Signal Transduction in the Cardiovascular System in Health and Disease

by Srivastava, Ashok K.; Anand-srivastava, Madhu B.

• ISBN13: 9780387095516
• ISBN10: 0387095519
• Edition: 1st
• Format: Hardcover
• Copyright: 2008-10-30
• Publisher: Springer Verlag

Summary

This book has addressed the contributions of several key signal transduction pathways which are central to our understanding of cardiovascular physiology and pathophysiology. Aberrations in these signaling events have been suggested to be involved in a host of cardiovascular pathologies, such as cardiac arrhythmias, congenital heart failure and hypertension.

Table of Contents

Contributors	p. xiii
G-protein-Coupled Receptor Signaling
Implication of G-proteins in Cardiovascular Disease	p. 3
[beta]-Adrenoceptor-Linked Signal Transduction Mechanisms in Congestive Heart Failure	p. 27
Cardiac G[alpha]s and G[alpha]i Modulate Sympathetic Versus Parasympathetic Mechanisms in Hyperhomocysteinemia	p. 51
The Role of the Beta-Adrenergic Signal Transduction Pathway in Myocardial Protection	p. 67
Angiotensin II Signaling in Vascular Physiology and Pathophysiology	p. 89
Angiotensin II Signaling: Cell Growth and Apoptosis	p. 117
Redox Signaling
Thioredoxin Signaling in the Ischemic Heart	p. 141
Relationship Between Redox Regulation and [beta]-Adrenergic Responses in the Heart	p. 157
Role of Hyperglycemia and Redox-Induced Signaling in Vascular Complications of Diabetes	p. 177
Methylglyoxal and Insulin Resistance	p. 193
Growth Factor Signaling
Role of Growth Factor Receptor Transactivation in Vasoactive Peptide-Induced Signaling Pathways in Vascular Smooth Muscle Cells	p. 211
Identifying the Cellular and Molecular Events Associated with the Divergent Phenotypes of Cardiac Hypertrophy	p. 229
Regulatory Role of TGF-[beta] in Cardiac Myofibroblast Function and Post-MI Cardiac Fibrosis: Key Roles of Smad7 and c-Ski	p. 249
The Signaling Duel Between Virus and Host: Impact on Coxsackieviral Pathogenesis	p. 267
Therapeutic Angiogenesis and Vasculogenesis for Ischemic Disease	p. 285
VEGF Signaling: A Therapeutic Target for Cardiovascular Disease	p. 301
Myristoyl-CoA:Protein N-Myristoyltransferase and Myristoyl-CoA Binding Protein from Bovine Cardiac Muscle	p. 327
Calcium Signaling
Ca[superscript 2+]/Calmodulin-Dependent Protein Kinase II Signaling in Vascular Smooth Muscle	p. 339
The KCa3.1 Channel in Endothelial Cells as New Target for an EDHF-Based Control of Vascular Tone: From Structure to Regulation and Pharmacological Properties	p. 357
Adipokine Signaling
Leptin Signaling in the Cardiovascular System	p. 377
AMPK Regulation of Cardiac Metabolism in Heart Disease	p. 397
About the Editors	p. 411
Index	p. 413
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