Signaling Pathways in Liver Diseases

by Trautwein, Christian

• ISBN13: 9783540229346
• ISBN10: 3540229345
• Edition: 1st
• Format: Hardcover
• Copyright: 2005-06-30
• Publisher: Springer Verlag

Summary

Recent advances have carried hepatology to new frontiers. The increasing frequency with which steatotic and cirrhotic livers undergo surgery obliges liver surgeons and hepatologists to understand the molecular mechanisms at play in these situations. Comprehension of the signaling pathways participating in liver regeneration, hepatocellular apoptosis and ischemia/reperfusion injury is essential. This book serves as a source of information to facilitate the reading of the literature and the planning of trials. Translational medicine implies knowledge of the molecular targets of novel therapeutic strategies. It is our goal to stimulate more research that can lead to more exchanges between the laboratory, the clinical ward and the operating room.

Author Biography

Prof. J.-F. Dufour, hepatologist at the University of Bern, is internationally recognized for bridging basic science and clincial practice.Prof. P.-A. Clavien, head of visceral surgery University Hospital Z++rich, is a world renown investigator in the field of liver ischemia/reperfusion injury. Prof. Clavien successfully lead multi-authored texts having already published 3 books as editor: Malignant Liver Tumors, Blackwell Science Inc., May 1999Medical Care of the Liver Transplant Patient (Killenberg/Clavien), Blackwell Science Inc.Diseases of the Gallbladder and Bile Ducts: Diagnosis and Treatment (Clavien/Baillie),Blackwell Science Inc.

Table of Contents

Part I: Cell Types and Matrix	1	(72)
Hepatocytes	3	(14)
Giuliano Ramadori
Bernhard Saile
Signaling Pathways in Biliary Epithelial Cells	17	(10)
M. Fatima Leite
Michael H. Nathanson
Stellate Cells	27	(18)
Massimo Pinzani
Fabio Marra
Kupffer Cells	45	(8)
Manfred Bilzer
Alexander L. Gerbes
Hepatic Sinusoidal Endothelial Cells	53	(10)
Roman E. Perri
Vijay Shah
Extracellular Matrix	63	(10)
Alex Y. Hui
Scott L. Friedman
Part II: Specific Signaling Pathways	73	(332)
IL-6/gp130/Stat3	77	(14)
Rebecca Taub
Vascular Endothelial Growth Factor Signaling	91	(14)
David Semela
Jean-Francois Dufour
Insulin Pathway	105	(10)
Miran Kim
Jack R. Wands
Nature and Function of Hepatic Tumor Necrosis Factor-α Signaling	115	(14)
Jorn M. Schattenberg
Mark J. Czaja
The Fas/FasL Signaling Pathway	129	(10)
Maria Eugenia Guicciardi
Gregory J. Gores
TGF-β and the Smad Pathway in Liver Fibrogenesis	139	(12)
Axel M. Gressner
Steven Dooley
Ralf Weiskirchen
Interferon Signaling	151	(14)
Massimo Levrero
CD14 and Toll Receptor	165	(8)
Allan Tsung
David A. Geller
The Wnt/β-Catenin Pathway	173	(20)
Satdarshan P.S. Monga
George K. Michalopoulos
Notch Signaling in Liver Disease	193	(8)
Sarbjit Nijjar
Alastair Strain
Extracellular ATP: Emerging Roles of Purinergic Signaling	201	(10)
David Gatof
J. Gregory Fitz
Calcium Signaling	211	(12)
Lawrence D. Gaspers
Nicola Pierobon
Andrew P. Thomas
MAP Kinase Pathways in the Control of Hepatocyte Growth, Metabolism and Survival	223	(16)
Paul Dent
PI3K, PTEN and Akt	239	(20)
Thomas F. Franke
Daniel C. Berwick
TOR Signaling and Cell Growth Control	259	(8)
Lisa M. Ballou
Richard Z. Lin
Peroxisome Proliferator Activated Receptors	267	(14)
Raphael Genolet
Liliane Michalik
Walter Wahli
Transcriptional Response to cAMP in the Liver	281	(10)
Maria Agnese Della Fazia
Giuseppe Servillo
Paolo Sassone-Corsi
Heme Oxygenase System	291	(8)
Sei-ichiro Tsuchihashi
Ronald W. Busuttil
Jerzy W. Kupiec-Weglinski
Nitric Oxide	299	(12)
Jose M. Prince
Timothy R. Billiar
Hypoxia-Inducible Factor-1 Signaling System	311	(14)
Deborah Stroka
Daniel Candinas
Cyclins and CDKs in Liver Diseases	325	(8)
Siu Tim Cheung
Ronnie T. Poon
Telomeres and Telomerase: Distinctive Roles in Liver Regeneration, Cirrhosis and Carcinogenesis	333	(8)
Ande Satyanarayana
K. Lenhard Rudolph
NF-kB	341	(12)
Tom Ludde
Christian Trautwein
Ceramide: Cell Regulation from a Lipid Perspective	353	(14)
Jeffrey A. Jones
Yusuf A. Hannun
Apoptosis and Mitochondria	367	(10)
Jose C. Fernandez-Checa
Carmen Garcia-Ruiz
Ubiquitin-Proteasome Pathway in the Pathogenesis of Liver Disease	377	(14)
Samuel W. French
Fawzia Bardag-Gorce
Biological Clock in the Liver	391	(14)
Hitoshi Okamura
Part III: Horizons	405	(28)
Pharmacogenomics of Cholestatic Liver Disease	407	(10)
Christiane Pauli-Magnus
Marie V. St-Pierre
Peter J. Meier
Proteomics of Signal Transduction Pathways	417	(16)
Oliver Kleiner
Jasminka Godovac-Zimmermann
Subject Index	433