Attempting to stop a bank robbery on a crowded New York street, the amazing Spider-Man finds himself blamed for the accidental shooting of an innocent bystander. The newspapers have a field day with the incident, which makes the web-slinger the perfect target for mayoral candidate Brian Timilty.
However, Timilty is secretly the pawn of Tyler Stewart, a wealthy businessman seeking to take over New York's crime syndicates. To ensure his success, Stewart executes a plan guaranteed to keep the wall-crawling super hero from interfering with his grand designs: he frames Spider-Man for a grisly murder!
Wanted by the police, forced into hiding, Spider-Man must find a way to clear his name without being shot on sight. And that's when Electro and the Rhino - two of his deadliest foes - arrive on the scene to complicate matters...