisher: Springer Verlag

Summary

This book provides an update on sigma receptors, and summarizes recent advances in the medicinal chemistry, molecular biology, and cell biology of sigma receptors. It describes the functional effects mediated by these receptors and the potential clinical implications of these actions. This information is put in a historical perspective to help newcomers to the field successfully navigate the confusing early history surrounding these proteins, and provides a launching point from which future studies and research directions can easily be developed. Major advances in our understanding of sigma receptors have been made during the past few years. This book will facilitate exciting new research that could lead to significant advances in the treatment of neurologic, psychiatric, cardiovascular, immunologic, and gastrointestinal disorders through a better understanding of sigma receptors.

Table of Contents

Contributing Authors	p. vii
Preface	p. xi
[sigma] Receptors: Historical Perspective and Background	p. 1
Medicinal Chemistry: New Chemical Classes and Subtype-Selective Ligands	p. 25
Irreversible [sigma] Compounds	p. 45
Pharmacophore Models for [sigma][subscript 1] Receptor Binding	p. 71
Cloning of [sigma][subscript 1] Receptor and Structural Analysis of its Gene and Promoter Region	p. 99
Site-Directed Mutagenesis	p. 113
[sigma] Receptor Modulation of Ion Channels	p. 127
Subcellular Localization and Intracellular Dynamics of [sigma][subscript 1] Receptors	p. 151
Intracellular Signaling and Synaptic Plasticity	p. 165
Modulation of Classical Neurotransmitter Systems by [sigma] Receptors	p. 195
[sigma][subscript 2] Receptors: Regulation of Cell Growth and Implications for Cancer Diagnosis and Therapeutics	p. 215
Cognitive Effects of [sigma] Receptor Ligands	p. 237
[sigma] Receptors and Schizophrenia	p. 273
Potential Role of [sigma] Ligands and Neurosteroids in Major Depression	p. 293
[sigma] Receptors and Drug Abuse	p. 315
[sigma][subscript 1] Receptors and the Modulation of Opiate Analgesics	p. 337
[sigma] Receptors in the Immune System: Implications for Potential Therapeutic Intervention - an Overview	p. 351
[sigma] Receptors and Gastrointestinal Function	p. 371
Appendix	p. 393
Index	p. 405
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