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9780521048149

Statistical Evaluation of Mutagenicity Test Data

by
  • ISBN13:

    9780521048149

  • ISBN10:

    0521048141

  • Edition: 1st
  • Format: Paperback
  • Copyright: 2008-03-31
  • Publisher: Cambridge University Press

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Summary

This rigorous and practical account of the interpretation of mutagenicity test data draws upon the expertise of toxicologists and statisticians. Chemicals, such as drugs, food additives and pesticides, all need careful screening to eliminate potentially mutagenic compounds. Although guidelines exist on the performance of these tests, advice on data evaluation is scarce; this volume provides the statistical background necessary for toxicologists to understand, design and interpret mutagenicity tests. In addition to the nine chapters dealing with the different tests employed, there is an introductory chapter on some of the statistical principles involved, a glossary of useful terms and an appendix providing vital information on the availability of computer software. A large team of contributors and editors working under the auspices of the United Kingdom Environmental Mutagen Society (UKEMS) have contributed a wealth of first-hand experience in compiling this immensely practical book of use to both research and industrial toxicologists.

Table of Contents

Steering group
Contributors
Preface
List of abbreviations
Statistics and genetic toxicology - setting the scene
Analysis of data from microbial colony assays
Mammalian cell gene mutation assays based upon colony formation
Statistical evaluation of bacterial/mammalian fluctuation tests
Analysis of data from in vitro cytogenetic assays
Statistical methods for sister chromatid exchange experiments
Statistical analysis of in vivo cytogenetic assays
Statistical methods for the dominant lethal assay
Statistical methods for the design and analysis of mutation experiments with the fruit fly Drosophila melanogaster
Appendices
Index
Table of Contents provided by Publisher. All Rights Reserved.

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