The Spectrum of Mineral and Bone Disorder in Chronic Kidney Disease

by Olgaard, Klaus; Silver, Justin; Salusky, Isidro B.

• ISBN13: 9780199559176
• ISBN10: 0199559171
• Edition: 2nd
• Format: Paperback
• Copyright: 2010-08-06
• Publisher: Oxford University Press

Summary

Despite significant improvement in the management of patients with chronic kidney disease, the morbidity and mortality remain high. However more is now understood about the hormonal influence on bone and vascular structures, and there have been major advances in the field of bone and mineral metabolism. This has lead to the development of new treatment strategies and agents. This new second edition reflects the most current thinking and understanding in this fascinating field, as presented by world basic and clinical experts.

Author Biography

Klaus Olgaard is Professor of Nephrology and Internal Medicine at the University of Copenhagen and at Department of Nephrology, Rigshospitalet, Copenhagen, Denmark. His scientific interests are basic and clinical research in nephrology-endocrinology and uremia, especially related to physiology and pathophysiology of calcium, phosphorus, parathyroid hormone (PTH), PTH related peptide, vitamin D, renal osteodystrophy, vascular calcifications and post-transplant bone disease. Professor Olgaard was the President for the ERA-EDTA Congress held in Copenhagen in 2002. He is Past President of several national nephrology and transplantation societies including the Danish Society of Nephrology. He is subject editor for Nephrology Dialysis Transplantation, and has been a member of several editorial boards. Professor Olgaard has authored more than 210 publications in peer-reviewed international journals and was editor of the K/DIGO guidelines, 2006 on Bone and Mineral Metabolism in CKD.
Justin Silver is Professor of Medicine at the Hebrew University Hadassah Medical School and Chief of the Nephrology and Hypertension Services at Hadassah Hospital in Jerusalem. He is Director of the Minerva Center for Calcium and Bone Metabolism at Hadassah Hospital. Together with his colleague Tally Naveh-Many Ph.D. He studies the molecular biology of the parathyroid and in particular the pathophysiology of the secondary hyperparathyroidism of chronic renal failure. In ongoing work in their laboratory they study how calcium and phosphate regulate PTH gene expression. Professor Silver has published more than 160 papers and reviews on this and related fields, including fifteen book chapters. Isidro B. Salusky is a Distinguished Professor of Pediatrics at the David Geffen School of Medicine at UCLA. He is the Director of UCLA General Clinical Research Center, Director of the Pediatric Dialysis Program and Associate Dean for Clinical Research. Dr Salusky and his colleagues have made substantial contributions to the understanding and treatment of the bone and mineral abnormalities associated with chronic kidney disease in children. They have characterized the spectrum of renal osteodystrophy in paediatric patients as well as the effects of therapy with different vitamin D sterols. One of the seminal contributions was identification of vascular calcifications in children and young adults treated with dialysis. More recently, his work is focused on the specific actions of fibroblast growth factor 23(FGF-23) on bone and in the pathogenesis of chronic kidney disease-mineral bone disorder (CKD-MBD).

Table of Contents

Definition and classification of renal osteodystrophy and chronic kidney disease-mineral bone disorder (CKD-MBD)

New aspects of normal bone biology

Osteocytes and mineral metabolism

Calcium-sensing receptors (CaSRs) in kidney, bone and vessels

Regulation of parathyroid hormone biosynthesis and gene expression

Abnormal parathyroid gland function in CKD

PTHrP physiology and pathophysiology, and the PTH/PTHrP receptor

Vitamin D metabolism and action in CKD

Growth factors and cytokines in renal bone disease

Bone histomorphometry in renal osteodystrophy

The spectrum of renal osteodystrophy and vascular calcifications in uremia

Imaging of the skeleton and the joints in CKD

Non-invasive assessment of vascular calcification and arterial stiffness

Osteopenia in uremia

Acidosis and renal bone disease

Dialysis-associated amyloidosis

Pathogenesis of vascular calcification: experimental studies

Clinical consequences of arterial calcifications and soft-tissue calcifications in Chronic Kidney Disease

Clinical management of vascular and soft tissue calcifications in Chronic Kidney Disease patients

The role of the skeleton in the pathogenesis of vascular calcification in the Chronic Kidney Disease-Mineral Bone Disorder

Klotho: bone, kidney, vascular calcifications, and the ageing process

Physiology and pathology of calcium and magnesium transport

Phosphatonins in health and disease

FGF-23 in renal failure

New vitamin D analogs for chronic kidney disease patients

Calcimimetics and calcilytics in the treatment of chronic kidney disease-mineral and bone disorder

Medical therapy in chronic kidney disease

Chronic kidney disease-mineral and bone disorder (CKD-MBD) in children

Bone disease in renal transplant recipients

Imaging and intervention of parathyroid hyperplasia

Surgical management of secondary hyperparathyroidism

Morbidity and mortality related to disturbances in mineral metabolism in CKD

Table of Contents provided by Publisher. All Rights Reserved.