Signal Transduction and Cardiac Hypertrophy

by World Heart Congress 2001; Dhalla, Naranjan S.; Hryshko, Larry V.; Kardami, Elissavet; Singal, Pawan K.

• ISBN13: 9781402072185
• ISBN10: 140207218X
• Format: Hardcover
• Copyright: 2003-01-01
• Publisher: Kluwer Academic Pub

Summary

The limitation in number of donor hearts led to the establishment of alternative treatments such as left ventricular assist devices (LVAD), which have been used. Although several reports suggest the native ventricular function recovers after long-term LVAD support - a process called "reverse remodeling" - the underlying biological mechanisms are unclarified. Various molecular pathways of the human myocardium associated with apoptosis, response to stress, or matrix changes are known to be altered under conditions of heart failure and some of them have been shown to be reversible regulated during left ventricular mechanical support. This suggests that the "reverse remodeling" is actually, at least in part, a reverse mechanism. One explanation may be, under mechanical circulatory assist, volume and pressure overload is reduced, and thus ventricular wall stress decreases, leading to improved myocardial blood supply. This may be one explanation for the molecular myocardial changes, and may reflect a possible cause of "reverse remodeling".

Table of Contents

Dedication: A Tribute to Dr. Jutta Schaper	xi
Preface	xiii
Acknowledgments	xv
I. CARDIAC ADAPTATION AND REMODELING	1	(136)
Molecular Changes of the Myocardium After Mechanical Circulatory Support	3	(16)
Florian Grabellus
Bodo Levkau
Hans-H. Scheld
Atsushi Takeda
Michael Erren
Jorg Stypmann
Hideo A. Baba
Reverse Molecular Remodeling of the Failing Human Heart Following Support with a Left Ventricular Assist Device	19	(18)
Paul M. Heerdt
Daniel Burkoff
Stretch-Elicited Autocrine/Paracrine Mechanism in the Heart	37	(12)
Horacio E. Cingolani
Nestor G. Perez
Maria C. Camilion De Hurtado
L-Arginine at the Crossroads of Biochemical Pathways Involved in Myocardial Hypertrophy	49	(8)
Emanuele Giordano
Lisa M. Shantz
Rebecca A. Hillary
Carlo Guarnieri
Claudio M. Caldarera
Anthony E. Pegg
Signal Transduction System in Human Aortic Smooth Muscle Cell Stimulated by Pure Pressure	57	(12)
Hideaki Kawaguchi
Noriteru Morita
Takeshi Murakami
Kenji Ilzuka
Role of Mitochondrial KATP Channels in Improved Ischemic Tolerance of Chronically Hypoxic Adult and Immature Hearts	69	(16)
Frantisek Kolar
Ivana Ostadalova
Bohuslav Ostadal
Jan Neckar
Ondrej Szarszoi
Ca2+-Dependent Signaling Pathways Through Calcineurin and Ca2+/Calmodulin-Dependent Protein Kinase in Development of Cardiac Hypertrophy	85	(10)
Hiroyuki Takano
Yunzeng Zou
Hiroshi Akazawa
Toshio Nagal
Miho Mizukami
Haruhiro Toko
Issei Komuro
Calreticulin, Cardiac Development and Congenital Complete Heart Block in Children	95	(10)
Barbara Knoblach
Kimotoshi Nakamura
Murray Robertson
Marek Michalak
Expression of Sodium-Calcium Exchanger Genes in Heart and Skeletal Muscle Development. Evidence for a Role of Adjacent Cells in Regulation of Transcription and Splicing	105	(20)
Marie Millour
Laurent Lescaudron
Alexander Kraev
Dmitri O. Levitsky
Na+/H+ Exchanger and Myocardial Hypertrophy	125	(12)
Maria C. Camilion De Hurtado
Nestor G. Perez
Irene L. Ennis
Bernardo V. Alvarez
Horacio E. Cingolani
II. CARDIAC SIGNAL TRANSDUCTION	137	(220)
Role of the Electrogenic Na+/HCO3-- Symport in the Heart	139	(10)
Ernesto Alejandro Aiello
Modulation of Atrial Natriuretic Peptide (ANP)-C Receptor and Associated Signaling by Vasoactive Peptides	149	(18)
Madhu B. Anand-Srivastava
Malika Boumati
RAB3 Small GTP-Binding Proteins: Regulation by Calcium/Calmodulin	167	(14)
Ranjinder S. Sidhu
Richard R. Clough
Rajinder P. Bhullar
Novel Aspects of Mechanical Signaling in Cardiac Tissue	181	(18)
Robert Denyer
Sandhya Sanghi
Rajesh Kumar
David E. Dostal
Caspase Activation in a Cardiac Cell-Free Model of Apoptosis	199	(8)
Claudio Stefanelli
Carla Pignatti
Benedetta Tantini
Emanuele D. Giordano
Francesca Bonavita
Maddalena Zini
Flavio Flamigni
Claudio Muscari
Carlo Clo
Claudio M. Caldarera
Carlo Guarnieri
The Role of the Voltage-Sensitive Release Mechanism in Contraction of Normal and Diseased Heart	207	(14)
Susan E. Howlett
Gregory R. Ferrier
Role of AT1, Receptor Blockade in Reperfused Myocardial Infarction	221	(16)
Bodh I. Jugdutt
Relation Between Intracellular Ca2+ Concentration and Contraction in Tetanized Myocyctes of Rat and Mouse	237	(12)
Kenichi Hongo
Yoichiro Kusakari
Makoto Kawal
Masato Konishi
Seibu Mochizuki
Satoshi Kurihara
The Role of Hydrogen Peroxide as a Signaling Molecule	249	(16)
Michael P. Czubryt
Grant N. Pierce
Localized Control of Oxidative Phosphorylation within Intracellular Energetic Units in Heart Cells: A Possible Solution of Some Old Problems	265	(20)
Valdur Saks
Florence Appaix
Yves Usson
Karen Guerrero
Jose Olivares
Enn Seppet
Mayis Aliev
Raimund Margreiter
Andrey Kuznetsov
Role of High Molecular Weight Calmodulin Binding Protein in Cardiac Muscle	285	(18)
Lakshmikuttyamma Ashakumary
Rakesh Kakkar
Ponniah Selvakumar
Mohammed Khysar Pasha
Rajendra K. Sharma
β-Adrenergic Signaling in Chronic Heart Failure---Friend or Foe?	303	(20)
Christoph Maack
Michael Bohm
Compartmentation to Lipid Rafts as a Mechanism to Regulate β-Adrenergic Receptor Signaling in Cardiomyocytes	323	(12)
Susan F. Steinberg
Role of Renin--Angiotensin System in Phospholipase C-Mediated Signaling in Congestive Heart Failure	335	(14)
Paramjit S. Tappia
Nina Aroutiounova
Naranjan S. Dhalla
JAK/Stat Signaling in Cardiac Diseases	349	(8)
M.A.Q. Siddiqui
Eduardo Mascareno
III. GENETIC APPROACHES TO INVESTIGATIVE CARDIAC SIGNAL TRANSDUCTION	357	(140)
Signaling Pathways Involved in the Stimulation of DNA Synthesis by Tumor Necrosis Factor and Lipopolysaccharide in Chick Embryo Cardiomyocytes	359	(14)
Benedetta Tantini
Carla Pignatti
Flavio Flamigni
Claudio Stefanelli
Monia Fattori
Annalisa Facchini
Emanuele Giordano
Carlo Clo
Claudio Marcello Caldarera
The Application of Genetic Mouse Models to Elucidate a Role for Fibroblast Growth Factor-2 in the Mammalian Cardiovascular System	373	(20)
Karen A. Detillieux
Sarah K. Jiminez
David P. Sontag
Elissavet Kardami
Peter W. Nickerson
Peter A. Cattini
Interaction of COUP-TF II With the Rat Carnitine Palmitoyltransferase I B Promoter in Neonatal Rat Cardiac Myocytes	393	(10)
Guo-Li Wang
Meredith Moore
Jeanie B. Mcmillan
Altered Expression of Conventional Calpains Influences Apoptosis	403	(14)
Ronald L. Mellgren
Tao Lu
Ying Xu
KLF5/BTEB2, a Kruppel-Like Transcription Factor, Regulates Smooth Muscle Phenotypic Modulation	417	(8)
Ryozo Nagai
Takayuki Shindo
Ichiro Manabe
Toru Suzuki
Kennichi Aizawa
Saku Miyamoto
Shinsuke Muto
Keiko Kawai-Kowase
Masahiko Kurabayashi
Transgenic Manipulation of SERCA and PLB Levels and Their Effect on Cardiac Contractility	425	(14)
Kalpana J. Nattamai
Muthu Periasamy
Expression of Vascular Endothelial Growth Factor and Hypoxia-Inducible Factor 1α in the Myocardium	439	(10)
Toshiyuki Takahashi
Yauyuki Sugishita
Tatsuya Shimizu
Atsushi Yao
Kazamasa Harada
Ryozo Nagai
Gene-Based Therapy of Advanced Heart Failure Secondary to the Disruption of Dystrophin-Related Proteom	449	(12)
Teruhiko Toyo-Oka
Tomie Kawada
Adaptation to Ischemia by In Vivo Exposure to Hyperoxia-Signalling Through Mitogen Activated Protein Kinases and Nuclear Factor Kappa B	461	(18)
Guro Valen
Peeter Tahepold
Joel Starkopf
Arno Ruusalepp
Jarle Vaage
The SERCA2 Gene: Genomic Organization and Promoter Characterization	479	(18)
Angel Zarain-Herzberg
Georgina Alvarez-Fernandez
Index	497