Statistics Applied to Bioinformatics

by Van Helden, Jacques

• ISBN13: 9780199226757
• ISBN10: 019922675X
• Format: Hardcover
• Copyright: 2099-07-01
• Publisher: Oxford University Press

Summary

A text based on the author's Masters level course on statistics applied to bioinformatics aimed at graduate students from statistics, bioinformatics and biology. Filling a gap in the current literature, the text includes a rigorous and extensive background in biostatistics, along with detailed explanation of the key biological questions before focusing on the statistical analysis. Including exercises, numerous illustrations, extensive end of chapter summaries and examples of programming in R (a freely availabe statistical package), this is an ideal study text.

Table of Contents

Contents

Introduction

Statistics and bioinformatics

Scope and approach of the book

Acknowledgements

Supporting material

Warning

Bioinformatics and Biology

Sequence searchers in databases

Gene prediction

Detection of sequence motifs

Comparative genomics

Expression profiles

Networks of interaction

Sequence Analysis

Combinatorial analysis

Descriptive statistics

Elements of probabilities

Theoretical distributions of probabilities

Sampling and estimation

Statistical tests

Hidden Markov Models (HMM)

An information theory perspective

Transcriptome

Introduction to multivariate analysis

Correlation analysis

Regression analysis

Analysis of variance

Unsupervised classification (Clustering

Reduction of dimensionality and visualization

Supervised classification (discriminant analysis)

Genome Evolution

Biochemical Networks

Exercises

Annexes

Formula tables

Index

References

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