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9783642719868

Somatic Diversification of Immune Responses

by ;
  • ISBN13:

    9783642719868

  • ISBN10:

    3642719864

  • Edition: Reprint
  • Format: Paperback
  • Copyright: 2011-12-10
  • Publisher: Springer Nature
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List Price: $139.99

Summary

This volume offers an overview of some important aspects of immune function. V(D)J hypermutation drives the somatic evolution of antigen-reactive B lymphocytes and is necessary for the generation of protective humoral immunity. The mechanism of this hypermutation remains enigmatic, although several seemingly mutually exclusive models have been proposed. Perhaps surprisingly, this volume demonstrates that there is no consensus on the major problems in the area of somatic diversification; the same experimental data has been interpreted in different ways by various authors. This lack of consensus reveals that the field of somatic diversification, from top to bottom, is an exciting area of immunology that stubbornly keeps its secrets to itself.

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