Small GTPases in Disease, Part A

by Balch; Der; Hall

• ISBN13: 9780123739681
• ISBN10: 0123739683
• Edition: 1st
• Format: Hardcover
• Copyright: 2008-04-25
• Publisher: Elsevier Science

Summary

The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with over 400 volumes (all of them still in print), the series contains much material still relevant todaytruly an essential publication for researchers in all fields of life sciences. Methods in Enzymology is now available online at ScienceDirect full-text online of volumes 1 onwards. For more information about the Elsevier Book Series on ScienceDirect Program, please visit: http://www.info.sciencedirect.com/bookseries/ This volume is the second of two planned volumes on the topic of globin and other nitric oxide-reactive proteins.

Table of Contents

Rab1b silencing using small interfering RNA for analysis of disease specific function

Rab8-optineurin-myosin VI: Analysis of interactions and functions in the secretory pathway

Characterization of Rab27a and JFC1 as constituents of the secretory machinery of prostate specific antigen in prostate carcinoma cells

In vitro assays to characterize inhibitors of the activation of small G proteins by their guanine nucleotide exchange factors

Analysis of small GTPase function in trypanosomes

Use of dynasore, the small molecule inhibitor of dynamin, in the regulation of endocytosis

Identification and verification of Sro7p as an effector of the Sec4p rab GTPase

Characterization of Rab18, a Lipid Droplet Associated Small GTPase

Analysis on the Emerging Role of of Rab3 GTPase-activating Protein in Warburg Micro and Martsolf Syndrome

Identification and Characterization of JRAB/MICAL-L2, a Junctional Rab13-binding Protein

A SMAP Gene Family Encoding ARF GTPase-activating Proteins and Its Implication in Membrane Trafficking

In vitro and in vivo analysis of neurotrophin-3 activation of Arf6 and Rac-1.

Methods for analysis of rab27a/munc13-4 in secretory lysosome release in haematopoietic cells

Analysis and expression of Rab38 in Oculocutaneous

Analysis of Rab1 function in cardiomyocyte growth

Regulation of the Trafficking and Function of G Protein-coupled Receptors by Rab1 GTPase in Cardiomyoctyes

Regulation of endosome dynamics by Rab5 and its Huntingtin-HAP40 effector complex in physiological versus pathological conditions

Biochemical and Biophysical Analyses of Ras Modification by Ubiquitin

Biochemical Characterization of Novel Germline BRAF and MEK Mutations in Cardio-facio-cutaneous Syndrome

Biochemical and biological characterization of tumor-associated mutations of p110a

Characterization of the Rheb-mTOR signaling pathway in mammalian cells: Constitutive active mutants of Rheb and mTOR

Characterization of RalB-Sec5-TBK1 Function in Human Oncogenesis

High-throughput lung cancer cell line screening for genotype-correlated sensitivity to an EGFR kinase inhibitor

In vitro signalling by MAPK and NFkB pathyways inhibited by Yersinia YopJ

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