Statistical Mechanics, Protein Structure, and Protein Substrate Interactions

by Doniach, Sebastian

• ISBN13: 9780306447280
• ISBN10: 0306447282
• Format: Hardcover
• Copyright: 1994-09-01
• Publisher: Plenum Pub Corp

Table of Contents

Pathways and Mechanism of Protein Folding	p. 1
The Folding Pathway of Apomyoglobin	p. 7
Circular Dichroism Stopped-Flow Studies of Folding Intermediates	p. 19
Native-like Intermediates in Protein Folding	p. 31
A First-Order Phase Transition Between a Compact Denatured State and a Random Coil State in Staphylococcal Nuclease	p. 39
Studies on "Hyperstable" Proteins: Crystallins from the Eye-Lens and Enzymes from Thermophilic Bacteria	p. 49
Origins of Mutation Induced Stability Changes in Barnase: An Analysis Based on Free Energy Calculations	p. 63
Monte Carlo Simulation of Electrostatic Interactions in Biomolecules	p. 75
The Molecular Origin of the Large Entropies of Hydrophobic Hydration	p. 87
Statistical Mechanics of Secondary Structures in Proteins: Characterization of a Molten Globule-like State	p. 103
Hydrophobic Zippers: A Conformational Search Strategy for Proteins	p. 109
Theoretical Perspectives on In Vitro and In Vivo Protein Folding	p. 115
On the Configurations Accessible to Folded and to Denatured Proteins	p. 135
Experiences with Dihedral Angle Space Monte Carlo Search for Small Protein Structures	p. 147
Constrained Langevin Dynamics of Polypeptide Chains	p. 159
MOIL: A Molecular Dynamics Program with Emphasis on Conformational Searches and Reaction Path Calculations	p. 165
Flexibility in the Fc Region of Immunoglobulin G	p. 193
Computer-Supported Protein Structure Determination by NMR	p. 197
Enumeration with Constraints: A Possible Approach to Protein Structure Reconstruction from NMR Data	p. 209
A Decomposition of the nOe Intensity Matrix	p. 225
Structure and Dynamics of Membrane Proteins	p. 229
Steps Toward Predicting the Structure of Membrane Proteins	p. 239
Protein Fold Families and Structural Motifs	p. 253
Data Based Modeling of Proteins	p. 277
Applications of Knowledge Based Mean Fields in the Determination of Protein Structures	p. 297
A New Approach to Protein Folding Calculations	p. 317
Knowledge Based Potentials for Predicting the Three-Dimensional: Conformation of Proteins	p. 327
Protein-Protein Recognition: An Analysis by Docking Simulation	p. 331
Molecular Dynamics Simulation of an Antigen-Antibody Complex: Hydration Structure and Dissociation Dynamics	p. 339
Multiple Conformations of Cystatin, Mung Bean Inhibitor and Serpins	p. 351
Structure and tRNA [superscript Phe]-Binding Properties of the Zinc Finger Motifs of HIV-1 Nucleocapsid Protein	p. 369
Electrostatic Complementarity in Protein-Substrate Interactions and Ligand Design	p. 373
Molecular Engineering in the Preparation of Bioactive Peptides	p. 381
Author Index	p. 401
Subject Index	p. 403
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